Impact of etanercept treatment on ultraviolet B-induced inflammation, cell cycle regulation and DNA damage

Gambichler, Thilo; Tigges, Christian; Dith, A.; Skrygan, Marina; Scola, Nina; Altmeyer, Peter; Kreuter, Alexander

doi:10.1111/j.1365-2133.2010.10099.x

Cited by 27 publications

(15 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Survivin protects against apoptosis and regulates the progression of cell cycle, therefore, it is conceivable that, survivin plays an important role in the pathogenesis of psoriasis. Upregulation of survivin has been observed in the epidermis of psoriatic patients who were treated with narrow-band UVB combined with etanercept (tumor necrosis factor-a inhibitor), suggesting the survivin-dependent increased risk of skin cancer formation in psoriatic patients who undergo this type of combined therapy [24].…”

Section: Discussionmentioning

confidence: 99%

The role of survivin in oral squamous cell carcinoma

Liang¹,

Guo²,

Liu³

2018

biomedicalresearch

View full text Add to dashboard Cite

Tumor samples were collected from 30 patients who were suffered with squamous cell carcinoma of the oral cavity. The patients were treated by radical surgical resection between 2012 and 2015 at the Jinling hospital. There were 24 patients who were positive for survivin (80.0%) and 6 patients who were negative for survivin (20.0%). Compared with normal mucosa, there were significantly up-regulated survivin and caspase 9 in OSCC which were proved by Flow Cytometry (FCM) and western blot, respectively. In conclusion, survivin and Caspase 9 might be prognostic markers for Oral Squamous Cell Carcinoma (OSCC).

show abstract

Section: Discussionmentioning

confidence: 99%

The role of survivin in oral squamous cell carcinoma

Liang¹,

Guo²,

Liu³

2018

biomedicalresearch

View full text Add to dashboard Cite

show abstract

“…In one study, BB‐UVB therapy had a higher rate of carcinogenesis, while in another, NB‐UVB therapy had a higher rate of carcinogenesis, revealing inconsistent results. One study suggested that the combined use of biologics and BB‐UVB therapy promotes photocarcinogenesis …”

Section: Chapter V: Strength Of Recommendations and Comments For Eachmentioning

confidence: 99%

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Fujita

Terada

Hayama

et al. 2018

The Journal of Dermatology

198

456

View full text Add to dashboard Cite

Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and systemic flushing accompanied by extensive sterile pustules. The committee of the guidelines was founded as a collaborative project between the Japanese Dermatological Association and the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labour, and Welfare Research Project on Overcoming Intractable Diseases. The aim of the guidelines was to provide current information to aid in the treatment of patients with GPP in Japan. Its contents include the diagnostic and severity classification criteria for GPP, its pathogenesis, and recommendations for the treatment of GPP. Since there are few clinical trial data with high levels of evidence for this rare disease, recommendations by the committee are described in the present guidelines.

show abstract

“…In skin treated with erythemogenic doses [2 minimal erythemal doses (MEDs)] of UVB, immunoreactivity of cyclin D1 and p53 was significantly decreased at 24 h, and survivin expression was significantly higher if ETN was administered simultaneously . Furthermore, another anti‐TNF‐α inhibitor, the chimeric monoclonal antibody infliximab, was found to impair the repair of photoinduced cyclobutane pyrimidine dimer in the spontaneously immortalized, nontumorigenic human keratinocyte cell line HaCaT …”

Section: Discussionmentioning

confidence: 99%

Synergism between narrowband ultraviolet B phototherapy and etanercept for the treatment of plaque-type psoriasis

et al. 2013

View full text Add to dashboard Cite

SummaryBackground Previous investigations have demonstrated that a combination of etanercept (ETN) and narrowband ultraviolet B (NB-UVB) phototherapy is more effective than ETN alone. However, it is unclear if this combination is more effective than NB-UVB phototherapy alone. Objectives To evaluate whether the combination of NB-UVB phototherapy with ETN improves the efficacy of ETN alone in the treatment of moderate-to-severe psoriasis. Methods We enrolled 322 consecutive patients with moderate-to-severe plaquetype psoriasis, who were treated with NB-UVB phototherapy as the first-line treatment option. Patients who did not achieve a 75% improvement in Psoriasis Area and Severity Index (PASI 75) were treated with conventional systemic therapies for psoriasis. If they were ineligible for these, they were treated with ETN 50 mg twice weekly. If they did not achieve PASI 75 within 12 weeks, NB-UVB phototherapy was added. Results PASI 75 was achieved in 262 patients (81Á4%) treated with NB-UVB phototherapy. Sixteen patients (5Á0%) dropped out for personal reasons and 24 (7Á5%) were treated with at least one of the conventional systemic treatments for psoriasis. Twenty patients (6Á2%) were treated with ETN. The combination regimen was needed in eight patients (2Á5%) with poor response to both phototherapy and ETN alone. All of these patients achieved PASI 75 and three of them had a complete remission after 14Á6 AE 3Á3 NB-UVB exposures. The combined treatment was well tolerated without acute adverse events. Unfortunately, all of these patients relapsed, with PASI > 10 within 2Á8 AE 1Á7 months. Conclusions The combined treatment has a synergistic effect for clearing plaquetype psoriasis previously unresponsive to ETN and NB-UVB phototherapy alone. The clearance rate is very high in a very short time without short-term adverse effects. However, concerns regarding potential cocarcinogenicity remain. Therefore the number of patients who require, and could benefit from, the combined treatment is likely to be small.

show abstract

Impact of etanercept treatment on ultraviolet B-induced inflammation, cell cycle regulation and DNA damage

Abstract: Our data indicate that combined treatment with broadband UVB and TNF-α blockers might increase the risk of photocarcinogenesis by influencing apoptotic as well as antiapoptotic pathways.

Cited by 27 publications

References 28 publications

The role of survivin in oral squamous cell carcinoma

The role of survivin in oral squamous cell carcinoma

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Synergism between narrowband ultraviolet B phototherapy and etanercept for the treatment of plaque-type psoriasis

Contact Info

Product

Resources

About