Impact of Elevated Cystatin C Level on Cardiovascular Disease Risk in Predominantly High Cardiovascular Risk Populations

Lee, Meng; Saver, Jeffrey L.; Huang, Wen‐Hung; Chow, Jessica; Chang, Kuo‐Hsuan; Ovbiagele, Bruce

doi:10.1161/circoutcomes.110.957696

Cited by 65 publications

(41 citation statements)

References 46 publications

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“…However, we did adjust for anemia in the multivariable analyses and showed in a cohort of 754 patients followed at a specialized HF clinic (in whom we had hemoglobin data) that renal insufficiency is an independent prognostic factor, even after adjusting for hemoglobin values. 7 In the same vein, we do not have data on other renal function metrics, such as albuminuria, 22 rate of change in eGFR, 28 or cystatin C levels, 21,29 which appear to be prognostically important in patients regardless of eGFR level; however, this mimics clinical practice in that the majority of patients with HF are managed without access to cystatin C levels. Finally, we acknowledge that there is variability between laboratories in measurement of SCr levels before the introduction of isotope-dilution mass spectrometry standardization in the mid-2000s; however, this variability was shown to predominantly introduce error at higher eGFR levels (ie, Ͼ60 mL/min), which were not the focus of the present study.…”

Section: Discussionmentioning

confidence: 96%

Renal Dysfunction in Patients With Heart Failure With Preserved Versus Reduced Ejection Fraction

McAlister

Ezekowitz²,

Tarantini³

et al. 2012

Circ: Heart Failure

173

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Section: Discussionmentioning

confidence: 96%

Renal Dysfunction in Patients With Heart Failure With Preserved Versus Reduced Ejection Fraction

McAlister

Ezekowitz²,

Tarantini³

et al. 2012

Circ: Heart Failure

173

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“…The Cochrane Collaboration Review Manager Software Package (RevMan 5) was used for the meta-analysis of observational studies. 7,11 Standard protocol approvals, registrations, and patient consents. Because this was an analysis based on data obtained from a search of publicly available/accessible published scientific literature, formal review by the institutional review board at our institution was not required.…”

Section: Data Extractionmentioning

confidence: 99%

Presence of baseline prehypertension and risk of incident stroke

Lee¹,

Saver²,

Chang³

et al. 2011

Neurology

101

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Objective: To qualitatively and quantitatively assess the association of prehypertension with incident stroke through a meta-analysis of prospective cohort studies. Methods:We searched Medline, Embase, the Cochrane Library, and bibliographies of retrieved articles. Prospective cohort studies were included if they reported multivariate-adjusted relative risks (RRs) and corresponding 95% confidence intervals (CI) of stroke with respect to baseline prehypertension. Results Conclusions:Prehypertension is associated with a higher risk of incident stroke. This risk is largely driven by higher values within the prehypertensive range and is especially relevant in nonelderly persons. Randomized trials to evaluate the efficacy of blood pressure reduction in persons with this designation are warranted. In recognition of the profound impact of elevated blood pressure on cardiovascular risk, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) proposed a new category of individuals within the range of normal blood pressure at risk for developing hypertension and its untoward sequela. 1This new designation, called prehypertension, comprises persons with systolic blood pressure between 120 and 139 mm Hg or diastolic blood pressure between 80 and 89 mm Hg.1 Since the JNC 7 proposal, epidemiologic studies have shown that the prevalence of prehypertension among adults in the general population is roughly 31% in the United States.2 However, the rationale and relevance of diagnosing prehypertension in otherwise healthy patients have recently been called into question.3 Indeed, even though stroke is the condition most highly correlated with blood pressure among various vascular disease entities, 4 the association of prehypertension with stroke risk in published studies has been inconsistent.Given its high prevalence and potential to identify persons at great stroke risk who may benefit from risk reduction strategies, we undertook a meta-analysis of prospective cohort studies to qualitatively and quantitatively assess the association of baseline prehypertension and risk of incident stroke.

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“…Oni su zaključili da se cistatin C može koristiti, osim kao parametar za procjenu bubrežne funkcije, i kao parametar za procjenu dijabetesne dislipidemije i kardiovaskularnog rizika kod oboljelih od DM tipa 2 sa slabom regulacijom glikemije [22]. Slične rezultate, koji potvrđuju povezanost cistatina C i faktora rizika za nastanak KVB kod oboljelih od DM pokazali su i drugi autori u svojim istraživanjima [8,[22][23][24][25].…”

Section: Diskusijaunclassified

Značaj cistatina C kao faktora rizika za kardiovaskularne bolesti kod oboljelih od tipa 2 diabetes mellitus-a

Vlastimir¹,

Risovic²,

Pejičićw³

2017

Biomedicinska istraž.

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Kratak sadržajUvod. Kardiovaskularne bolesti (KVB) su glavni uzrok smrti kod oboljelih od diabetes mellitus-a (DM). Danas se smatra da je tip 2 DM ekvivalent koronarne bolesti, te se preporučuje intenzivna kontrola svih faktora rizika za nastanak KVB kod oboljelih od DM. Cistatin C nije samo pouzdan parametar za procjenu jačine glomerulske filtracije (Glomerular Filtration Rate, GFR) nego može biti i koristan prediktor za utvrđivanje prisustva i predviđanje nastanka KVB. Cilj rada je bio da se procijeni bubrežna funkcija izračunavanjem GFR iz koncentracije cistatina C u serumu te da se ispita korelacija cistatina C i faktora rizika za KVB kod oboljelih od tipa 2 DM.Metode. Kod 70 ispitanika, dobi od 40-70 godina, podijeljenih u dvije grupe: 40 oboljelih od tipa 2 DM i kontrolnu grupu od 30 zdravih ispitanika, procjenjivana je bubrežna funkcija određivanjem koncentracije cistatina C u serumu, te njegova korelacija sa faktorima rizika za KVB: dislipidemijom, hipertenzijom, pušenjem, prisustvom KVB u porodičnoj anamnezi i albuminurijom.Rezultati. Analizom faktora rizika kod oboljelih od DM utvrđeno je da su vrijednosti HDL bile snižene kod bolesnika ženskog pola. Prosječne vrijednosti LDL i triglicerida bile su povišene, kao i albuminurija. Deset bolesnika sa DM bili su pušači, a kod 7 od ovih utvrđeno je prisustvo KVB u porodičnoj anamnezi. Vrijednosti cistatina C su pokazale statistički značajnu direktnu korelaciju sa vrijednostima albuminurije (r = 0,39, p < 0,05), sistolnim krvnim pritiskom (r = 0,33, p < 0,05) i vrijednostima triglicerida (r = 0,42, p < 0,05), a statistički značajnu obrnutu korelaciju sa vrijednostima HDL holesterola (r = -0,40, p < 0,05). Kod oboljelih od DM uočena je smanjena bubrežna funkcija, što predstavlja dodatni faktor rizika za nastanak KVB.Zaključak. U ovom istraživanju, cistatin C je pokazao značajnu korelaciju sa faktorima rizika za KVB kod oboljelih od tipa 2 DM.

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Impact of Elevated Cystatin C Level on Cardiovascular Disease Risk in Predominantly High Cardiovascular Risk Populations

Cited by 65 publications

References 46 publications

Renal Dysfunction in Patients With Heart Failure With Preserved Versus Reduced Ejection Fraction

Renal Dysfunction in Patients With Heart Failure With Preserved Versus Reduced Ejection Fraction

Presence of baseline prehypertension and risk of incident stroke

Značaj cistatina C kao faktora rizika za kardiovaskularne bolesti kod oboljelih od tipa 2 diabetes mellitus-a

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