Impact of endocrine disrupting chemicals on onset and development of female reproductive disorders and hormone-related cancer

Scsuková, Soňa; Rollerová, Eva; Mlynarčíková, Alžbeta Bujňáková

doi:10.1016/j.repbio.2016.09.001

Cited by 76 publications

(38 citation statements)

References 78 publications

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“…Initially, research into EDCs focused on their estrogenic property and their role in decreased fertility, decreased semen quality, and increased birth anomalies [ 7 ]. Soon, concerns expanded to more hormone-disrupters, including those that affect androgens or thyroid hormones [ 8 ], and other health issues, such as hormone-related cancers [ 9 ] and problems with neurodevelopment [ 10 ].…”

Section: A Brief History Of Research Into Edcsmentioning

confidence: 99%

Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues

Lee

2018

Endocrinol Metab

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Evidence has emerged that endocrine-disrupting chemicals (EDCs) can produce adverse effects, even at low doses that are assumed safe. However, systemic reviews and meta-analyses focusing on human studies, especially of EDCs with short half-lives, have demonstrated inconsistent results. Epidemiological studies have insuperable methodological limitations, including the unpredictable net effects of mixtures, non-monotonic dose-response relationships, the non-existence of unexposed groups, and the low reliability of exposure assessment. Thus, despite increases in EDC-linked diseases, traditional epidemiological studies based on individual measurements of EDCs in bio-specimens may fail to provide consistent results. The exposome has been suggested as a promising approach to address the uncertainties surrounding human studies, but it is never free from these methodological issues. Although exposure to EDCs during critical developmental periods is a major concern, continuous exposure to EDCs during non-critical periods is also harmful. Indeed, the evolutionary aspects of epigenetic programming triggered by EDCs during development should be considered because it is a key mechanism for developmental plasticity. Presently, living without EDCs is impossible due to their omnipresence. Importantly, there are lifestyles which can increase the excretion of EDCs or mitigate their harmful effects through the activation of mitohormesis or xenohormesis. Effectiveness of lifestyle interventions should be evaluated as practical ways against EDCs in the real world.

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Section: A Brief History Of Research Into Edcsmentioning

confidence: 99%

Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues

Lee

2018

Endocrinol Metab

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“…In estrogen-dependent cancers, E2 was found to increase the metastatic potential by inducing EMT, migration, and invasion of cancer cells via the ER-dependent pathway [ 21 , 30 , 31 ]. In this regard, EDCs having estrogenic activity are also implicated with cancer progression and metastasis of estrogen-dependent cancers [ 30 , 32 ]. As typical EDCs, bisphenol A, and nonylphenol were reported to enhance the EMT process and migration of ovarian cancer cells via the ER-dependent pathway [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

3,3′-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway

Kim

et al. 2018

IJMS

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Cyprodinil (CYP) is a pyrimidine amine fungicide that has been extensively used in agricultural areas. 3,3 -Diindolylmethane (DIM) is a derivative of the dietary phytoestrogen, indole-3-carbinol (I3C), which is derived from cruciferous vegetables and considered to be a cancer-preventive phytonutrient agent. In this study, the effects of CYP and DIM were examined on the cell viability, invasion, and metastasis of human endometrial cancer cells, Ishikawa, via epithelial mesenchymal transition (EMT). CYP increased the level of cell viability of Ishikawa cells compared to DMSO as a control, as did E2. Ishikawa cells lost cell-to-cell contact and obtained a spindle-shaped or fibroblast-like morphology in response to the application of E2 or CYP by the cell morphology assay. In the cell migration and invasion assay, CYP enhanced the ability of migration and invasion of Ishikawa cells, as did E2. E2 and CYP increased the expressions of N-cadherin and Snail proteins, while decreasing the expression of E-cadherin protein as EMT-related markers. In addition, E2 and CYP increased the protein expressions of cathepsin D and MMP-9, metastasis-related markers. Conversely, CYP-induced EMT, cell migration, and invasion were reversed by fulvestrant (ICI 182,780) as an estrogen receptor (ER) antagonist, indicating that CYP exerts estrogenic activity by mediating these processes via an ER-dependent pathway. Similar to ICI 182,780, DIM significantly suppressed E2 and CYP-induced proliferation, EMT, migration, and invasion of Ishikawa cancer cells. Overall, the present study revealed that DIM has an antiestrogenic chemopreventive effect to withdraw the cancer-enhancing effect of E2 and CYP, while CYP has the capacity to enhance the metastatic potential of estrogen-responsive endometrial cancer.

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“…The use of 17β-estradiol (E2), as a type of EDCs, could pose potential risks to the natural ecosystem and humans [ 3 ]. It has been reported that E2 can cause various damage and cancer to the human health system by changing the function of the endocranium even at low concentrations [ 4 ]. The negative effects of E2 on organisms included inhibiting the production of fish eggs and causing sexual reversal of males [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Stabilized Fe–Mn Binary Oxide Nanoparticles: Effective Adsorption of 17β-Estradiol and Influencing Factors

Qiu

Yin

Liu

et al. 2018

IJERPH

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Fe–Mn binary oxide nanoparticles (FMBON) were reported to be high performance as adsorbent for pollutants removal from aqueous solution. However, there are still limitations in practice application due to the FMBON tend to aggregate into the micro millimeter level. In order to avoid the agglomeration of nanoparticles, this work synthesized the stabilized Fe–Mn binary oxide nanoparticles (CMC-FMBON) by using water-soluble carboxymethyl celluloses (CMC) as the stabilizer. The characteristics of CMC-FMBON and FMBON were measured by using Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and Zeta potential. This work systematically investigated the adsorption capacity of CMC-FMBON for 17β-estradiol (E2) and the influences of external environmental factors on E2 removal. The results indicated that CMC-FMBON had much smaller particles, wider dispersion and larger surface area than the FMBON. CMC-FMBON showed better adsorption performance for E2 than FMBON with the maximum adsorption capacity of CMC-FMBON and FMBON were 124.10 and 98.14 mg/g at 298 K, respectively. The experimental data can be well fitted by the model of pseudo-second-order and Langmuir model. The E2 removal by CMC-FMBON was obviously dependent on pH with the maximum adsorption occurring when the pH was acidic. The removal capacity of CMC-FMBON increased when enhancing ionic strength in solution. Background electrolytes promoted slightly E2 adsorption process whereas the presence of humic acid inhibited the E2 removal. π-π interactions, hydrogen bonds, and oxidation might be responsible for E2 removal. This research suggested that the CMC-FMBON has been considered to be a cost-efficient adsorbent for removing E2 from water.

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Impact of endocrine disrupting chemicals on onset and development of female reproductive disorders and hormone-related cancer

Cited by 76 publications

References 78 publications

Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues

Evidence of the Possible Harm of Endocrine-Disrupting Chemicals in Humans: Ongoing Debates and Key Issues

3,3′-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway

Fabrication of Stabilized Fe–Mn Binary Oxide Nanoparticles: Effective Adsorption of 17β-Estradiol and Influencing Factors

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