Impact of enteral nutrition on nitrogen balance in patients of trauma

Jivnani, Sabita; Iyer, Sandhya; Umakumar, Kabeer; Ma, Gore

doi:10.4103/0974-2700.62101

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…The estimation of the nitrogen losses represented the main limitation. In the present study, we considered a constant of 4 g/day, accounting for non-urinary losses [13]. However, it is difficult to establish such a measure, since no easy measurements are available [30].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial

et al. 2019

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Nitrogen balance (NB) is considered a good marker of adequate protein intake and it has been suggested to be a good predictor of patients’ health outcomes. However, in literature, there is a lack of large randomized trials examining NB-guided protein intake in patients in intensive care units (ICUs). A randomized controlled trial enrolling patients admitted to ICU was done to compare changes in NB. Participants were randomized to a standard or protein-fortified diet (protein intake of 1.8 g/kg/day according to the guidelines of the Society of Critical Care Medicine and the American Society for Parenteral and Enteral Nutrition). The primary endpoint was represented by the NB on Day 1, 3, and study exit. Forty patients were enrolled in the study (19 in the protein-fortified group). The longitudinal analysis showed that, on Day 3, patients randomized to the protein-fortified diet were more likely (p < 0.001) to present better NB (at 3 days, patients in the protein-fortified diet were estimated to have a nitrate value of 5.22 g more than patients in the standard diet, 95% CI 3.86–6.58). The protein-fortified diet was found to be significantly and directly associated with changes in NB in critically ill patients admitted to ICU.

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Section: Discussionmentioning

confidence: 99%

“…Blood analyses were carried out using spectrophotometry. NB was calculated daily using the standard formula described by Jivnani et al [13]. Subjects remained in the study until mechanically ventilated.…”

Section: Methodsmentioning

confidence: 99%

Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial

et al. 2019

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The Role of Chondroprotectants, Nutraceuticals, and Nutrition in Rehabilitation

Raditic¹,

Bartges²

2014

Canine Rehabilitation and Physical Therapy

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Moderate glucose control results in less negative nitrogen balances in medical intensive care unit patients: a randomized, controlled study

et al. 2012

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IntroductionHyperglycemia and protein loss are common in critically ill patients. Insulin can be used to lower blood glucose and inhibit proteolysis. The impact of moderate insulin therapy on protein metabolism in critically ill patients has not been evaluated. We compared urinary nitrogen excretion, nitrogen balance, serum albumin concentrations, prealbumin concentrations, and clinical outcomes between patients receiving moderate insulin therapy (MIT) and conventional insulin therapy (CIT) in a medical ICU.MethodsPatients were randomly divided into groups and treated with MIT (glucose target 120 to 140 mg/dl) or CIT (glucose target 180 to 200 mg/dl). Calories and protein intake were recorded each day. On days 3, 7 and 14, the 24-hour urinary nitrogen excretion, nitrogen balance, and serum albumin and prealbumin concentrations were measured. Clinical outcomes data were collected.ResultsA total of 112 medical ICU patients were included, with 55 patients randomized to the MIT group and 57 patients randomized to the CIT group. Patients treated with MIT showed a trend towards increased nitrogen balance (P = 0.070), significantly lower urinary nitrogen excretion (P = 0.027), and higher serum albumin (P = 0.047) and prealbumin (P = 0.001) concentrations than patients treated with CIT. The differences between the two groups were most significant on day 3, when all factors showed significant differences (P < 0.05).ConclusionsModerate glucose control results in less negative nitrogen balances in medical ICU patients. Differences are more significant in the early stages compared with the late stages of critical illness.Trial registrationClinicalTrial.Gov NCT 01227148

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Impact of enteral nutrition on nitrogen balance in patients of trauma

Cited by 4 publications

References 12 publications

Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial

Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial

The Role of Chondroprotectants, Nutraceuticals, and Nutrition in Rehabilitation

Moderate glucose control results in less negative nitrogen balances in medical intensive care unit patients: a randomized, controlled study

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