2021
DOI: 10.1111/jdi.13479
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Impact of endogenous insulin secretion on the improvement of glucose variability in Japanese patients with type 2 diabetes treated with canagliflozin plus teneligliptin

Abstract: Aims/Introduction: To identify the effect of combination therapy with a dipeptidyl peptidase-4 inhibitor and a sodium-glucose cotransporter 2 inhibitor compared with switching from a dipeptidyl peptidase-4 inhibitor to a sodium-glucose cotransporter 2 inhibitor on improving the glucose variability in patients with or without impaired endogenous insulin secretion. Materials and Methods: A secondary analysis regarding the relationship between endogenous insulin secretion and the change in mean amplitude of glyce… Show more

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“…Although glycated hemoglobin (HbA1c) is frequently used to evaluate glycemic control in clinical practice, it is now thought that stable glycemic control, with minimal GV, is also required for the prevention of diabetic cardiovascular complications in patients with type 2 diabetes (T2DM) [2]. Therefore, the importance of therapies associated with low GV has been advocated, and a number of studies have made use of continuous glucose monitoring (CGM) devices to assess this [3][4][5].…”
Section: Introductionmentioning
confidence: 99%
“…Although glycated hemoglobin (HbA1c) is frequently used to evaluate glycemic control in clinical practice, it is now thought that stable glycemic control, with minimal GV, is also required for the prevention of diabetic cardiovascular complications in patients with type 2 diabetes (T2DM) [2]. Therefore, the importance of therapies associated with low GV has been advocated, and a number of studies have made use of continuous glucose monitoring (CGM) devices to assess this [3][4][5].…”
Section: Introductionmentioning
confidence: 99%