Impact of family history on the presentation and clinical outcomes of coronary heart disease: data from the Korea Acute Myocardial Infarction Registry

Kim, Choongki; Chang, Hyuk Jae; Cho, Iksung; Sung, Ji Min; Choi, Donghoon; Jeong, Myung Ho; Jang, Yangsoo

doi:10.3904/kjim.2013.28.5.547

Cited by 22 publications

(11 citation statements)

References 30 publications

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“…17 A study in South Korea showed that patients with a family history of ischaemic heart disease were younger and more likely to be male. 18 In the present study, having a family history of ischaemic heart disease was associated with more cardiovascular events (p=0.035).…”

Section: Discussionsupporting

confidence: 46%

Validation of the GRACE Risk Score for Acute Coronary Syndrome Patients in an Asian Medical Centre

Lim

Cheong

et al. 2022

J Asian Pac Soc Cardiol

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Background: The Global Registry of Acute Coronary Syndrome (GRACE) risk score is used to provide an estimate of 6-month mortality among patients admitted for acute coronary syndrome (ACS). Methods: This study validated the GRACE score in a contemporary cohort of 428 patients aged ≥18 years admitted to Hospital Sultanah Aminah Johor Bahru between January and April 2018 for ACS. The survival status of patients 6 months after hospital discharge was calculated using the GRACE risk score, and the validity of the GRACE risk score was evaluated by assessing its calibration (Hosmer–Lemeshow test) and discriminatory capacity. Results: Of the 428 patients in this study, 92 (21.5%) were admitted for ST-elevation MI (STEMI), 128 (29.9%) were admitted for non-STEMI and 208 (48.6) were admitted for unstable angina. By 6 months after discharge, 66 (15%) patients had died. The GRACE risk score was calibrated and validated, showing an adequate capacity for discrimination with a receiver operating characteristic area under the curve of 0.831 (95% CI [0.778–0.884]; p<0.001). Conclusion: This study validated the GRACE score for predicting 6-month mortality among patients admitted to an Asian medical centre for ACS and recommended that it is used routinely.

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Section: Discussionsupporting

confidence: 46%

Validation of the GRACE Risk Score for Acute Coronary Syndrome Patients in an Asian Medical Centre

Lim

Cheong

et al. 2022

J Asian Pac Soc Cardiol

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“…Gender differences in the impact of family history on IHD risk have been controversial. In a multivariate analysis of traditional Framingham risk factors, family history was predictive of major adverse CVD events in women but there was no significant increased risk in men 47 . A larger study showed gender differences as well.…”

Section: Non-framingham Risk Factorsmentioning

confidence: 89%

Ischemic heart disease in women: A focus on risk factors

Mehta

Wei

Wenger

2015

Trends in Cardiovascular Medicine

165

108

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Heart disease remains a major contributor to morbidity and mortality in women in the United States and worldwide. This review highlights known and emerging risk factors for ischemic heart disease (IHD) in women. Traditional Framingham risk factors such as hypertension, hyperlipidemia, diabetes, smoking, as well as lifestyle habits such as unhealthy diet and sedentary lifestyle are all modifiable. Health care providers should be aware of emerging cardiac risk factors in women such as adverse pregnancy outcomes, systemic autoimmune disorders, obstructive sleep apnea, and radiation-induced heart disease; psychosocial factors such as mental stress, depression, anxiety, low socioeconomic status, and work and marital stress play an important role in IHD in women. Appropriate recognition and management of an array of risk factors is imperative given the growing burden of IHD and need to deliver cost-effective, quality care for women.

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“…Genetic factors play a significant role in the occurrence and progression of many diseases, such as coronary heart disease ( 37 , 38 ), diabetes ( 39 ) and diabetes insipidus ( 40 ). However, it is very difficult to screen causative genes through pedigrees, and there is no unified and standardized method.…”

Section: Discussionmentioning

confidence: 99%

A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity

et al. 2022

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BackgroundAs genetic genetic factors are important in SLE, so screening causative genes is of great significance for the prediction and early prevention in people who may develop SLE. At present, it is very difficult to screen causative genes through pedigrees. The analytical method described herein can be used to screen causative genes for SLE and other complex diseases through pedigrees.MethodsFor the first time, 24 lupus pedigrees were analyzed by combining whole exon sequencing and a variety of biological information tools including common-specific analysis, pVAAST (pedigree variant annotation, analysis and search tool), Exomiser (Combining phenotype and PPI associated analysis), and FARVAT (family based gene burden), and the causative genes of these families with lupus identified. Selected causative genes in peripheral-blood mononuclear cells (PBMCs) were evaluated by quantitative polymerase chain reaction (qPCR).ResultsCell division cycle 27 (CDC27) was screened out by common-specific analysis and Exomiser causative gene screening. FARVAT analysis on these families detected only CDC27 at the extremely significant level (false discovery rate <0.05) by three family-based burden analyses (BURDEN, CALPHA, and SKATO). QPCR was performed to detect for CDC27 in the PBMCs of the SLE family patients, sporadic lupus patients, and healthy people. Compared with the healthy control group, CDC27 expression was low in lupus patients (familial and sporadic patients) (P<0.05) and correlated with lupus activity indicators: negatively with C-reactive protein (CRP) (P<0.05) and erythrocyte sedimentation rate (P<0.05) and positively with complement C3 and C4 (P<0.05). The CDC27 expression was upregulated in PBMCs from SLE patients with reduced lupus activity after immunotherapy (P<0.05). Based on Receiver operating characteristic (ROC) curve analysis, the sensitivity and specificity of CDC27 in diagnosing SLE were 82.30% and 94.40%.ConclusionThe CDC27 gene, as found through WES combined with multiple analytical method may be a causative gene of lupus. CDC27 may serve as a marker for the diagnosis of SLE and is closely related to the lupus activity. We hope that the analytical method in this study will be used to screen causative genes for other diseases through small pedigrees, especially among non-close relatives.

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Impact of family history on the presentation and clinical outcomes of coronary heart disease: data from the Korea Acute Myocardial Infarction Registry

Cited by 22 publications

References 30 publications

Validation of the GRACE Risk Score for Acute Coronary Syndrome Patients in an Asian Medical Centre

Validation of the GRACE Risk Score for Acute Coronary Syndrome Patients in an Asian Medical Centre

Ischemic heart disease in women: A focus on risk factors

A Novel Gene CDC27 Causes SLE and Is Associated With the Disease Activity

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