Impact of Escitalopram on Nocturnal Sleep, Day-Time Sleepiness and Performance Compared to Amitriptyline: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Male Subjects

Doerr, John Peter; Spiegelhalder, Kai; Petzold, Friederike; Feige, Bernd; Hirscher, Verena; Kaufmann, Rainer; Riemann, Dieter; Voderholzer, Ulrich

doi:10.1055/s-0030-1249049

Cited by 19 publications

(13 citation statements)

References 46 publications

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“…Reported beta values of the linear model are differences, relative to PLA by the factor condition and regression coefficients for the serum levels. As already reported by Doerr et al .,28) ESC led to a significantly lower total sleep time (TST) and sleep efficiency (SE) compared to AMI. Wake time after sleep onset decreased after AMI compared to PLA and ESC and increased after ESC compared to PLA and AMI.…”

Section: Resultssupporting

confidence: 67%

“…they are not mediated by changes in ghrelin, leptin, cortisol or prolactin. This appears to be true as well for the decreased sleep continuity, suppressed REM sleep and improved daytime sleepiness and performance following ESC 28). The effects of AMI and ESC on REM sleep are well known and mainly induced by noradrenergic/serotoninergic and anticholinergic effects 42–44)…”

Section: Discussionmentioning

confidence: 83%

“…Assuming that early morning serum concentrations correlates with hormone concentrations during the preceding night and to further explore possible relationships of endocrine changes on polysomnographic nighttime sleep, daytime sleepiness (MSLT) and attention (TAP, D2), two linear regression models were employed with these dependent variables on already published polysomnographic findings from this trial 28). The intra- and interindividual influences on sleep and daytime performance are listed in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Polysomnographic findings from this trial have already been published 28). Two participants were excluded after the adaptation night (atrio-ventricular block, technical recording failure).…”

Section: Methodsmentioning

confidence: 99%

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Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Frase

Doerr

Feige

et al. 2018

Clin Psychopharmacol Neurosci

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ObjectiveThe primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans.MethodsEleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed.ResultsA repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA). Subsequent univariate analyses demonstrated significant condition effects for ghrelin and cortisol. Post-hoc analyses demonstrated a significant reduction of ghrelin levels after AMI in comparison to PLA, and a significant reduction of cortisol levels after AMI in comparison to both ESC and PLA. Other contrasts did not reach statistical significance.ConclusionAdministration of a single dose of AMI, but not of ESC, leads to a significant reduction in morning serum ghrelin and cortisol levels. No effects on leptin and prolactin levels were observed. The differential impact of AMI and ESC on hormones might contribute to different adverse effect profiles of both substances.

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Section: Resultssupporting

confidence: 67%

Section: Discussionmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Frase

Doerr

Feige

et al. 2018

Clin Psychopharmacol Neurosci

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“…Thus, the side effects (headache, nausea, diarrhea, dry mouth,31 sleepiness,32 insomnia, constipation33 and yawning34) were measured. All patients had no such side effects before this study.…”

Section: Participants and Methodsmentioning

confidence: 99%

Long-term bicycle riding ameliorates the depression of the patients undergoing hemodialysis by affecting the levels of interleukin-6 and interleukin-18

Zhao¹,

Ma²,

Yang³

et al. 2016

NDT

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PurposeHemodialysis patients with depression have a higher risk of death and hospitalization. Although there is pharmacological management for the depression of hemodialysis patients, the adverse effect of the drug limits the use. The nonpharmacological way, bicycle riding, may be an effective way for the therapy of the depression in hemodialysis patients. However, the underlying mechanism of this relationship is still not fully explained, while interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with depression and exercise. Thus, the effects of bicycle riding on the levels of the interleukin were explored.Participants and methodsOne hundred and eighty-nine patients with chronic hemodialysis were selected and randomly assigned to three groups of medicine (MG, received 20-mg escitalopram daily), medicine and aerobic exercise (MAG, received 20-mg escitalopram daily and bicycle riding six times weekly), and only aerobic exercise (AG, received 20-mg placebo daily and bicycle riding six times weekly). The whole experiment lasted for 18 weeks. The quality of life (36-Item Short Form Health Survey) and depression severity according to criteria in the Diagnostic and Statistical Manual of Mental Disorders, fourth edition [DSM-IV] were measured before and at the end of this study. The serum levels of IL-6 and IL-18 were measured by an enzyme-linked immunosorbent assay kit.ResultsThe quality of life was improved and depression severity was reduced significantly in the MAG and AG groups when compared with the MG group (P<0.05). Serum levels of IL-6 and IL-18 were the highest in the MG group, moderate in the MAG group and the lowest in AG group. On the other hand, the serum levels of IL-6 and IL-18 were closely associated with depression scores (P<0.05).ConclusionAerobic exercise improves the quality of life and ameliorates the depression severity of the patients undergoing hemodialysis by affecting the levels of IL-6 and IL-18. Bicycle riding is a potential way for the depression therapy of the patients with chronic hemodialysis.

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Assessment of Medication and Recreational Drugs Associated with Fatigue

2018

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Impact of Escitalopram on Nocturnal Sleep, Day-Time Sleepiness and Performance Compared to Amitriptyline: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Male Subjects

Abstract: This study demonstrates that single evening doses of either AMI or ESCIT exhibit different effects on next-day vigilance and alertness in terms of a slightly stimulating effect of ESCIT and a significant reduction after AMI.

Cited by 19 publications

References 46 publications

Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Long-term bicycle riding ameliorates the depression of the patients undergoing hemodialysis by affecting the levels of interleukin-6 and interleukin-18

Assessment of Medication and Recreational Drugs Associated with Fatigue

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