Impact of epilepsy and antiepileptic drugs on health and quality of life in Indian children

Nagabushana, Divya; Praveen-kumar, S.; Agadi, Jagadish B.

doi:10.1016/j.yebeh.2019.01.021

Cited by 28 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epilepsy adversely affected the QOL that was not in consonance of some studies done in the past where most of the respondents reported their health status as good, 12 although majority of other studies reported to have lower QOL in children with epilepsy. [13][14][15][16][17][18] The most common type of epilepsy in the present study was generalized (87%) that was also reported in other Indian studies. In this study, it was found that QOL in the cognitive dimension of epileptic children was more affected than physical, social, and emotional dimensions.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Quality of Life in Children with Epilepsy

Prajapati

Dwivedi

Bajaj

2020

Journal of Pediatric Epilepsy

View full text Add to dashboard Cite

Abstract Objective The main aim of this study was to assess quality of life in children with epilepsy. Materials and Methods A prospective observational study was conducted in Regional Early Intervention Centre of the Department of Pediatrics Tertiary Care Hospital in central India. This study included 120 children with epilepsy aged between 2 and 18 years. In this study, we assessed the quality of life in children with epilepsy with the help of Pediatric Quality of Life Inventory (PedsQL). We further analyzed the quality of life in various dimensions. For the statistical analyses for SPSS version, 20 was used, chi-squared and Fisher's exact test was used for categorical variables, and Student's t-test was used for quantitative variables. Linear regression analysis was done for multivariate analysis. Result Mean total PedsQL score for total cohort was 70.96. The cognitive dimension of epileptic children was more affected than physical, social, and emotional dimensions. Factors associated with lower PedsQL scores in epilepsy patients were associated with long duration of epilepsy, polytherapy, male gender, low head circumference, presence of intellectual disability, and refractory epilepsy. Conclusion Epilepsy affects the quality of life in children across all age groups. Among epilepsy indicators, polytherapy, refractory epilepsy, and duration of epilepsy were the most important factors associated with poor quality of life. We can conclude that every effort should be made to decrease the duration of treatment and minimize the number of drugs for improving the quality of life in this patient cohort.

show abstract

Section: Discussionsupporting

confidence: 89%

“…On multivariate analysis, IQ score and long duration of epilepsy were most strongly associated with poor QOL that was also found in a recently published study. 15 Our study had the following limitations: 1. PedsQL is not validated in Indian population; so, scores used may not reasonably reflect QOL in India.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Children with Epilepsy

Prajapati

Dwivedi

Bajaj

2020

Journal of Pediatric Epilepsy

View full text Add to dashboard Cite

show abstract

“…In addition, CWE who had experienced AED side effects had lower quality of lives compared with those who had not which is similar to other studies. [14][15][16] These findings highlight the impact of the severity of the disease and proper management of seizures on the QoL of CWE. The duration of seizure episodes was not associated with the QoL which is consistent with some other studies.…”

Section: Discussionmentioning

confidence: 90%

Comparison of Health-Related-Quality-of-Life among Children with Epilepsy and a Healthy Control Group in Tehran

Abdollahi

Abbasi‐Kangevari

Kolahi

et al. 2020

Journal of Pediatric Neurology

View full text Add to dashboard Cite

The objective of this study was to determine the quality-of-life (QoL) among children with epilepsy in comparison with a healthy control group. Participants included mothers of 206 children with epilepsy and of 211 healthy controls. The QoL was measured via cross-cultural adaptation of the Quality-of-Life in Children with Epilepsy Questionnaire, which was also modified for the control group. The mean (standard deviation) overall QoL score of children with epilepsy was lower than that of the healthy control group at: 74.3 (8.2) versus 87.9 (6.6), p < 0.001. In addition, all seven dimensions of quality-of-life were lower among children with epilepsy compared with that of the healthy control group. The health-related QoL of children with epilepsy was lower than that of the healthy control group. Children experiencing seizures more frequently, experiencing side effects from antiepileptic drugs, having a history of hospitalization, and having poor school performance displayed lower scores in QoL, which may highlight the impact of the severity of the disease and proper management of seizures on the quality-of-life in children with epilepsy.

show abstract

“…It is very important to evaluate the well-being and quality of life of children with epilepsy (Bilgiç et al, 2018;Conde-Guzón et al, 2020;Momen et al, 2019). Studies have emphasized that children with epilepsy have lower quality of life compared to their healthy peers due to factors, such as seizure attacks, frequency and severity of seizures, unpredictable time of seizures, side effects associated with antiepileptic drug (AEDs) treatment, and perceived stigma associated with epilepsy (De La Loge et al, 2016;Jovanovic et al, 2015;Love et al, 2016;Momen et al, 2019;Nagabushana et al, 2019). However, it has also been reported that apart from the effects of seizures, emotional and behavioral problems experienced by children with epilepsy further reduce the health-related quality of life (Reilly et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…HRQOL refers to an individual's perception of his/her position in life in the context of culture and value systems in which he/she lives and in relation to his/her goals, expectations, standards, and concerns (de Wit & Hajos, 2013). HRQOL measures encompass multiple areas of functioning of subjective wellbeing and are considered crucial to comprehensive management (Nagabushana et al, 2019).…”

Section: Introductionmentioning

confidence: 99%