Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup

Fujii, Makoto; Ohno, Yuko; Yamada, Makoto; Kamada, Y.; Miyoshi, Eiji

doi:10.1186/s12199-019-0763-2

Cited by 39 publications

(28 citation statements)

References 48 publications

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“…An earlier study from the United States found that individuals with chronic pancreatitis alone ( n = 35) had a significantly greater IPFD in comparison with controls ( n = 50) in a post-hoc analysis constrained to non-obese people only (body mass index < 30 kg/m 2 )[ 33 ]. A longitudinal study from Japan sought to investigate the temporal relationship between IPFD and chronic pancreatitis[ 34 ]. A total of 9933 individuals without pancreatitis were examined in 2008 and followed up for 4 years as part of their medical check-up.…”

Section: Excess Body Fatmentioning

confidence: 99%

“…A total of 9933 individuals without pancreatitis were examined in 2008 and followed up for 4 years as part of their medical check-up. The presence of fatty pancreas disease at baseline was associated with a 3.9-times higher risk of incident pancreatitis during follow-up (odds ratio 3.9; 95% confidence interval 2.0 to 7.7), after adjustment for age, sex, body mass index, glycated hemoglobin, systolic blood pressure, alcohol abuse, tobacco smoking, and other covariates[ 34 ]. However, it is worth noting that transabdominal ultrasound was used in this study, which is suboptimal for diagnosing of both chronic pancreatitis and fatty pancreas disease.…”

Section: Excess Body Fatmentioning

confidence: 99%

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Post-pancreatitis diabetes mellitus and excess intra-pancreatic fat deposition as harbingers of pancreatic cancer

Petrov¹

2021

WJG

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Progress in the fight against pancreatic cancer has been hampered by many factors. One of them is the inability to detect the disease early in overwhelming majority of patients. The present paper outlines a novel way in which progress could be accelerated. This includes a focus on two harbingers—post-pancreatitis diabetes mellitus and excess intra-pancreatic fat deposition—that converge at affecting the tumor macroenvironment and microenvironment specifically in the pancreas, not other organs. The two entities have the potential to be incorporated into future screening strategies with a view to early detecting of pancreatic cancer.

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Section: Excess Body Fatmentioning

confidence: 99%

Section: Excess Body Fatmentioning

confidence: 99%

Post-pancreatitis diabetes mellitus and excess intra-pancreatic fat deposition as harbingers of pancreatic cancer

Petrov¹

2021

WJG

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“…18,19 The role of NAPS is still debatable in acute and chronic pancreatitis, pancreatic cancer, and pancreatic exocrine insufficiency. 20 Older age, high BMI, and insulin resistance are reportedly associated with NAPS, 9,12,21,22 although some studies have found no relation between NAPS and beta-cell function. 23 Fat infiltration of the pancreas may lead to more bleeding and post-operative fistula formation in pancreatic surgery.…”

Section: Discussionmentioning

confidence: 99%

Does Nonalcoholic Pancreatic Steatosis Always Correlate with Nonalcoholic Fatty Liver Disease?

Ulasoglu

Tekin

Akan

et al. 2021

CEG

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Purpose To identify the correlation of nonalcoholic pancreatic steatosis (NAPS) with nonalcoholic fatty liver disease (NAFLD) in an outpatient group. Based on its metabolic and imaging properties, NAPS has been increasingly recognized in recent years; however, its interaction with NAFLD is still not clear. Patients and Methods In this cross-sectional observational study, 345 consecutive patients without any chronic illness who were referred to the senior radiologist for abdominal ultrasound (US) were included. The US report showed hepatic and pancreatic echogenicity. The patients’ demographic, anthropometric, and laboratory data were collected from medical records. Results Overall, NAPS and NAFLD were seen in 227 (65.8%) and 219 (63.5%) patients, respectively. Normal echogenicity was noted in 74 (21.4%) patients. Forty-four patients (12.8%) had steatotic liver without NAPS, 52 (15.1%) had steatotic pancreas without NAFLD, and 175 (50.7%) had steatosis in both organs. The discordance in steatosis grading between NAPS and NAFLD was 55.1%. Insulin resistance was present in 8.7, 26.7, 19, and 61.3% of patients with no steatosis, only NAFLD, only NAPS, and steatosis in both organs, respectively. Evident NAFLD and NAPS having grade 2 and 3 steatosis were present in 15.3% and 29.0% of the study group, respectively. Cholecystolithiasis was present in 6.8, 13.6, and 28.8% of patients with normal echogenic pancreas, only NAFLD, and only NAPS, respectively (p=0.01). Conclusion Based on the ultrasonographic, clinical, demographic, and anthropometric features of the included patients, we found that NAPS did not fully accompany nonalcoholic fatty liver. Despite severe pancreatic steatosis, more than a quarter of cases had normal liver echogenicity. Insulin resistance frequency was insignificantly higher in NAFLD than NAPS (p=0.694). The significantly higher frequency of cholecystolithiasis in NAPS needs further large-scale studies. The inconsistency of steatosis degree in NAPS and NAFLD in >50% cases may reflect differences in the pathophysiology of these two clinical entities.

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“…At the same time, this is also a challenge in obese patients to exhibit an apparent pancreas[ 44 ]. Pancreatic fat accumulation appears hyperechoic as compared with liver or kidney accumulation, a reference point for diagnosis[ 45 , 46 ]. Some studies have established that echogenicity of retroperitoneal fat suggests a higher amount of pancreatic fat deposition, using a grading system[ 22 , 25 , 7 ].…”

Section: Diagnosis Of Nafpdmentioning

confidence: 99%

Nonalcoholic fatty pancreas disease: An emerging clinical challenge

Zhang¹,

Wang²,

Li³

et al. 2021

WJCC

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Nonalcoholic fatty pancreas disease (NAFPD) is an emerging disease that has gained an increasing amount of attention in recent years. It describes fat accumulation in the pancreas with insignificant alcohol consumption, but the pathogenesis is largely unknown. A wide range of terms have been used to describe the phenomenon of pancreatic fat accumulation, but NAFPD remains an under-recognized and non-independent disorder. Obesity, age, sex, race, and unhealthy lifestyle are established independent risk factors for NAFPD, which is strongly associated with metabolic syndrome, type 2 diabetes, pancreatitis, pancreatic fistula, pancreatic cancer, and nonalcoholic fatty liver disease. At present, imaging techniques are common diagnostic aids, but uniform criteria and consensus are lacking. Therapeutically, healthy diet, weight loss, and exercise are the mainstays to reduce pancreatic fat accumulation. It can be seen that there is a limited understanding of NAFPD at this stage and further exploration is needed. Previous studies have revealed that NAFPD may directly affect diagnosis and clinical decision-making. Therefore, exploring the pathophysiological mechanism and clinical associations of NAFPD is a major challenge for researchers and clinicians.

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Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup

Cited by 39 publications

References 48 publications

Post-pancreatitis diabetes mellitus and excess intra-pancreatic fat deposition as harbingers of pancreatic cancer

Post-pancreatitis diabetes mellitus and excess intra-pancreatic fat deposition as harbingers of pancreatic cancer

Does Nonalcoholic Pancreatic Steatosis Always Correlate with Nonalcoholic Fatty Liver Disease?

Nonalcoholic fatty pancreas disease: An emerging clinical challenge

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