2018
DOI: 10.3174/ajnr.a5720
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Impact of Focal White Matter Damage on Localized Subcortical Gray Matter Atrophy in Multiple Sclerosis: A 5-Year Study

Abstract: WM tract disruption accounts for a small percentage of atrophy in connected subcortical gray matter when controlling for overall disease burden and is not the primary driver in most cases.

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Cited by 13 publications
(12 citation statements)
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“…Since the thalamus has broad network of afferent and efferent reciprocal connections with cortical and subcortical regions, the implicated axonal dying–back pathology would be the most apparent. Furthermore, these findings are in line with previous results which demonstrated that lesioned tract disruption is associated with specific increase in regional atrophy of the putamen . Future cortical parcellation of the study population may provide greater insight regarding associations between the axonal transection, sNfL levels, and atrophy of tract–specific deep GM and cortical surface regions.…”
Section: Discussionsupporting
confidence: 90%
“…Since the thalamus has broad network of afferent and efferent reciprocal connections with cortical and subcortical regions, the implicated axonal dying–back pathology would be the most apparent. Furthermore, these findings are in line with previous results which demonstrated that lesioned tract disruption is associated with specific increase in regional atrophy of the putamen . Future cortical parcellation of the study population may provide greater insight regarding associations between the axonal transection, sNfL levels, and atrophy of tract–specific deep GM and cortical surface regions.…”
Section: Discussionsupporting
confidence: 90%
“…Differently, the association of CCL18 with T2-LV in the whole MS population, and in particular in P-MS, would be mainly involved in the neurodegeneration mediated by focal lesions. Moreover, the association of this cytokine with GM volume loss in P-MS might be explained by both secondary antegrade (Wallerian) and retrograde neurodegeneration (31).…”
Section: Discussionmentioning
confidence: 99%
“…These findings are further corroborated by the fact that our PMS patients exhibited both numerically lower T2 lesion volume accrual and greater vCSF expansion rate over the 5-year follow-up period. Moreover, the thalamus, a highly interconnected brain hub, is particularly vulnerable structure affected by lesion-driven retrograde and/or anterograde (Wallerian) neurodegeneration [31]. Since the thalamus provides anatomical borders with the third ventricle and it is in the close proximity to the AoS, atrophic thalamus changes would significantly impact the AoS size.…”
Section: Discussionmentioning
confidence: 99%