Impact of fetal and childhood mercury exposure on immune status in children

Hui, Lucas Chi Kwong; Chan, Michael Ho Ming; Lam, Hugh Simon; Chan, Peggy Hiu Ying; Kwok, Ka Ming; Chan, Iris Hiu Shuen; Li, Albert Martin; Fok, Tai Fai

doi:10.1016/j.envres.2015.11.005

Cited by 32 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrary, the mean leptin level of this study (4.9 ng/mL) was comparable to levels in a Taiwanese study (4.6 ng/mL) [ 30 ], however, much lower compared to the study in Canada (19.8 ng/mL) [ 29 ]. Adiponectin and leptin levels vary among ethnicities according to the literature [ 31 ], this could explain relatively the lower leptin among the Asian population. Additionally, it is possible that difference in the prevalence of overweight women in this study and others may explain varied leptin levels among studies.…”

Section: Discussionmentioning

confidence: 99%

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Minatoya

Itoh

Araki

et al. 2018

IJERPH

View full text Add to dashboard Cite

Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels were measured and child behavioral problems were assessed using the Strengths and Difficulties Questionnaire at preschool age. Logistic regression models adjusted by related maternal factors were performed to examine the association between cord blood adipokines and child behavioral problems. Three hundred and sixty-one children were included in the final analysis. A significant association between decreased hyperactivity/inattention and increased leptin was found (OR = 0.22, 95% CI: 0.06–0.89). Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. Our findings suggested that cord blood adipokines, particularly, leptin level, may be a predictor of hyperactivity/inattention problems at preschool age.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Minatoya

Itoh

Araki

et al. 2018

IJERPH

View full text Add to dashboard Cite

show abstract

“…The health effects of mercury (Hg) exposure represent a significant threat to ecosystems and human welfare worldwide (Driscoll et al 2013 ), but understanding the risks associated with Hg exposure is complicated by this element’s varied environmental fate and the overarching influences of environmental, biological, and socioeconomic drivers. In its various forms, Hg causes immunotoxicity (Hawley et al 2009 ; Lewis et al 2013 ; Hui et al 2016 ; Zhang et al 2016 ; Crowe et al 2017 ) and nephrotoxicity (Tchounwou et al 2003 ), diminishes neurological capacity and neurobehavioral function (Steuerwald et al 2000 ; Basu et al 2005 ; Clarkson and Magos 2006 ; Mergler et al 2007 ; Scheuhammer and Sandheinrich 2008 ; Depew et al 2012a ; Bridges et al 2016 ; Landler et al 2017 ), alters functioning of three major endocrine axes (Wada et al 2009 ; Meyer et al 2014 ), and impairs reproduction and alters offspring quality (Klaper et al 2006 ; Burgess and Meyer 2008 ; Bergeron et al 2011 ; Hopkins et al 2013 ; Tartu et al 2013 ; Thompson et al in press). The numerous adverse health effects of Hg, coupled with the diverse environmental sources, propensity for long-range transport, complex biogeochemical cycling, and various exposure pathways through food webs and from industrial activities present significant challenges to characterizing and managing the risk of Hg exposure to ecological and public health.…”

Section: Introductionmentioning

confidence: 99%

Modulators of mercury risk to wildlife and humans in the context of rapid global change

Eagles‐Smith

Silbergeld

Basu

et al. 2018

Ambio

290

163

View full text Add to dashboard Cite

Environmental mercury (Hg) contamination is an urgent global health threat. The complexity of Hg in the environment can hinder accurate determination of ecological and human health risks, particularly within the context of the rapid global changes that are altering many ecological processes, socioeconomic patterns, and other factors like infectious disease incidence, which can affect Hg exposures and health outcomes. However, the success of global Hg-reduction efforts depends on accurate assessments of their effectiveness in reducing health risks. In this paper, we examine the role that key extrinsic and intrinsic drivers play on several aspects of Hg risk to humans and organisms in the environment. We do so within three key domains of ecological and human health risk. First, we examine how extrinsic global change drivers influence pathways of Hg bioaccumulation and biomagnification through food webs. Next, we describe how extrinsic socioeconomic drivers at a global scale, and intrinsic individual-level drivers, influence human Hg exposure. Finally, we address how the adverse health effects of Hg in humans and wildlife are modulated by a range of extrinsic and intrinsic drivers within the context of rapid global change. Incorporating components of these three domains into research and monitoring will facilitate a more holistic understanding of how ecological and societal drivers interact to influence Hg health risks.

show abstract

“… 2 Mercury ions cause cell dysfunction due to their strong affinity for enzymes and thiols in proteins. 3 Exposure to high levels of mercury in a long term can cause irreversible damage to the nervous system, 4 , 5 endocrine system, 6 immune system, 7 and digestive system. 8 Therefore, there is a great demand for new methods with high sensitivity and selectivity to monitor mercury in life systems and environments.…”

Section: Introductionmentioning

confidence: 99%

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Tian

Wang

et al. 2020

ACS Omega

View full text Add to dashboard Cite

Hg 2+ has a significant hazardous impact on the environment and ecosystem. There is a great demand for new methods with high selectivity and sensitivity to determine mercury in life systems and environments. In this paper, a novel turn-on Hg 2+ fluorescent probe has been reported with a naphthalimide group. The Hg 2+ fluorescent probe was designed by the inspiration of the well-known specific Hg 2+ -triggered thioacetal deprotection reaction. A 1,2-dithioalkyl group was chosen as the specific recognition site of Hg 2+ . The probe showed weak fluorescence without Hg 2+ , and the color of the solution was light yellow. In the presence of Hg 2+ , the probe reacted specifically with the mercury ion to produce an aldehyde and emitted strong fluorescence, and the color of the solution also turned light green, thus realizing the monitoring of the mercury ion. The Hg 2+ fluorescent probe showed outstanding sensitivity and selectivity toward Hg 2+ . Furthermore, the Hg 2+ fluorescent probe could work in a wide pH range. The linear relationship between the fluorescence intensity at 510 nm and the concentration of Hg 2+ was obtained in a range of Hg 2+ concentration from 2.5 × 10 –7 to 1.0 × 10 –5 M. The detection limit was found to be 4.0 × 10 –8 M for Hg 2+ . Furthermore, with little cell toxicity, the probe was successfully applied to the confocal image of Hg 2+ in PC-12 cells.

show abstract

Impact of fetal and childhood mercury exposure on immune status in children

Cited by 32 publications

References 48 publications

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Modulators of mercury risk to wildlife and humans in the context of rapid global change

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Contact Info

Product

Resources

About

Impact of fetal and childhood mercury exposure on immune status in children

Cited by 32 publications

References 48 publications

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Modulators of mercury risk to wildlife and humans in the context of rapid global change

A Highly Selective Fluorescent Probe for Hg2+ Based on a 1,8-Naphthalimide Derivative

Contact Info

Product

Resources

About

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative