Impact of FDG-PET on the Detection of Patients with Lung Cancer at High Risk for ILD

Association between F-18 fluorodeoxyglucose uptake of noncancerous lung area and acute exacerbation of interstitial pneumonia in patients with lung cancer after resection

“…Recent clinical studies reported that high uptake values of F-18 FDG in the lung parenchyma of patients with IPF were associated with high mortality. 13,23 In the present study, multivariable analysis of the entire population and the 120 patients with IPF demonstrated that NCA-SUVmax was independently associated with postoperative AE, and the incidences of AE and SRAEs were 19.0% and 30.2%, respectively, for patients with IPF and NCA-SUVmax 1.69 or greater. All 12 patients with UIP who developed postoperative AE showed increased NCA-SUVmax values of greater than 1.69, whereas IPF categorization on CT showed a stronger association with NCA-SUVmax than Tumor-SUVmax.…”

“…12 Nobashi and colleagues 11 showed that increased F-18 FDG uptake in the lung parenchyma was associated with poor survival in patients with IP. Flechsig and colleagues 13 also showed that F-18 FDG-PET/computed tomography (CT) was able to detect patients at high risk for progressive IPs. These findings suggest that F-18 FDG uptake is likely to be associated with the severity of the fibrotic process, and there are common molecular mechanisms that causes DNA damage in both cancer and IPF.…”

Impact of Glucose Uptake of Noncancerous Lung Area in Respiratory Events for Lung Cancer Patients

“…In addition, F-18 FDG uptake in lung parenchyma has been shown to be related to CTdetermined inflammation severity and poor prognosis in patients with CILDs. 8,16 In this study, among patients with CILDs, the rate of SRAEs was higher in patients with NCA-SUVmax ! 1.3.…”

“…In addition, FDG uptake was correlated with the presence of idiopathic pulmonary fibrosis. 7,8 Flechsig and associates 8 showed that F-18 FDG-PET/CT was able to detect patients at high risk for progressive idiopathic pulmonary fibrosis. Another study has also reported that increased FDG accumulation was frequently shown in an abnormal lung field in CILDs.…”