2023
DOI: 10.1101/2023.11.22.568119
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Impact of electrodes design and insertion methods to surrounding cortical tissues from high-density arrays

Ingrid N. McNamara,
Steven M. Wellman,
Lehong Li
et al.

Abstract: ObjectiveOver the past decade, neural electrodes have played a crucial role in bridging biological tissues with anthropomorphic devices. This study focuses on evaluating the optimal pitch, tip profile, and insertion speed for effectively implanting Paradromics’ high-density Fine Microwire Arrays (FμA) prototypes into the primary visual cortex (V1) of mice and rats, addressing the challenges associated with the “bed-of-nails” effect and tissue dimpling.ApproachTissue response was assessed by investigating the i… Show more

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