Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation

Wan, Huaibin; Wang, Juan; Yang, Yanmin; Fan, Xin; Chen, Dongdong; Bian, Ning

doi:10.1186/s12872-020-01786-6

Cited by 3 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with AF in China often experience renal failure, and those without valvular heart diseases (VHDs) have a poorer prognosis when their eGFR is lower. Close monitoring of renal function, adherence to anticoagulation guidelines, and aggressive prevention of renal impairment may improve the outcomes of these patients 37 .…”

Section: Glomerular Filtration Ratementioning

confidence: 99%

Association Between Biomarkers of Kidney Disorders and Atrial Fibrillation: A Literature Review

Rafaqat,

Sharif

2023

J Cardiac Arrhtythmias

View full text Add to dashboard Cite

Kidney diseases and atrial fibrillation often occur together. Renal impairment increases the risk of developing incident atrial fibrillation (AF) and is linked to it in a bidirectional manner, making it a prothrombotic and pro-hemorrhagic condition. In Japanese patients with nonvalvular AF, lower creatinine clearance values were associated with thromboembolism, all-cause death, and cardiovascular death, but not with major haemorrhage. Older individuals with elevated serum levels of cystatin C had a significantly higher prevalence of AF. Moderate to severe chronic kidney disease individuals with increased levels of fibroblast growth factor-23 were independently associated with prevalent and incident AF. A higher baseline glomerular filtration rate was associated with an increased risk of AF. Elevated levels of insulin-like growth factor binding protein-7 were also observed in AF patients, while reduced circulating tissue inhibitor of metalloproteinase 2 levels were also associated with an increased risk of AF. Patients with AF had higher levels of non-esterified fatty acids and liver type fatty acid binding protein. Interleukin-18 levels in blood plasma were also found to be higher in AF patients. Furthermore, higher baseline urea/blood urea nitrogen levels were significantly associated with the incidence of AF in women and kidney disease in both men and women.

show abstract

Section: Glomerular Filtration Ratementioning

confidence: 99%

Association Between Biomarkers of Kidney Disorders and Atrial Fibrillation: A Literature Review

Rafaqat,

Sharif

2023

J Cardiac Arrhtythmias

View full text Add to dashboard Cite

show abstract

“…Subsequent to a first event (eg, stroke), patients potentially had a higher risk of experiencing repeated cardiovascular events or death. The probabilities of repeated cardiovascular events [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] (Table S2) and relative risks for intensive treatment compared with standard treatment 39 (Table S3) were derived from the published literature.…”

Section: Data Sourcesmentioning

confidence: 99%

Cost-Effectiveness of Intensive Versus Standard Blood Pressure Treatment in Older Patients With Hypertension in China

et al. 2022

View full text Add to dashboard Cite

Background: In the STEP trial (Strategy of Blood Pressure Intervention in older Hypertensive Patients), the risk of cardiovascular events is significantly lower in patients who received intensive systolic blood psressure (BP) treatment than in those who received standard treatment. This study compared the lifetime health benefits and medical costs of intensive BP treatment with those of standard BP treatment. Methods: A microsimulation model included 10 000 hypothetical samples of Chinese adults aged 60 to 80 years old with baseline systolic BP higher than 140 mm Hg. Primary outcome was the incremental cost-effectiveness ratio from a payer’s perspective. Secondary outcome was cardiovascular events, including acute coronary syndrome, stroke, acute decompensated heart failure, atrial fibrillation, and death from cardiovascular causes. Results: The model simulated that cardiovascular events occurred in 36.88% of the patients in the intensive treatment group, as compared to 41.28% of the patients in the standard treatment group over the lifetime horizon. The mean number of quality-adjusted life-years would be 0.16 higher in patients who received intensive treatment than in those who received standard treatment and would cost Chinese yuan 12 614 (International dollars 3018) more per quality-adjusted life-year gained. Most simulation results indicated that intensive treatment would be cost-effective (82%–95% below the willingness-to-pay threshold of Chinese yuan 72 000 [1× the gross domestic product per capita in China in 2020]). Sensitivity analyses showed that these conclusions were robust. Conclusions: In this study, intensive BP treatment prevented cardiovascular events among older patients with hypertension in China and was cost-effective in most scenarios. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03015311

show abstract

Effect of Genetic Variants, Gender, and Co-treatment on Olanzapine Plasma Concentration in Chinese patients with schizophrenia

Chen

Lyu

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose Given the inter-individual variability in dose-corrected concentrations observed in olanzapine used, this study aimed to find factors that may have contributed to the variation in patients.Methods The trough plasma concentrations of olanzapine were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). All the patients enrolled were on steady olanzapine doses for at least two weeks. Our study simultaneously investigated the association of gender, co-treatment, kidney function, body weight, and UGT1A4, UGT2B7, UGT2B15, CYP1A2, CYP2D6 variants on olanzapine dose-corrected concentrations (C/DOLZ) in 117 Chinese patients with schizophrenia.Results Multiple linear regression analyses suggested that gender, co-treatment with sodium valproate, and UGT1A4 variants had significantly affected C/DOLZ in inpatients with schizophrenia (P༜0.05). Females showed higher C/DOLZ levels compared to males, co-treatment with VPA exhibited lower C/DOLZ levels, UGT1A4 variants showed its significance (P = 0.005) in the multiple linear regression,Conclusions The results revealed that gender, co-treatment with VPA, and UGT1A4 variants significantly influenced C/DOLZ levels. This study provided some combined effects, especially genotype and co-treatment information, for clinicians to remind them when prescribing OLZ. The variability of C/DOLZ levels suggests that TDM could be a helpful tool in addition to a thorough clinical follow-up.

show abstract

Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation

Cited by 3 publications

References 20 publications

Association Between Biomarkers of Kidney Disorders and Atrial Fibrillation: A Literature Review

Association Between Biomarkers of Kidney Disorders and Atrial Fibrillation: A Literature Review

Cost-Effectiveness of Intensive Versus Standard Blood Pressure Treatment in Older Patients With Hypertension in China

Effect of Genetic Variants, Gender, and Co-treatment on Olanzapine Plasma Concentration in Chinese patients with schizophrenia

Contact Info

Product

Resources

About