Impact of endocrine-disrupting compounds (EDCs) on female reproductive health

Fowler, Paul A.; Bellingham, Michelle; Sinclair, Kevin D.; Evans, Neil P.; Pocar, Paola; Fischer, Bernd; Schaedlich, Kristina; Schmidt, J.; Amezaga, Maria R.; Bhattacharya, Siladitya; Rhind, S. M.; O’Shaughnessy, Peter J.

doi:10.1016/j.mce.2011.10.021

Cited by 204 publications

(104 citation statements)

References 117 publications

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“…These results are similar to [25] observations that acute sub-lethal concentrations of atrazine caused a significant increase in ALT and AST of C. carpio. The AST is a mitochondrial enzyme found in the blood, heart, kidney and skeletal muscle [26]. The induction of ROS due to mitochondrial damage following atrazine intoxication may explain the elevation of AST in the blood of C. gariepinus.…”

Section: Discussionmentioning

confidence: 99%

Atrazine-Mediated Oxidative Stress Responses and Lipid Peroxidation in the Tissues of Clarias gariepinus

Owolabi

Omotosho

2017

IJT

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Section: Discussionmentioning

confidence: 99%

Atrazine-Mediated Oxidative Stress Responses and Lipid Peroxidation in the Tissues of Clarias gariepinus

Owolabi

Omotosho

2017

IJT

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“…Endocrine and metabolic circuits characterize embryo-maternal interactions in these pregnancy stages, and confounders have been described, with most attention recently being paid to endocrine disrupters (cf. Fowler et al 2012) and prevalent metabolic diseases such as diabetes mellitus and adiposity. Adipokines, a subset of cytokines derived from adipose tissue, affect metabolism and obesity particularly, as also fertility in women (Mitchell et al 2005).…”

Section: Feto-placental Interactions and Placental Function And Imagingmentioning

confidence: 99%

Rabbit as a reproductive model for human health

Fischer¹,

Chavatte‐Palmer²,

Viebahn³

et al. 2012

Reproduction

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149

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The renaissance of the laboratory rabbit as a reproductive model for human health is closely related to the growing evidence of periconceptional metabolic programming and its determining effects on offspring and adult health. Advantages of rabbit reproduction are the exact timing of fertilization and pregnancy stages, high cell numbers and yield in blastocysts, relatively late implantation at a time when gastrulation is already proceeding, detailed morphologic and molecular knowledge on gastrulation stages, and a hemochorial placenta structured similarly to the human placenta. To understand, for example, the mechanisms of periconceptional programming and its effects on metabolic health in adulthood, these advantages help to elucidate even subtle changes in metabolism and development during the pre-and peri-implantation period and during gastrulation in individual embryos. Gastrulation represents a central turning point in ontogenesis in which a limited number of cells program the development of the three germ layers and, hence, the embryo proper. Newly developed transgenic and molecular tools offer promising chances for further scientific progress to be attained with this reproductive model species.

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“…Since then, a plethora of studies has been conducted both in humans and in a variety of animal model species, including farm animals, that support these initial observations, and these have been the subject of extensive review and meta-analysis in recent years (e.g. McMillen and Robinson 2005;Gluckman et al 2008;Fowler et al 2012;Thayer et al 2012;Langley-Evans 2013;Steegers-Theunissen et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

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Abstract. The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

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Impact of endocrine-disrupting compounds (EDCs) on female reproductive health

Cited by 204 publications

References 117 publications

Atrazine-Mediated Oxidative Stress Responses and Lipid Peroxidation in the Tissues of Clarias gariepinus

Atrazine-Mediated Oxidative Stress Responses and Lipid Peroxidation in the Tissues of Clarias gariepinus

Rabbit as a reproductive model for human health

Epigenetics and developmental programming of welfare and production traits in farm animals

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