Impact of Environmental and Familial Factors in a Cohort of Pediatric Patients With Inflammatory Bowel Disease

Strisciuglio, Caterina; Giugliano, Francesca Paola; Martinelli, Massimo; Cenni, Sabrina; Greco, Luigi; Staiano, Annamaria; Miele, Erasmo

doi:10.1097/mpg.0000000000001297

Cited by 59 publications

(45 citation statements)

References 39 publications

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“…The mechanisms of how MUFA might be beneficial in colitis are unknown, although adherence to the Mediterranean diet pattern has been shown to beneficially affect the gut microbiome and gut metabolites (metabolome) [35]. A recent case-control study ( n = 264 IBD subjects and 203 controls) found that low adherence to the Mediterranean diet pattern was a significant risk factor in the development of pediatric UC (OR: 2.3; 1.2–4.5) [36]. An intervention study examining the impact of the Mediterranean diet pattern in CD ( n = 8) demonstrated a trend for reduction in inflammatory biomarkers ( p = 0.39) and a tendency for “normalization” of the gut microbiota [37].…”

Section: Diet Interventions and Ibdmentioning

confidence: 99%

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Haskey

Gibson

2017

Nutrients

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Diet has been speculated to be a factor in the pathogenesis of inflammatory bowel disease and may be an important factor in managing disease symptoms. Patients manipulate their diet in attempt to control symptoms, often leading to the adoption of inappropriately restrictive diets, which places them at risk for nutritional complications. Health professionals struggle to provide evidence-based nutrition guidance to patients due to an overall lack of uniformity or clarity amongst research studies. Well-designed diet studies are urgently needed to create an enhanced understanding of the role diet plays in the management of inflammatory bowel disease. The aim of this review is to summarize the current data available on dietary management of inflammatory bowel disease and to demonstrate that dietary modulation may be an important consideration in managing disease. By addressing the relevance of diet in inflammatory bowel disease, health professionals are able to better support patients and collaborate with dietitians to improve nutrition therapy.

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Section: Diet Interventions and Ibdmentioning

confidence: 99%

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Haskey

Gibson

2017

Nutrients

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“…A protective effect was observed in a diet enriched in vegetables, fruits, olive oil, fish, grains, and nuts in both genders among pediatric CD patients . Interestingly, Mediterranean diet could be one of anti‐inflammatory dietary patterns to meet the abovementioned demands and is recommended in our center, although limited studies supported this assumption in both UC and CD patients …”

Section: Diet In the Pathogenesis Of Ibdmentioning

confidence: 84%

“…68 Interestingly, Mediterranean diet could be one of anti-inflammatory dietary patterns to meet the abovementioned demands and is recommended in our center, although limited studies supported this assumption in both UC and CD patients. 70,71 3 | CLINICAL IMPLEMENTATION OF DIETARY INTERVENTIONS…”

Section: Dietary Patternmentioning

confidence: 99%

The role of dietary factors in inflammatory bowel diseases: New perspectives

Zhou

Yan

2018

J of Digest Diseases

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The current review aimed to elucidate the role of diet in every stage of inflammatory bowel diseases, from aspects of prevention, treatment and rehabilitation. Western diet, characterized by overconsumption of refined sugar and saturated fat and low consumption of dietary fiber, may partly be blamed for its pathogenesis. Some immune‐modulated nutrients (fibers, monounsaturated fatty acids, n‐3 polyunsaturated fatty acids and vitamin D) exert their potential beneficial effects on gut microbiota and immune function, resulting in clinical remission and/or preventing relapse. However, data is limited to conclude optimal micronutrient levels and therapeutic implications. Further, diet itself is complex; therefore, it is reasonable to evaluate diet as a whole rather than a single type of food. Some specific dietary patterns are generated for the management of inflammatory bowel diseases with controversial results. Only exclusive enteral nutrition has been widely recommended for pediatric patients with non‐stricturing active Crohn's disease. Self‐monitoring, avoidance of certain types of foods, limited intake of alcohol and smoking, supplementation of minerals and vitamins if deficiency is confirmed, and adherence to the diet enriched in vegetables and fruits and low in animal food and un‐digested fiber during flares are the most common dietary recommendation. Further clinical trials with a high evidence rank are warranted.

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“…Accordingly, IBD has been reported in 21%-62% of children with lower GI bleeding in other studies (20)(21)(22)(23). Risk factors associated with IBD in children have been socioeconomic factors such as parents' educations and occupations, as well as nutritional factors including early (<6 month of age) gluten exposure (6). Life style is supposed to affect the risk of IBD development as IBD has been frequently associated with western culture (24).…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of IBD in children is multifactorial. A history of IBD in siblings has been known as a traditional risk factor (6). There is a shortage of large population studies in pediatric IBD, and most available data on this come from adult onset IBD.…”

Section: Introductionmentioning

confidence: 99%

A survey on rectal bleeding in children, a report from Iran

2018

Turk J Med Sci

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Background/aim: Studies on the epidemiology of rectal bleeding in children are limited in Iran. Our aim was to assess etiologies of rectal bleeding in children in Iran. Materials and methods:We enrolled 730 children with rectal bleeding. All the patients underwent colonoscopy, and 457 were further evaluated with histopathology.Results: According to colonoscopy and histopathology, respectively, inflammatory bowel disease (IBD) (29.4%, 15.8%), nodular hyperplasia (NH) (24.9%, 10%), and juvenile polyposis (JP) (12.6%, 9.9%) were the most common causes of rectal bleeding. Other conditions were solitary rectal ulcer (5.3%), chronic colitis (4.6%), allergic colitis (3.3%), focal colitis (1.3%), and infectious colitis (1.1%). In colonoscopy, there were no significant differences in the distribution of pathologies regarding sex, while the youngest and oldest mean ages were found for patients with NH (4.6 ± 3.9 years, P < 0.0001) and those with normal appearance (8.1 ± 4.4 years, P < 0.0001) respectively. Based on histopathologic reports, the youngest patients were diagnosed with infectious colitis (4.6 ± 2.8 years), while patients with chronic colitis were the oldest (9.2 ± 4.6 years, P = 0.003). Conclusion:JP, NH, and IBD constituted the most common etiologies of rectal bleeding in our patients. It is recommended to perform a complete diagnostic approach to accurately assess rectal bleeding in children.

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Impact of Environmental and Familial Factors in a Cohort of Pediatric Patients With Inflammatory Bowel Disease

Abstract: Our study confirms that environmental factors are closely linked to IBD onset and may partly explain IBD rise in developed countries.

Cited by 59 publications

References 39 publications

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

The role of dietary factors in inflammatory bowel diseases: New perspectives

A survey on rectal bleeding in children, a report from Iran

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