2019
DOI: 10.1371/journal.pone.0212132
|View full text |Cite
|
Sign up to set email alerts
|

Impact of exposure to diesel exhaust during pregnancy on mammary gland development and milk composition in the rabbit

Abstract: Exposure to fine-particulate air pollution is a major global health concern because it is associated with reduced birth weight and an increased risk of cardiovascular disease. Here we have investigated the potential for exposure to diesel exhaust during pregnancy to influence mammary gland development and milk composition. Female rabbits were therefore exposed by nose-only inhalation to either diluted diesel exhaust fumes (1 mg/m 3 ) or clean air for 2h/day, 5 days/week, from the 3 … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
6
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 8 publications
(6 citation statements)
references
References 62 publications
0
6
0
Order By: Relevance
“…We hypothesized that similar changes may occur in breastmilk composition affected by air pollution. Thus far, only one animal study analyzed the influence of exposure to diesel exhaust during pregnancy on mammary gland development and breastmilk composition [224]. The authors found that maternal exposure did not alter mammary gland histology and leptin expression, but affected the expression of the stearoyl-CoA desaturase ( SCD ) gene involved in lipid metabolism, and therefore, an alteration of the milk lipid and protein profile was found [224].…”
Section: Findings and Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We hypothesized that similar changes may occur in breastmilk composition affected by air pollution. Thus far, only one animal study analyzed the influence of exposure to diesel exhaust during pregnancy on mammary gland development and breastmilk composition [224]. The authors found that maternal exposure did not alter mammary gland histology and leptin expression, but affected the expression of the stearoyl-CoA desaturase ( SCD ) gene involved in lipid metabolism, and therefore, an alteration of the milk lipid and protein profile was found [224].…”
Section: Findings and Discussionmentioning
confidence: 99%
“…Thus far, only one animal study analyzed the influence of exposure to diesel exhaust during pregnancy on mammary gland development and breastmilk composition [224]. The authors found that maternal exposure did not alter mammary gland histology and leptin expression, but affected the expression of the stearoyl-CoA desaturase ( SCD ) gene involved in lipid metabolism, and therefore, an alteration of the milk lipid and protein profile was found [224]. Moreover, studies on maternal tobacco smoking showed that mothers who smoked produced less milk and breastfed for a shorter time, probably due to changes in hormone levels; affected suckling in infants; and had a higher risk of lactation problems (e.g., mastitis) [223].…”
Section: Findings and Discussionmentioning
confidence: 99%
“…Previous work suggests that exposure to air pollution impacts breastmilk composition. For example, an experimental study demonstrated that rabbits exposed to diesel particulate matter during pregnancy led to the development of fat globules in the mammary glands as well as increased expression of genes for enzymes involved in lipid biosynthesis 32 . Due to the importance of genetic factors in synthesizing HMOs, there is biological plausibility that exposure to air pollution may impact HMO production and composition.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, geography has been linked to differences in HMO profiles 9 , 30 , as have residential green environments 31 . Air pollution exposure has also been found to impact human milk composition, including lipid biosynthesis 32 . Given the genetic underpinnings of HMO biosynthesis, exposure to air pollution might modulate epigenetic pathways 33 , 34 , subsequently influencing HMO production within mammary glands.…”
Section: Introductionmentioning
confidence: 99%
“…To the best of our knowledge no other investigations of relationships between wildfire-derived PM and milk composition have been published. However, subjecting pregnant rabbits to urban levels of fine particulates in diesel exhaust altered mammary nutrient metabolism and consequently the protein and fatty acid profiles of milk during early lactation (Hue-Beauvais et al, 2019). The mechanisms involved in PM effects on milk yield and composition are unclear but may be associated with impairment of mammary gland development or cellular turnover, or endocrine or metabolism disruption, as has been demonstrated for the toxic effects of other chemical compounds on a variety of tissues (Heindel et al, 2017).…”
Section: Milk Production and Metabolismmentioning
confidence: 99%