Impact of environmental factors on human semen quality and male fertility: a narrative review

Kumar, Nand; Singh, Amit Kant

doi:10.1186/s12302-021-00585-w

Cited by 84 publications

(40 citation statements)

References 137 publications

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“…Employees exposed to high heat were at risk of developing physiological changes (increased heart rate, respiratory rate, core body temperature, and blood pressure), which can be explained by sweating resulting in dehydration [13]. Furthermore, male infertility among workers were reported to be associated with heat exposure [14].…”

Section: Introductionmentioning

confidence: 99%

Hematological parameters in a population of male bakers exposed to high heat work environment

Al-Otaibi

2022

PLoS ONE

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Objectives The aim of this study was to determine the hematological changes associated with heat exposure in a population of bakers. Materials and methods Personal information was collected using a questionnaire, and a venous blood sample was drawn at the end of a work shift from the bakers and from a control group. The average wet-bulb globe temperature (WBGT) index was measured in the workplaces of both the bakers and the controls. Results This cross-sectional study involved 137 bakers working in 20 bakeries and 107 controls who were comparable in terms of likely confounding factors. Hemoglobin and platelet values were abnormal among the bakers and statistically significantly different to the control group (P = 0.026, and P = 0.016 respectively). The average WBGT index in the bakeries was 37.4°C, while the average WBGT in the workplaces of the controls was 25.5°C, (P<0.0001). Conclusions The changes in the bakers’ hematological parameters were found to be associated with exposure to high environmental heat at bakeries, as measured by the WBGT index. Preventive measures should be introduced to reduce the adverse effect of heat exposure among bakers and directed toward the worker–equipment–environment triad.

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Section: Introductionmentioning

confidence: 99%

Hematological parameters in a population of male bakers exposed to high heat work environment

Al-Otaibi

2022

PLoS ONE

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“…Pesticides that have been linked to spermatogenesis defects, resulting in lower sperm counts, sperm mobility, and a rise in the frequency of morphologically abnormal sperms, Leydig cell dysfunction, and disrupted endocrine function during hormonal regulation processes, all of which led to male infertility (Bretveld et al, 2007; Kumar & Singh, 2022; Roeleveld & Bretveld, 2008). This study investigated the reproductive toxicity mechanisms of LF, a benzoylurea insecticide belonging to the non‐systemic insecticide IGRs class.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of avocado oil against lufenuron induced testicular damage and infertility in male rats

El‐Rahman

Omar

2022

Andrologia

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Lufenuron is a benzoylurea pesticide that causes significant histological and histochemical damage in mammals. Avocado is a common food in the human diet that contains antioxidant and antitumor properties. In male rats, avocado oil's protection against lufenuron-induced reproductive deterioration, oxidative stress, and DNA damages was investigated. Twenty-eight mature male rats were selected and distributed into four groups: Group 1, control group were administered distilled water orally; Group 2 received 4 ml/kg avocado; Group 3 was given lufenuron (1.6 mg/kg), and Group 4 was given avocado oil/lufenuron. The findings show that lufenuron treatment reduces reproductive hormone levels, sperm count, motility, viability and causes negative histopathological changes in testicular tissue, such as decreased epithelial height and increased luminal diameter degenerated spermatogenesis. Furthermore, lufenuron reduced the content of antioxidant enzymes while increasing the level of malondialdehyde, nitric oxide and corresponding DNA damage. Results showed that lufenuron is associated with testicular function impairment, which leads to infertility. Treatment with avocado oil improved reproductive hormone secretions, enzymatic activity, histological and DNA damage parameters in testis tissues, reducing the negative effects of lufenuron, proving that it may have a therapeutic role against lufenuron-mediated testicular toxicity.

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“…One key reason for the increase in male infertility is deteriorating semen quality [68]. Herein, the marked decline in sperm count, motility, and viability with a significant increase in morphological aberrations in the low or high Fe2O3-NPs-exposed rats reflected a pronounced deterioration of sperm quality.…”

Section: Discussionmentioning

confidence: 91%

Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats

Ahmed

Hussein

Saber

et al. 2022

IJERPH

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The nano-sized iron oxide (Fe2O3-NPs) is one of the most used engineered nanomaterials worldwide. This study investigated the efficacy of natural polyphenol resveratrol (RSV) (20 mg/kg b.wt, orally once daily) to alleviate the impaired sperm quality and testicular injury resulting from Fe2O3-NPs exposure (3.5 or 7 mg/kg b.wt, intraperitoneally once a week) for eight weeks. Spermiograms, sexual hormonal levels, oxidative stress indicators, and lipid peroxidation biomarker were assessed. Moreover, the steroidogenesis-related genes mRNA expressions were evaluated. The results showed that RSV substantially rescued Fe2O3-NPs-mediated sperm defects. Additionally, the Fe2O3-NPs-induced depressing effects on sperm motility and viability were markedly counteracted by RSV. Moreover, RSV significantly restored Fe2O3-NPs-induced depletion of testosterone, follicle-stimulated hormone, luteinizing hormone, and testicular antioxidant enzymes but reduced malondialdehyde content. Furthermore, the Fe2O3-NPs-induced downregulation of steroidogenesis-related genes (3 β-HSD, 17 β-HSD, and Nr5A1) was significantly counteracted in the testicular tissue of RSV-treated rats. These findings concluded that RSV could limit the Fe2O3-NPs-induced reduced sperm quality and testicular injury most likely via their antioxidant activity and steroidogenesis-related gene expression modulation.

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Impact of environmental factors on human semen quality and male fertility: a narrative review

Cited by 84 publications

References 137 publications

Hematological parameters in a population of male bakers exposed to high heat work environment

Hematological parameters in a population of male bakers exposed to high heat work environment

Ameliorative effect of avocado oil against lufenuron induced testicular damage and infertility in male rats

Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats

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