Impact of endocrine disrupting compounds in sewage impacted coastal area on seabream

Al-Jandal, Noura; Saeed, Talat; Azad, I.S.; Al-Subiai, Sherain N.; Al-Zekri, W.; Hussain, Sumaiah; Al-Hasan, E.

doi:10.1016/j.ecoenv.2017.12.035

Cited by 16 publications

(15 citation statements)

References 47 publications

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“…However, whether DEX alleviates apoptosis induced by acute stress in tubular cells or glomerular cells is unclear. Immunohistochemistry permits localization and quantification of antigens in tissue by specific antibodies [ 55 ]. The final common pathway of different apoptosis cascade reactions is activation of caspase 3 expression.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine Ameliorates Acute Stress‐Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway

Chen

Feng

et al. 2018

Oxidative Medicine and Cellular Longevity

106

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Acute stress induces tissue damage through excessive oxidative stress. Dexmedetomidine (DEX) reportedly has an antioxidant effect. However, protective roles and related potential molecular mechanisms of DEX against kidney injury induced by acute stress are unknown. Herein, rats were forced to swim 15 min followed by restraint stress for 3 h with/without DEX (30 μg/kg). Successful model establishment was validated by an open-field test. Assessment of renal function (creatinine, urea nitrogen), histopathology, oxidative stress (malondialdehyde, glutathione, and superoxide dismutase), and apoptosis (transferase-mediated dUTP nick end labeling) was performed. Localization of apoptosis was determined by immunohistochemistry of cleaved caspase 3 protein. In addition, key proteins of the death receptor-mediated pathway, mitochondrial pathway, endoplasmic reticulum stress (ERS) pathway, and ROS/JNK signaling pathway were measured by Western blot. We found that DEX significantly improved renal dysfunction, ameliorated kidney injury, reduced oxidative stress, and alleviated apoptosis. DEX also inhibited the release of norepinephrine (NE), decreased the production of reactive oxygen species (ROS), and inhibited JNK phosphorylation. Additionally, DEX downregulated the expression of Bax, cytochrome C, cleaved caspase 9, and cleaved caspase 3 proteins in mitochondria-dependent pathways. In summary, DEX protects against acute stress-induced kidney injury in rats by reducing oxidative stress and apoptosis via inhibition of the ROS/JNK pathway.

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Section: Discussionmentioning

confidence: 99%

Dexmedetomidine Ameliorates Acute Stress‐Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway

Chen

Feng

et al. 2018

Oxidative Medicine and Cellular Longevity

106

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“…Different treatment processes had different removal effects, and DBP was shown to tend to accumulate in the sludge, exceeding acceptable levels for a safe aquatic environment (Salaudeen et al, 2018). Noura (Al-Jandal et al, 2018) revealed significant levels of phthalates in seawater (2.1-4.6 µg/L) and sediment (2.1-15.7 mg/kg dry wt) samples. They deduced that the phthalates were from wastewater treatment plants due to detections in outflow samples.…”

Section: Introductionmentioning

confidence: 99%

Photodegradation Pathways of Typical Phthalic Acid Esters Under UV, UV/TiO2, and UV-Vis/Bi2WO6 Systems

Wang

Zeng

et al. 2019

Front. Chem.

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Photolysis and photocatalysis of typical phthalic acid esters (dimethyl phthalate, DMP; diethyl phthalate, DEP; dibutyl phthalate, DBP) were carried out in UV, UV/TiO 2 , and UV-Vis/Bi 2 WO 6 systems. All of the selected phthalic acid esters and their decomposition byproducts were subjected to qualitative and quantitative analysis through HPLC and GC-MS. The results of 300 min of photolysis and photodegradation reaction were that each system demonstrated different abilities to remove DMP, DEP, and DBP. The UV/TiO 2 system showed the strongest degradation ability on selected PAEs, with removal efficiencies of up to 93.03, 92.64, and 92.50% for DMP, DEP, and DBP in 90 min, respectively. UV-Vis/Bi 2 WO 6 had almost no ability to remove DMP and DEP. However, all of the systems had strong ability to degrade DBP. On the other hand, the different systems resulted in various byproducts and PAE degradation pathways. The UV system mainly attacked the carbon branch and produced o-hydroxybenzoates. No ring-opening byproducts were detected in the UV system. In the photocatalytic process, the hydroxyl radicals produced not only attacked the carbon branch but also the benzene ring. Therefore, hydroxylated compounds and ring-opening byproducts were detected by GC-MS in both the UV/TiO 2 and UV-Vis/Bi 2 WO 6 photocatalytic systems. However, there were fewer products due to direct hole oxidation in the UV-Vis/Bi 2 WO 6 system compared with the UV/TiO 2 system, which mainly reacted with the pollutants via hydroxyl radicals.

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“…Similar findings were reported earlier by Al-Ghais and Ali (1999), who reported that S. canaliculatus was a more sensitive indicator species for detecting the presence of organotins when compared to Sparus sarba. The threat posed by chemical contaminants with endocrine disrupting potential is an area of growing concern in the Gulf (Smith et al, 2015;Saeed et al, 2017;Al-Jandal et al, 2018). Endocrine distrusting compounds (EDCs) can find their way into the Gulf's marine environment through both industrial and domestic effluents and pose a risk to exposed biota through the disruption of the normal functioning of hormonal systems, leading to behavioral disorders and reproductive cycle disturbances (Matthiessen et al, 2018).…”

Section: Cellular Biochemical and Histological Biomarkersmentioning

confidence: 99%

“…These include eutrophication (Devlin et al, 2019), inputs of domestic sewage (Lyons et al, 2015b;Saeed et al, 2015), discharges of industrial waste, including brine from the vast network of desalination plants (Naser, 2013;Al-Sarawi et al, 2015) and the resuspension of sediment and habitat loss, due to the significant amounts of coastal construction that has taken place in recent years (Sheppard et al, 2012;Sheppard, 2016). A number of studies have now described hot spots of contamination, particularly by petroleum hydrocarbons and metals in sediments and waters near industrial sites (de Mora et al, 2004;Naser, 2014;Soliman et al, 2014;Al-Sarawi et al, 2015), along with a small but growing body of evidence documenting the presence of so called 'emerging contaminants', including those with endocrine disrupting (Smith et al, 2015;Saeed et al, 2017;Al-Jandal et al, 2018) and antimicrobial activity (Al-Sarawi et al, 2018;Le Quesne et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The biological effects of chemical contaminants in the Arabian/Persian Gulf: A review

Khatir

Leitão

Lyons

2020

Regional Studies in Marine Science

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The Arabian Gulf is a shallow sea naturally exposed to extreme conditions of temperature and salinity due to its location, semi-enclosed nature, bathymetry and restricted circulation. Compared to open marine systems, the added stress imposed by pollutants is likely to have additional adverse consequences. Maintaining good marine environmental quality is crucial for several socioeconomic reasons, one of the most important being that the region relies heavily on seawater as a source of freshwater through desalination. While regionally based marine monitoring programs employing chemical endpoints have been widely deployed, few have evaluated the potential biological effects of those contaminants detected. However, it is now widely recognized that an integrated approach using both chemical measurements and appropriate biological endpoints in key sentinel species is essential to the design and implementation of marine environmental programs. Here we present an exhaustive review of the studies published so far in the Gulf on the biological effects of chemical contaminants using different biological endpoints and suggest potential areas requiring additional research.

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Impact of endocrine disrupting compounds in sewage impacted coastal area on seabream

Cited by 16 publications

References 47 publications

Dexmedetomidine Ameliorates Acute Stress‐Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway

Dexmedetomidine Ameliorates Acute Stress‐Induced Kidney Injury by Attenuating Oxidative Stress and Apoptosis through Inhibition of the ROS/JNK Signaling Pathway

Photodegradation Pathways of Typical Phthalic Acid Esters Under UV, UV/TiO2, and UV-Vis/Bi2WO6 Systems

The biological effects of chemical contaminants in the Arabian/Persian Gulf: A review

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