Impact of epidermal desquamation on tissue stores of iron

Milstone, Leonard M.; Hu, Ronghua; Dziura, James; Zhou, Jing

doi:10.1016/j.jdermsci.2012.04.003

Cited by 19 publications

(15 citation statements)

References 32 publications

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“…Recently, Milstone et al [29] used three mouse models expressing a transgene in the epidermis to show that local changes in iron metabolism in the epidermis can have a measurable impact on systemic iron metabolism. Similarly, our current studies also demonstrate that Fpn Epi-KO mice exhibit a more rapid decrease in blood hemoglobin concentration than control mice on a low iron diet.…”

Section: Discussionmentioning

confidence: 99%

Epidermal iron metabolism for iron salvage

Asano

Yamasaki

Yamauchi

et al. 2017

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 99%

Epidermal iron metabolism for iron salvage

Asano

Yamasaki

Yamauchi

et al. 2017

Journal of Dermatological Science

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“…Yet overall, the daily loss of iron by desquamation is approximately 25% that of daily urinary iron excretion ( Molin and Wester, 1976 ). Evidence is emerging from genetic model mouse studies by Milstone et al (2012) that both loss of iron by desquamation and local changes in epidermal iron metabolism have some role in systemic iron metabolism (these studies investigated three groups of mice: firstly mice overexpressing of HPV16 E7 gene, which causes a threefold increase in epidermal turnover, secondly mice overexpressing the transferrin receptor which causes a three to fourfold increase of epidermal iron in a skin model, and finally a systemic hemochromatosis knockout model crossed with the epidermal iron sink model). Additionally, gender-related differences in iron status may be responsible for the increased longevity of women as compared to men.…”

Section: Role Of Iron In the Skinmentioning

confidence: 99%

“… Normal physiology of iron homeostasis. Figure adapted to show key iron physiology including iron loss by desquamation (see Milstone et al, 2012 ). …”

Section: Role Of Iron In the Skinmentioning

confidence: 99%

The role of iron in the skin and cutaneous wound healing

2014

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In this review article we discuss current knowledge about iron in the skin and the cutaneous wound healing process. Iron plays a key role in both oxidative stress and photo-induced skin damage. The main causes of oxidative stress in the skin include reactive oxygen species (ROS) generated in the skin by ultraviolet (UVA) 320–400 nm portion of the UVA spectrum and biologically available iron. We also discuss the relationships between iron deficiency, anemia and cutaneous wound healing. Studies looking at this fall into two distinct groups. Early studies investigated the effect of anemia on wound healing using a variety of experimental methodology to establish anemia or iron deficiency and focused on wound-strength rather than effect on macroscopic healing or re-epithelialization. More recent animal studies have investigated novel treatments aimed at correcting the effects of systemic iron deficiency and localized iron overload. Iron overload is associated with local cutaneous iron deposition, which has numerous deleterious effects in chronic venous disease and hereditary hemochromatosis. Iron plays a key role in chronic ulceration and conditions such as rheumatoid arthritis (RA) and Lupus Erythematosus are associated with both anemia of chronic disease and dysregulation of local cutaneous iron hemostasis. Iron is a potential therapeutic target in the skin by application of topical iron chelators and novel pharmacological agents, and in delayed cutaneous wound healing by treatment of iron deficiency or underlying systemic inflammation.

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“…Another study 136 highlights the direct correlation between the stage of skin exfoliation (dyskeratosis) and the level of iron in the skin. Yet another study analyses the toxic effects derived from iron overload in many diseases, including connective tissue disease (Lupus, rheumatoid arthritis) 137 and in the wound healing process.…”

Section: Iron and Free Iron In The Chronic Venous Insufficiencymentioning

confidence: 99%

The role of free iron in cardiovascular diseases. Part II

Izzo¹,

Gasbarro²,

Coscia³

2017

JTAVR

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This work is the second part of a review on the role of free iron forms in cardiovascular diseases. Here, we stress on various aspects related to the iron form that are free of poorly chelated to iron biocarriers, as for example the NTBI (Non Transferrin Bound Iron). We report on problems relating the determination of such free iron forms and, after all, on their implications in cardiac diseases as well as in venous insufficiency.

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Impact of epidermal desquamation on tissue stores of iron

Cited by 19 publications

References 32 publications

Epidermal iron metabolism for iron salvage

Epidermal iron metabolism for iron salvage

The role of iron in the skin and cutaneous wound healing

The role of free iron in cardiovascular diseases. Part II

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