Impact of endometriosis on the ovarian follicles

Hypoxia and the endometrium: An indispensable role for HIF-1α as therapeutic strategies

“…Notably, considering the diversity of implantation sites for ectopic endometrial lesions, the activation of HIF-1α signaling pathways in various tissues can exert pathological effects through different mechanisms. Ovarian endometriosis is the most common subtype of endometriosis, leading to a decrease in the quality and quantity of oocytes and infertility [ 68 ]. Previous studies identified the upregulation of HIF-1α and its downstream proangiogenetic factors in ovarian endometriotic tissues, especially the outer capsule of ovarian endometriosis [ 69 ].…”