Impact of Fetal Growth Restriction on Mortality and Morbidity in a Very Preterm Birth Cohort

Zeitlin, Jennifer; Ayoubi, Mayass El; Jarreau, Pierre Henri; Draper, Elizabeth S; Blondel, Béatrice; Künzel, W.; Cuttini, Marina; Kaminski, Monique; Gortner, Ludwig; Reempts, Patrick Van; Kollée, L.A.A.; Papiernik, E

doi:10.1016/j.jpeds.2010.05.002

Cited by 189 publications

(142 citation statements)

References 35 publications

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“…In this study, although we found a number of maternal diseases to be associated with being SGA, none of those factors showed significant associations with neonatal outcomes and hence were not included in later models. Our results are in line with those of another study (15), which showed that among a very preterm cohort stratifying for pregnancy complications yielded similar risk patterns; that is, BPD declined continuously with increasing birth weight. Our finding of stronger relationships using birth weight z-score rather than the binary outcome, above or below the 10th percentile, suggests that the 10th percentile is not a true threshold and that growth should be analyzed as a continuum.…”

Section: Discussionsupporting

confidence: 92%

Respiratory morbidity at follow-up of small-for-gestational-age infants born very prematurely

Peacock

D'Costa

et al. 2012

Pediatr Res

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Background:The aim of this study was to determine whether small-for-gestational-age (sGA) infants born very prematurely had increased respiratory morbidity in the neonatal period and at follow-up. Methods: Data were examined from infants recruited into the United Kingdom Oscillation study (UKOs). Of the 797 infants who were born at <29 wk of gestational age, 174 infants were sGA. Overall, 92% were exposed to antenatal corticosteroids and 97% received surfactant; follow-up data at 22-28 mo were available for 367 infants. results: After adjustment for gestational age and sex, sGA infants had higher rates of supplementary oxygen dependency at 36 wk postmenstrual age (odds ratio (OR): 3.23; 95% confidence interval: 2.03, 5.13), pulmonary hemorrhage (OR: 3.07; 95% cI: 1.82, 5.18), death (OR: 3.32; 95% cI: 2.13, 5.17), and postnatal corticosteroid requirement (OR: 2.09; 95% cI: 1.35, 3.23). After adjustment for infant and respiratory morbidity risk factors, a lower mean birth weight z-score was associated with a higher prevalence of respiratory admissions (OR: 1.40; 95% cI: 1.03, 1.88 for 1 sD change in z-score), cough (OR: 1.28; 95% cI: 1.00, 1.65), and use of chest medicines (OR: 1.32; 95% cI: 1.01, 1.73). conclusion: sGA infants who were born very prematurely, despite routine use of antenatal corticosteroids and postnatal surfactant, had increased respiratory morbidity at follow-up, which was not due to poor neonatal outcome.

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Section: Discussionsupporting

confidence: 92%

Respiratory morbidity at follow-up of small-for-gestational-age infants born very prematurely

Peacock

D'Costa

et al. 2012

Pediatr Res

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“…Of note, in our study, when the effect of the two main clinical presentations of placentation disorders (IUGR and hypertensive disease) was examined separately in comparison with spontaneous labor, the OR for IUGR (3.6) was higher than that for hypertensive disorders (2.6). It is known that SGA infants, a category largely caused by and overlapping with IUGR, are at increased risk of BPD (7,13,14,26). Recent data from a large prospective cohort showed that SGA is also associated with a poorer lung function in childhood among term infants, possibly linking infant size with lung size (27).…”

Section: Pregnancy Disorders and Neonatal Outcomementioning

confidence: 99%

Pregnancy disorders leading to very preterm birth influence neonatal outcomes: results of the population-based ACTION cohort study

Gagliardi

Rusconi

Frè³

et al. 2013

Pediatr Res

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“…5 BPD is strongly associated with low gestational age at birth [6][7][8] and low birth weight for gestational age. [9][10][11][12] Mechanical ventilation, oxygen therapy, patent ductus arteriosus, neonatal infection, male gender, and genetic factors are other risk factors. 10,13,14 Moreover, placentamediated pregnancy complications were recently suggested to be associated with BPD.…”

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confidence: 99%

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

et al. 2016

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OBJECTIVE: To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants.METHODS: National prospective population-based cohort study including 2697 singletons born before 32 weeks' gestation. The main outcome measure was moderate to severe BPD. Three groups of placenta-mediated pregnancy complications were compared with no placenta-mediated complications: maternal disorders only (gestational hypertension or preeclampsia), fetal disorders only (antenatal growth restriction), and both maternal and fetal disorders. RESULTS:Moderate to severe BPD rates were 8% in infants from pregnancies with maternal disorders, 15% from both maternal and fetal disorders, 23% from fetal disorders only, and 9% in the control group (P < .001). When we adjusted for gestational age, the risk of moderate to severe BPD was greater in the groups with fetal disorders only (odds ratio [OR] = 6.6; 95% confidence interval [CI], 4.1-10.7), with maternal and fetal disorders (OR = 3.7; 95% CI, 2.5-5.5), and with maternal disorders only (OR = 1.7; 95% CI, 1.0-2.7) than in the control group. When we also controlled for birth weight, the relationship remained in groups with fetal disorders only (OR = 4.2; 95% CI, 2.1-8.6) and with maternal and fetal disorders (OR = 2.1; 95% CI, 1.1-3.9).CONCLUSIONS: Placenta-mediated pregnancy complications with fetal consequences are associated with moderate to severe BPD in very preterm infants independently of gestational age and birth weight, but isolated maternal hypertensive disorders are not. Fetal growth restriction, more than birth weight, could predispose to impaired lung development.

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Impact of Fetal Growth Restriction on Mortality and Morbidity in a Very Preterm Birth Cohort

Cited by 189 publications

References 35 publications

Respiratory morbidity at follow-up of small-for-gestational-age infants born very prematurely

Respiratory morbidity at follow-up of small-for-gestational-age infants born very prematurely

Pregnancy disorders leading to very preterm birth influence neonatal outcomes: results of the population-based ACTION cohort study

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study

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