Impact of Fatigue in Parkinson’s Disease: The Fatigue Impact Scale for Daily Use (D-FIS)

Martinez‐Martín, Pablo; Catalán, María José; Benito‐León, Julián; Moreno, Angel Ortega; Zamarbide, Ivana; Cubo, Esther; Blercon, Nadeje van; Arillo, V. Campos; Pondal, Margarita; Linazasoro, Gurutz; Alonso, F.; Ruiz, Pedro; Frades, Belén

doi:10.1007/s11136-005-4181-0

Cited by 79 publications

(81 citation statements)

References 51 publications

(70 reference statements)

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“…The MFI has been widely used for patients with PD. 1,2,11,24 In the present study (N 5 77), the MFI proved to be a reliable intrument to assess fatigue (ICCs 5 0.70-0.87).…”

Section: Measuring Fatiguesupporting

confidence: 48%

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Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?

et al. 2009

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To investigate the longitudinal association between fatigue and physical activity in Parkinson's disease (PD) and determine whether this association is distorted by potential confounders. Data from baseline, 3, 6, and 12 week assessments in a single blind randomized clinical trial with cross-over design were used (N = 153). The Multidimensional Fatigue Inventory (MFI) was used to assess fatigue and an activity monitor to measure amount of physical activity (defined as % dynamic activity during each monitoring session). Time-independent and time-dependent factors were investigated for their possible univariate association with dynamic activity. Random coefficient analysis was applied. Candidate confounders were successively added to the longitudinal association model to determine if the association between dynamic activity and fatigue was distorted. A proportional change beyond 15% was considered to be significant. Fatigue was significantly associated with physical activity (beta = -0.099, SE = 0.032, P = 0.002). This association was not significantly distorted by type of intervention, age, gender, social support, disease duration, disease severity, motor impairment, cognition, anxiety, or medication intake. Depression caused proportional change of 22.2% in the regression coefficient of MFI. After controlling for depression, a significant association between MFI and dynamic activity remained (beta = -0.121, SE = 0.036, P = 0.000). The association found between fatigue and dynamic activity suggests that patients who experience higher levels of fatigue are less physically active. However, the total explained variance of dynamic activity by fatigue alone was small, suggesting that fatigue is only a minor factor in the complex of behavioral aspects that affect the amount of physical activity in patients with PD.

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“…The MFI has been widely used for patients with PD. 1,2,11,24 In the present study (N 5 77), the MFI proved to be a reliable intrument to assess fatigue (ICCs 5 0.70-0.87).…”

Section: Measuring Fatiguesupporting

confidence: 48%

“…[1][2][3] Prevalence rates reported in the literature range from 32% to 50%. 4,5 Fatigue is often believed to be an independent factor that is negatively associated with activities in patients with PD.…”

Section: Fatigue Is Common In Many Patients With Idiopathicmentioning

confidence: 99%

Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?

et al. 2009

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“…Pavese et al [20] further discuss that due to an effective loss of SERT protein found in their study, SSRI are less likely to be efficacious in PD patients with primary fatigue. A previous observational study by Martinez-Martin et al [43] found a lower prevalence of fatigue in patients treated with amantadine, which is often used to treat fatigue in multiple sclerosis as well. In our study we did not find an association between amantadine intake and any of the fatigue domains in either the primary or secondary fatigue groups.…”

Section: Discussionmentioning

confidence: 94%

Clinical determinants of primary and secondary fatigue in patients with Parkinson’s disease

et al. 2013

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Clinical and psychosocial factors associated separately with primary and secondary fatigue in Parkinson's disease (PD) patients have not been thoroughly studied before. The aim of our study was to assess factors associated with different fatigue domains in groups with primary and secondary fatigue in PD separately. We divided 165 nondemented PD patients according to the absence/presence of depression, anxiety and excessive somnolence into groups with primary fatigue (N = 63) and with secondary fatigue (N = 102). Fatigue domains examined using the multidimensional fatigue inventory were associated through multiple linear regression analyses for each group separately with sociodemographic data, disease duration, functional status as assessed by the Unified Parkinson's Disease Rating Scale, treatment, depression, anxiety, excessive somnolence and sleep quality. Out of the assessed non-motor symptoms, fatigue was the most frequent (77.6 %). The prevalence of fatigue in the secondary fatigue group was significantly higher than in the primary fatigue group. Both fatigue groups differed significantly in factors associated with different fatigue domains. Functional status or other disease-related factors were not associated with primary fatigue. In the secondary fatigue group, we found associations between some fatigue domains and functional status, older age, male gender and higher anxiety scores. To our knowledge, this is the first study to separately describe clinical determinants and psychosocial factors associated with different fatigue domains in primary and secondary fatigue in PD, underlining the importance of distinguishing primary and secondary fatigue in future PD studies and clinical practice.

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“…Total score ranges from 0 and 32 points. The D-FIS questionnaire has been translated into Spanish and adequately validated (29), and has previously been used in celiac disease (30).…”

Section: Assessment Of Fatiguementioning

confidence: 99%

Transcultural adaptation and validation of the Celiac Disease Quality of Life (CD-QOL) survey, a specific questionnaire to measure quality of life in patients with celiac disease

Casellas

Rodrigo

Molina–Infante

et al. 2013

Rev. esp. enferm. dig.

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Introduction: celiac disease is a chronic condition that requires continued treatment, with the resultant impact on health-related quality of life (HRQOL) of people who suffer it. Most studies in this field have used generic questionnaires to measure HRQOL in celiac patients. It was therefore decided to conduct a study to translate into Spanish and validate a specific questionnaire for celiac disease, the Celiac Disease Quality Of Life Survey (CD-QOL).Objectives: to translate and validate in Spanish the specific celiac disease questionnaire CD-QOL.Methods: a multicenter, prospective, observational study was designed consisting of two phases: In the first phase, the questionnaire was translated and adapted into Spanish using the translation/back translation procedure and an understandability study. In the second phase, internal consistency of the translated questionnaire was analyzed. For this, results of the CD-QOL were compared to those of EuroQol and the Daily Fatigue Impact Scale (D-FIS). Understandability of the translated and adapted questionnaire was tested in six patients, and the validation study was done in 298 celiac patients (201 treated with a gluten-free diet and 97 at diagnosis).Results: in both celiac groups, Cronbach's alpha coefficient was high (0.90), feasibility was excellent (99.2 % of patients completed all questions), and there were no ceiling and floor effects. Spearman correlation to EuroQol and D-FIS was statistically significant (p < 0.05). CD-QOL score was different depending on whether state of health was good, fair, or poor based on the EuroQol score.Conclusion: the Spanish version of the CD-QOL is a valid tool for measuring HRQOL in celiac patients.

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Impact of Fatigue in Parkinson’s Disease: The Fatigue Impact Scale for Daily Use (D-FIS)

Cited by 79 publications

References 51 publications

Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?

Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson's disease?

Clinical determinants of primary and secondary fatigue in patients with Parkinson’s disease

Transcultural adaptation and validation of the Celiac Disease Quality of Life (CD-QOL) survey, a specific questionnaire to measure quality of life in patients with celiac disease

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