Impact of elevated serum lipoprotein (a) concentrations on the risk of coronary heart disease in patients with type 2 diabetes mellitus

Okubo, Minoru; Amemiya-Kudo, Michiyo; Ebara, Tetsu; Mori, Yusaku

doi:10.1016/j.metabol.2008.01.020

Cited by 19 publications

(8 citation statements)

References 23 publications

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“…This discrepancy might reflect a more significant susceptibility of subsequent cardiovascular events for ACS patients than the general population. The cut-off value 15.2 mg/dl in our study is lower than most of those reported previously [15][16][17]. Racial differences may be an explanation.…”

contrasting

confidence: 80%

Association between Lipoprotein (a) level on admission and the incidence of subsequent cardiovascular events in patients with acute coronary syndrome

Zhou

Cui

Jin

et al. 2012

International Journal of Cardiology

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contrasting

confidence: 80%

Association between Lipoprotein (a) level on admission and the incidence of subsequent cardiovascular events in patients with acute coronary syndrome

Zhou

Cui

Jin

et al. 2012

International Journal of Cardiology

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“…High Lp(a) levels are strongly correlated with the severity of CAD [76, 83–89] as well as long-term adverse outcome, irrespective of the presence of traditional risk factors [90–97]. Lp(a) is a strong independent predictor of coronary artery calcification (CAC) and CAD in patients with diabetes [98–101]. The severity of the CAD is markedly increased when both diabetes and elevated Lp(a) levels are present.…”

Section: Resultsmentioning

confidence: 99%

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

Palaniappan

Garg

Enas³

et al. 2018

J Community Health

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South Asians (SAs) are at heightened risk for cardiovascular disease as compared to other ethnic groups, facing premature and more severe coronary artery disease, and decreased insulin sensitivity. This disease burden can only be partially explained by conventional risk factors, suggesting the need for a specific cardiovascular risk profile for SAs. Current research, as explored through a comprehensive literature review, suggests the existence of population specific genetic risk factors such as lipoprotein(a), as well as population specific gene modulating factors. This review catalogues the available research on cardiovascular disease and genetics, anthropometry, and pathophysiology, and cancer genetics among SAs, with a geographical focus on the U.S. A tailored risk profile will hinge upon population customized classification and treatment guidelines, informed by continued research.

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“…It has been reported as a predictor of deterioration of renal function [42], peripheral arterial disease [43], CVD [44] including CHD [45], and cardiovascular mortality [46] in patients with type 2 diabetes and a predictor of CVD [47] in patients with type 1 diabetes. It is of interest that the serum level of lipoprotein(a), which is known to be less affected by lifestyle or medication than other cardiovascular risk factors [48], was also a significant factor independent from lifestyle in our cohort.…”

Section: Discussionmentioning

confidence: 99%

Long-term lifestyle intervention lowers the incidence of stroke in Japanese patients with type 2 diabetes: a nationwide multicentre randomised controlled trial (the Japan Diabetes Complications Study)

et al. 2010

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Aims/hypothesisThe aim of the study was to clarify whether a therapeutic intervention focused on lifestyle modification affected the incidence of vascular complications in patients with established diabetes.MethodsA total of 2,033 eligible Japanese men and women aged 40–70 years with type 2 diabetes from 59 institutes were randomised to a conventional treatment group (CON), which continued to receive the usual care, and a lifestyle intervention group (INT), which received education on lifestyle modification regarding dietary habits, physical activities and adherence to treatment by telephone counselling and at each outpatient clinic visit, in addition to the usual care. Randomisation and open-label allocation were done by a central computer system. Primary analysis regarding measurements of control status and occurrence of macro- and microvascular complications was based on 1,304 participants followed for an 8 year period.ResultsAlthough status of control of most classic cardiovascular risk factors, including body weight, glycaemia, serum lipids and BP, did not differ between groups during the study period, the incidence of stroke in the INT group (5.48/1,000 patient-years) was significantly lower than in the CON group (9.52/1,000 patient-years) by Kaplan–Meier analysis (p = 0.02 by logrank test) and by multivariate Cox analysis (HR 0.62, 95% CI 0.39–0.98, p = 0.04). The incidence of CHD, retinopathy and nephropathy did not differ significantly between groups. Lipoprotein(a) was another significant independent risk factor for stroke.Conclusions/interpretationThese findings suggest that lifestyle modification had limited effects on most typical control variables, but did have a significant effect on stroke incidence in patients with established type 2 diabetes.Clinical Trial Registration: UMIN-CTR C000000222Funding: The Ministry of Health, Labour and Welfare, JapanElectronic supplementary materialThe online version of this article (doi:10.1007/s00125-009-1622-2) contains a list of members of the Japan Diabetes Complications Study Group, which is available to authorized users.

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Impact of elevated serum lipoprotein (a) concentrations on the risk of coronary heart disease in patients with type 2 diabetes mellitus

Cited by 19 publications

References 23 publications

Association between Lipoprotein (a) level on admission and the incidence of subsequent cardiovascular events in patients with acute coronary syndrome

Association between Lipoprotein (a) level on admission and the incidence of subsequent cardiovascular events in patients with acute coronary syndrome

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

Long-term lifestyle intervention lowers the incidence of stroke in Japanese patients with type 2 diabetes: a nationwide multicentre randomised controlled trial (the Japan Diabetes Complications Study)

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