Impact of excluding hyperglycemia from international diabetes federation metabolic syndrome diagnostic criteria on prevalence of the syndrome and its association with microvascular complications, in adult patients with type 1 diabetes

Lecumberri, Edurne; Nattero‐Chávez, Lía; Silva, Jhonatan Quiñones; Díaz, Sara Alonso; Fernández‐Durán, Elena; Avendaño, Beatriz Dorado; Escobar-Morreale, Héctor F.; Luque‐Ramírez, Manuel

doi:10.1007/s12020-022-03041-8

Cited by 4 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering that the rates of T1DM and T2DM are similar in Indigenous children and adolescents [ 6 ], it is possible that T1DM cases were included in those studies and may have biased associations. Modified MetS criteria have been recommended for individuals with T1DM [ 104 ], which future studies should consider. However, as young people with T1DM have lower BMI on average than those with T2DM [ 6 ], our finding that obesity is associated with elevated glucose, insulin and diabetes is unlikely to be impacted by this potential bias.…”

Section: Discussionmentioning

confidence: 99%

Potential Determinants of Cardio-Metabolic Risk among Aboriginal and Torres Strait Islander Children and Adolescents: A Systematic Review

McKay

O’Bryan

Gubhaju

et al. 2022

IJERPH

View full text Add to dashboard Cite

Prevention initiatives during childhood and adolescence have great potential to address the health inequities experienced by Aboriginal and Torres Strait Islander (Indigenous) populations in Australia by targeting modifiable risk factors for cardio-metabolic diseases. We aimed to synthesize existing evidence about potential determinants of cardio-metabolic risk markers—obesity, elevated blood pressure, elevated blood glucose, abnormal lipids, or a clustering of these factors known as the metabolic syndrome (MetS)—for Indigenous children and adolescents. We systematically searched six databases for journal articles and three websites for relevant grey literature. Included articles (n = 47) reported associations between exposures (or interventions) and one or more of the risk markers among Indigenous participants aged 0–24 years. Data from 18 distinct studies about 41 exposure–outcome associations were synthesized (by outcome: obesity [n = 18]; blood pressure [n = 9]; glucose, insulin or diabetes [n = 4]; lipids [n = 5]; and MetS [n = 5]). Obesity was associated with each of the other cardio-metabolic risk markers. Larger birth size and higher area-level socioeconomic status were associated with obesity; the latter is opposite to what is observed in the non-Indigenous population. There were major gaps in the evidence for other risk markers, as well as by age group, geography, and exposure type. Screening for risk markers among those with obesity and culturally appropriate obesity prevention initiatives could reduce the burden of cardio-metabolic disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Potential Determinants of Cardio-Metabolic Risk among Aboriginal and Torres Strait Islander Children and Adolescents: A Systematic Review

McKay

O’Bryan

Gubhaju

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…This also raises the question of whether this glycaemic criterion could be supported by or replaced with other markers indicating the presence of insulin resistance in individuals with type 1 diabetes. This problem was addressed by Lecumberri et al They showed that the prevalence of MS among type 1 diabetic patients is lower when using standard IDF criteria and when excluding hyperglycaemia as a criterion [ 24 ]. Moreover, they proposed the modification of the MS definition in T1D, including the assessment of IR by using indirect insulin resistance markers [ 24 ].…”

Section: In the Double Diabetes Definition Does Metabolic Syndrome Tr...mentioning

confidence: 99%

“…This problem was addressed by Lecumberri et al They showed that the prevalence of MS among type 1 diabetic patients is lower when using standard IDF criteria and when excluding hyperglycaemia as a criterion [ 24 ]. Moreover, they proposed the modification of the MS definition in T1D, including the assessment of IR by using indirect insulin resistance markers [ 24 ]. Another disadvantage of using MS definitions is the lack of cohesion among them.…”

Section: In the Double Diabetes Definition Does Metabolic Syndrome Tr...mentioning

confidence: 99%

Double diabetes—when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition

Bielka,

Przezak,

Molęda

et al. 2024

Cardiovasc Diabetol

View full text Add to dashboard Cite

Currently, the differentiation between type 1 diabetes (T1D) and type 2 diabetes (T2D) is not straightforward, and the features of both types of diabetes coexist in one subject. This situation triggered the need to discriminate so-called double diabetes (DD), hybrid diabetes or type 1.5 diabetes, which is generally described as the presence of the insulin resistance characteristic of metabolic syndrome in individuals diagnosed with T1D. DD not only raises the question of proper classification of diabetes but is also associated with a significantly greater risk of developing micro- and macroangiopathic complications, which was independent of glycaemic control. When considering the global obesity pandemic and increasing incidence of T1D, the prevalence of DD may also presumably increase. Therefore, it is of the highest priority to discover the mechanisms underlying the development of DD and to identify appropriate methods to prevent or treat DD. In this article, we describe how the definition of double diabetes has changed over the years and how it is currently defined. We discuss the accuracy of including metabolic syndrome in the DD definition. We also present possible hypotheses connecting insulin resistance with T1D and propose possible methods to identify individuals with double diabetes based on indirect insulin resistance markers, which are easily assessed in everyday clinical practice. Moreover, we discuss adjuvant therapy which may be considered in double diabetic patients.

show abstract

“…Hyperglycemia might lead to damage in various tissues and organs throughout the body and is a significant contributing factor to kidney failure, neuropathy and cardiovascular disease [ 76 ]. Quite a few studies have demonstrated that consumption of pulse proteins and their hydrolysates can enhance glucose metabolism and reduce fasting blood glucose levels [ 77 ].…”

Section: Pulse Proteins and Their Hydrolysates For Improving Metsmentioning

confidence: 99%

Pulse Proteins and Their Hydrolysates: A Comprehensive Review of Their Beneficial Effects on Metabolic Syndrome and the Gut Microbiome

Hong,

Fan,

et al. 2024

Nutrients

View full text Add to dashboard Cite

Pulses, as an important part of the human diet, can act as a source of high-quality plant proteins. Pulse proteins and their hydrolysates have shown promising results in alleviating metabolic syndrome and modulating the gut microbiome. Their bioactivities have become a focus of research, with many new findings added in recent studies. This paper comprehensively reviews the anti-hypertension, anti-hyperglycemia, anti-dyslipidemia and anti-obesity bioactivities of pulse proteins and their hydrolysates in recent in vitro and in vivo studies, which show great potential for the prevention and treatment of metabolic syndrome. In addition, pulse proteins and their hydrolysates can regulate the gut microbiome, which in turn can have a positive impact on the treatment of metabolic syndrome. Furthermore, the beneficial effects of some pulse proteins and their hydrolysates on metabolic syndrome have been supported by clinical studies. This review might provide a reference for the application of pulse proteins and their hydrolysates in functional foods or nutritional supplements for people with metabolic syndrome.

show abstract

Impact of excluding hyperglycemia from international diabetes federation metabolic syndrome diagnostic criteria on prevalence of the syndrome and its association with microvascular complications, in adult patients with type 1 diabetes

Cited by 4 publications

References 30 publications

Potential Determinants of Cardio-Metabolic Risk among Aboriginal and Torres Strait Islander Children and Adolescents: A Systematic Review

Potential Determinants of Cardio-Metabolic Risk among Aboriginal and Torres Strait Islander Children and Adolescents: A Systematic Review

Double diabetes—when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition

Pulse Proteins and Their Hydrolysates: A Comprehensive Review of Their Beneficial Effects on Metabolic Syndrome and the Gut Microbiome

Contact Info

Product

Resources

About