2018
DOI: 10.1007/s12630-018-1060-z
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Impact of ENIGMA trials on nitrous oxide: a survey of Canadian anesthesiologists and residents

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Cited by 6 publications
(6 citation statements)
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“…This finding supported the safety profile of N 2 O [131]. Nevertheless, the use of N 2 O in clinical practice has dramatically declined, mainly due to PONV risk and environmental considerations [132].…”
Section: Non-cardiac Surgerysupporting
confidence: 63%
“…This finding supported the safety profile of N 2 O [131]. Nevertheless, the use of N 2 O in clinical practice has dramatically declined, mainly due to PONV risk and environmental considerations [132].…”
Section: Non-cardiac Surgerysupporting
confidence: 63%
“…Thus, high homocysteine levels may facilitate peripheral inflammation induced by surgery trauma and accelerate the development of cognitive decline in an already susceptible brain. Interestingly, the ENIGMA trial showed that postoperative plasma homocysteine concentrations were increased in patients receiving nitrous oxide, which may etiologically contribute to the link between nitrous oxide and myocardial infarction (Jain et al 2018 , Leslie et al 2011 ). Another study also confirmed nitrous oxide for longer than 3 h is associated with increasing homocysteine levels in patients (Hakimoglu et al 2013 ).…”
Section: Discussionmentioning
confidence: 99%
“…11 A recent Canadian study noted that ENIGMA had reduced nitrous oxide use by anaesthesiologists, but that ENIGMA-II had not led to a recovery in usage. 12 The use of NMBAs has remained stable since the 2013 survey, 1 with almost half of patients undergoing GA receiving NMBAs, and with stable distribution across age groups. Regarding the choice of neuromuscular blocking agent, the use of succinylcholine appears to have declined, both overall and during Caesarean section.…”
Section: Discussionmentioning
confidence: 99%