Impact of extended use and decontamination with vaporized hydrogen peroxide on N95 respirator fit

Lieu, Anthony; Mah, Jordan; Zanichelli, Veronica; Exantus, Rose Carmel; Longtin, Yves

doi:10.1016/j.ajic.2020.08.010

Cited by 26 publications

(48 citation statements)

References 7 publications

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“…All included studies analyzed N95 model FFRs. 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 Additionally, 1 investigation employed FFR P100, 7 another used PFF-3, 20 and 7 also used surgical masks. 5 , 16 , 21 , 22 , 23 , 31 , 41 More than half of the studies included in this review received funding.…”

Section: Resultsmentioning

confidence: 99%

“…The preservation of material integrity was assessed in 22 studies (55.0%). 4 , 5 , 7 , 10 , 13 , 15 , 17 , 19 , 20 , 21 , 22 , 23 , 25 , 26 , 28 , 29 , 30 , 33 , 35 , 39 , 41 , 44 It can be observed that the use of hydrogen peroxide, 4 , 13 , 19 , 32 , 35 especially Hydrogen Peroxide Gas Plasma, 4 , 19 and high-temperature methods 10 , 15 , 16 , 19 , 23 , 25 , 26 , 28 , 41 were strongly associated with integrity degradation. Sodium hypochlorite also damaged the FFRs, causing stains, discoloration, dissolution of the nose seal comfort pad, oxidation, and stiffening of the filter and elastic 7 , 10 , 15 , 16 , 19 ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 40 studies included, 24 4 , 7 , 8 , 10 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 23 , 25 , 26 , 27 , 28 , 30 , 33 , 35 , 36 , 38 , 40 , 41 , 42 had their FFR sample composed of different models and/or manufacturers. Three studies 5 , 9 , 16 did not mention whether they worked with the same models or brands of FFR.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Safety in the practice of decontaminating filtering facepiece respirators: A systematic review

Gnatta

Souza

Lemos

et al. 2021

American Journal of Infection Control

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Background Considering the new SARS-CoV-2 pandemic and the potential scarcity of material resources, the reuse of personal protective equipment such as filtering facepiece respirators (FFRs) for N95 filtering or higher is being discussed, mainly regarding the effectiveness and safety of cleaning, disinfection and sterilization processes. Aim To analyze the available evidence in the literature on the safety in processing FFRs. Methods A systematic review conducted by searching for studies in the following databases: PubMed, CINAHL, LILACS, CENTRAL, EMBASE, Web of Science, and Scopus. Results Forty studies were included in this review. The disinfectant/sterilizing agents most frequently tested at different concentrations and exposure periods were ultraviolet irradiation, vaporized hydrogen peroxide and steam sterilization. Microbial reduction was assessed in 21 (52.5%) studies. The only disinfectants/sterilizers that did not caused degradation of the material-integrity were alcohol, electric cooker, ethylene oxide, and peracetic acid fogging. Exposure to ultraviolet irradiation or microwave generated-steam resulted in a nonsignificant reduction in filter performance. Conclusion There is a complex relationship between the FFR raw materials and the cycle conditions of the decontamination methods, evidencing the need for validating FFRs by models and manufacturers, as well as the process. Some methods may require additional tests to demonstrate the safety of FFRs for use due to toxicity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Safety in the practice of decontaminating filtering facepiece respirators: A systematic review

Gnatta

Souza

Lemos

et al. 2021

American Journal of Infection Control

View full text Add to dashboard Cite

show abstract

“…Hydrogen peroxide Hydrogen peroxide was evaluated in its liquid, plasma and gas/vapor forms by nineteen laboratory studies. 33,[40][41][42][43][44]48,52,[58][59][60][61][62]65,66,69,73,75,76 . The effect of hydrogen peroxide on the ltering capacity varied according to the method used.…”

Section: Resultsmentioning

confidence: 99%

Mask decontamination methods (model N95) for respiratory protection: a rapid review

Probst

Guerrero

Cardoso

et al. 2021

Preprint

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Background: N95 respiratory protection masks are used by healthcare professionals to prevent contamination from infectious microorganisms transmitted by droplets or aerosols.Methods: We conducted a rapid review of the literature analyzing the effectiveness of decontamination methods for mask reuse. The database searches were carried out up to September 2020. The systematic review was conducted in a way which simplified the stages of a complete systematic review, due to the worldwide necessity on reliable fast evidences on this matter.Results: A total of 563 articles were retrieved of which 48 laboratory-based studies were selected. Fifteen decontamination methods were included in the studies. A total of 19 laboratory studies used Hydrogen peroxide, 21 studies used ultraviolet germicidal irradiation,4 studies used ethylene oxide, 11 studies used dry heat, 9 studies used moist heat, 5 studies used ethanol, two studies used isopropanol solution, 11 studies used microwave oven, 10 studies used sodium hypochlorite, seven studies used autoclave, three studies used electric rice cooker, one study used cleaning wipes, one study used bar soap, one study used water, one study used multi-purpose high-level disinfection cabinet and another one used chlorine dioxide. Five methods promising: hydrogen peroxide vapor, ultraviolet irradiation, dry heat, wet heat/pasteurization, and microwave ovens.Conclusions: We have presented the best available evidence on masks decontamination, nevertheless, its applicability are limited due to few studies on the topic and lack of studies on real environments.

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“…Hydrogen peroxide Hydrogen peroxide was evaluated in its liquid, plasma and gas/vapor forms by nineteen laboratory studies. 28,[35][36][37][38][39]43,47,[53][54][55][56][57]60,61,64,68,70,71 The effect of hydrogen peroxide on the ltering capacity varied according to the method used. Hydrogen peroxide plasma led to changes in the masks' metallic nasal clips 61 and degradation in their ltering performance.…”

Section: Characterization Of the Included Studiesmentioning

confidence: 99%

Decontamination methods for respiratory protection mask model N95: a rapid review

Probst

Guerrero

Cardoso

et al. 2020

Preprint

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Background: N95 respiratory protection masks are used by healthcare professionals to prevent contamination with infectious microorganisms transmitted by droplets or aerosols.Methods: We conducted a rapid review of the literature analyzing the effectiveness of decontamination methods for mask reuse. The review was carried out in September 2020 using a simplification of the formal systematic review process, which simplified the stages of a complete systematic review, including the exclusion of an assessment of study methodology.Results: A total of 563 articles were retrieved of which 48 laboratory-based studies were selected. Fifteen decontamination methods were included in the studies. Hydrogen peroxide was evaluated by 19 laboratory studies, ultraviolet germicidal irradiation by 21, ethylene oxide by 4, dry heat by 11, moist heat by 9, ethanol by 5, isopropanol solution by 2, microwave oven by 11, sodium hypochlorite by 10, autoclave by 7, electric rice cooker by 3, cleaning wipes by 1, bar soap and water 1, multi-Purpose High-Level Disinfection Cabinet by 1 and chlorine dioxide by 1. Five methods appear promising: hydrogen peroxide vapor, ultraviolet irradiation, dry heat, wet heat/pasteurization, and microwave ovens.Conclusions: Positive results should be considered with caution as they represent a small number of studies, reflect ideal laboratory conditions, and may have limited applicability in realistic situations and for health systems.

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Impact of extended use and decontamination with vaporized hydrogen peroxide on N95 respirator fit

Cited by 26 publications

References 7 publications

Safety in the practice of decontaminating filtering facepiece respirators: A systematic review

Safety in the practice of decontaminating filtering facepiece respirators: A systematic review

Mask decontamination methods (model N95) for respiratory protection: a rapid review

Decontamination methods for respiratory protection mask model N95: a rapid review

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