Impact of fatigue on quality of life in patients with Parkinson’s disease

Havlíková, Eva; Rosenberger, Jaroslav; Nagyová, Iveta; Middel, Berry; Dubayová, Tatiana; Gdovinová, Zuzana; Dijk, van Jitse; Groothoff, Johan W.

doi:10.1111/j.1468-1331.2008.02103.x

Cited by 83 publications

(68 citation statements)

References 31 publications

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“…REM sleep behavioral disorder, restless legs syndrome and periodic movements of the legs are prevalent conditions in PD patients and are putative causes of excessive daytime sleepiness (36). In the present study, fatigue and excessive daytime sleepiness were not associated and the same was observed by others (27,37).…”

Section: Resultssupporting

confidence: 77%

Fatigue in a cohort of geriatric patients with and without Parkinson's disease

Goulart

Godke

Borges

et al. 2009

Braz J Med Biol Res

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We evaluated the frequency of fatigue in geriatric patients with and without Parkinson's disease (PD) and correlated it with depression and excessive daytime sleepiness. We evaluated 100 patients from Hospital São Paulo, 50 with PD from the Neurologic Outpatient Clinic and 50 with non-neurologic diseases or oncologic diseases from the Geriatric Outpatient Clinic (controls). All patients who scored 28 or more on the Fatigue Severity Scale (FSS) were considered to have fatigue. Also, all patients were submitted to a structured interview to diagnose depression by the criteria of the American Psychiatric Association (DSM-IV, 4th version) and were evaluated by the Modified Impact of Fatigue Scale and the Epworth Sleepiness Scale (ESE) to detect excessive daytime sleepiness. Demographic and disease details of all PD patients were recorded and the patients were examined and rated by the Unified Parkinson's Disease Rating Sale (UPDRS) and Hoehn-Yahr staging. Frequency of fatigue (FSS ≥28) was 70% for PD and 22% for controls. Twenty of 35 PD patients with fatigue had concomitant depression. Compared to controls, PD patients were found more frequently to have depression by DSM-IV criteria (44 vs 8%, respectively) and excessive daytime sleepiness by the ESE (44 vs 16%), although only depression was associated with fatigue. Fatigue was more frequent among depressed PD and control patients and was not correlated with PD duration or with UPDRS motor scores. ESE scores did not differ between patients with or without fatigue.

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Section: Resultssupporting

confidence: 77%

Fatigue in a cohort of geriatric patients with and without Parkinson's disease

Goulart

Godke

Borges

et al. 2009

Braz J Med Biol Res

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“…Fatigue was found to be the most frequent of all non-motor symptoms assessed in 1,072 consecutive patients examined in the PRIAMO study [2]. Fatigue also has a significant impact on quality of life [3,4]. In one of the first studies on fatigue in PD, 15-33 % of patients rated it as their most disabling symptom, and more than half rated fatigue among their three worst symptoms [5].…”

Section: Introductionmentioning

confidence: 99%

Clinical determinants of primary and secondary fatigue in patients with Parkinson’s disease

et al. 2013

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Clinical and psychosocial factors associated separately with primary and secondary fatigue in Parkinson's disease (PD) patients have not been thoroughly studied before. The aim of our study was to assess factors associated with different fatigue domains in groups with primary and secondary fatigue in PD separately. We divided 165 nondemented PD patients according to the absence/presence of depression, anxiety and excessive somnolence into groups with primary fatigue (N = 63) and with secondary fatigue (N = 102). Fatigue domains examined using the multidimensional fatigue inventory were associated through multiple linear regression analyses for each group separately with sociodemographic data, disease duration, functional status as assessed by the Unified Parkinson's Disease Rating Scale, treatment, depression, anxiety, excessive somnolence and sleep quality. Out of the assessed non-motor symptoms, fatigue was the most frequent (77.6 %). The prevalence of fatigue in the secondary fatigue group was significantly higher than in the primary fatigue group. Both fatigue groups differed significantly in factors associated with different fatigue domains. Functional status or other disease-related factors were not associated with primary fatigue. In the secondary fatigue group, we found associations between some fatigue domains and functional status, older age, male gender and higher anxiety scores. To our knowledge, this is the first study to separately describe clinical determinants and psychosocial factors associated with different fatigue domains in primary and secondary fatigue in PD, underlining the importance of distinguishing primary and secondary fatigue in future PD studies and clinical practice.

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“…The results of previous studies show that fatigue severity is inversely related to physical activity, functional status, and quality of life (15,17,19,20). It also increases the rate and risk of falls and is highly correlated with fear of falling (18,21).…”

Section: Introductionmentioning

confidence: 88%

“…It is one of the 3 most bothersome symptoms in more than half of PD patients and is the most disabling symptom in 15% -33% of these patients (15). A higher level of fatigue is related to safety concerns, such as a higher risk of falls, cognitive deficits, and reduced quality of life in PD patients (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Safety Predictors in Performance of Activities of Daily Living in Patients with Parkinson’s Disease

Heris

Akbarfahimi

Lajevardi

2017

Middle East J Rehabil Health Stud

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Background: Safety is recognized as an important factor in personal independence. The aim of this study was to determine the association of factors, such as fatigue, duration of disease, age, dominant involved body side, gender, and severity of disease with safety performance and to identify safety predictors among effective factors for activities of daily living (ADL) among patients with Parkinson's disease (PD). Methods: Sixty patients with PD participated in this study. Fatigue was assessed using the 16-item Parkinson fatigue scale (PFS-16), while performance safety was examined with the performance assessment of self-care skills (PASS). Linear multiple regression analysis was performed between PASS safety parameter as the dependent variable and independent variables with significant correlations with performance safety, using SPSS version 18.

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Impact of fatigue on quality of life in patients with Parkinson’s disease

Abstract: Fatigue combined with worse functional status appears to be a significant contributor to poor quality of life. Its multidimensional construct can be used to develop strategies for improving specific aspects of fatigue to improve QoL for PD patients.

Cited by 83 publications

References 31 publications

Fatigue in a cohort of geriatric patients with and without Parkinson's disease

Fatigue in a cohort of geriatric patients with and without Parkinson's disease

Clinical determinants of primary and secondary fatigue in patients with Parkinson’s disease

Safety Predictors in Performance of Activities of Daily Living in Patients with Parkinson’s Disease

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