Impact of formulation and operating parameters on particle size and grinding media wear in wet media milling of organic compounds – A case study for pyrene

Flach, Frederik; Konnerth, Christoph; Peppersack, Christoph; Schmidt, Jochen; Damm, Cornelia; Breitung‐Faes, Sandra; Kwade, Arno

doi:10.1016/j.apt.2016.09.026

Cited by 31 publications

(11 citation statements)

References 58 publications

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“…Smaller grinding media performed more efficient as it is typical for the fine grinding process at stress energies higher than the optimum stress energy. The same trend was observed in a former study on the influence of stress energy on the grinding behavior of pyrene . It is assumed that smaller stress energies are located closer to the optimum stress energy and, thus, being more efficient.…”

Section: Resultssupporting

confidence: 83%

“…Especially the experiments with the 900 mL disc mill showed a pronounced change of grinding kinetics at specific energy inputs above 100 000 kJ kg −1 . This can be attributed to grinding media wear because the generation of wear was found to be proportional to the energy input , , . Higher contamination levels by grinding media wear corresponding to a median particle size of 200 nm were generated within the 900 mL disc mill experiments.…”

Section: Resultsmentioning

confidence: 94%

“…Both materials were stabilized by a polymer‐surfactant combination using 25 wt % Kollidon VA 64 (KVA 64) from BASF and 2.5 wt % sodium dodecyl sulfate (SDS) purchased from Sigma Aldrich in relation to the mass of product particles. Grinding experiments were performed at constant pH range of 5 to 6 , .…”

Section: Methodsmentioning

confidence: 99%

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Scaling Wet Fine Grinding Processes of Organic Particles Using Stirred Media Mills

Flach

Breitung‐Faes

Kwade

2017

Chemie Ingenieur Technik

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This study presents an approach to scale up wet fine grinding processes of organic particles using stirred media mills. The process transfer is based on the calculation of grinding‐relevant energy, which is transferred to the product by a model theory derived from mill‐related values, especially geometric aspects. Its application was demonstrated by experimental work with two organic products, which were ground with different sizes and geometries of mills reaching from 20 to 900 mL grinding chamber volume under variation of process parameters.

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Section: Resultssupporting

confidence: 83%

Section: Resultsmentioning

confidence: 94%

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Scaling Wet Fine Grinding Processes of Organic Particles Using Stirred Media Mills

Flach

Breitung‐Faes

Kwade

2017

Chemie Ingenieur Technik

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“…Usually used as a binder, the O-(2-hydroxypropyl) cellulose (Hydroxypropyl Cellulose, HPC) revealed a new and unexpected activity as solubility enhancer for poorly soluble drugs. Recent papers described the successful application of HPC as solubilizing polymer for nano-suspensions and amorphous solid dispersions [1][2][3]. Ito and Konnerth [1,2], described in two papers the application of HPC and copovidone for the preparation of nano-suspensions where the best results were achieved with the low molecular weight HPC-SSL.…”

Section: Introductionmentioning

confidence: 99%

Differential Analysis of O-(2- hydroxypropyl) cellulose by Using Two-Dimensional 1H-NMR Spectroscopy

Sakamoto¹,

Stoyanov²

2020

Biomed Sci Eng

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Two-dimensional 1 H-NMR is used to determine the intra-molecular interactions of O-(2-hydroxypropyl) cellulose (HPC) in aqueous (D 2 O), DMF and DMSO solutions. Four grades HPC with different molecular weights are analyzed by using NOESY (Nuclear Overhauser Effect Spectroscopy) for proton-proton cross-interactions. A strong dependence of the polymer chain structure on the HPC Molecular Weight (MW) is overserved. The lower MW HPCs exist in solutions as a more linear chain showing less proton-proton interactions whereas the higher MW HPCs are more twisted and bended and form a tangled molecule mess with very intensive interactions between the -CH 3 , -CH 2 -and -C-H protons. From all the grades, the ultra-low molecular weight HPC-UL (MW 20,000) revealed the weakest proton-proton cross-relaxations and exists in solutions probably only as an almost linear chain polymer.

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“…In top‐down approaches, e.g., media milling, it is difficult to reach particle sizes of a few 10 nm and narrow particle size distributions (PSDs) . Furthermore, the risk of contaminating the product by attrition of milling media must be carefully considered .…”

Section: Introductionmentioning

confidence: 99%

Influence of Mixing on the Precipitation of Organic Nanoparticles: A Lagrangian Perspective on Scale‐up Based on Self‐Similar Distributions

Schikarski¹,

Trzenschiok²,

Avila

2019

Chem Eng & Technol

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Precipitation of nanoparticles is applied in various fields with a rising interest in the formulation of poorly soluble drugs. The impact of fluid mixing on the precipitation of organic nanoparticles is analyzed. Direct numerical simulations are applied to determine the spatiotemporal evolution of the liquid phase composition and to estimate the particle evolution along Langragian trajectories. The simulation results are compared with laboratory experiments of mixing and particle size evolution, which use a recently developed approach to rapidly stabilize the precipitated nanoparticles. The impact of mixing on precipitation is revealed, thereby enabling a parameter-free estimation of the mean particle sizes and the particle size distributions. The distributions of residence time, supersaturation time, and particle size are self-similar for Reynolds numbers in the turbulent regime and allow the derivation of scale-up rules.

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Impact of formulation and operating parameters on particle size and grinding media wear in wet media milling of organic compounds – A case study for pyrene

Cited by 31 publications

References 58 publications

Scaling Wet Fine Grinding Processes of Organic Particles Using Stirred Media Mills

Scaling Wet Fine Grinding Processes of Organic Particles Using Stirred Media Mills

Differential Analysis of O-(2- hydroxypropyl) cellulose by Using Two-Dimensional 1H-NMR Spectroscopy

Influence of Mixing on the Precipitation of Organic Nanoparticles: A Lagrangian Perspective on Scale‐up Based on Self‐Similar Distributions

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