Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease

Abstract

Brain frailty may be related to the pathophysiology of poor clinical outcomes in chronic obstructive pulmonary disease (COPD). This study examines the relationship between hippocampal subfield volumes and frailty and depressive symptoms, and their combined association with quality of life (QOL) in patients with COPD. The study involved 40 patients with COPD. Frailty, depressive symptoms and QOL were assessed using Kihon Checklist (KCL), Hospital Anxiety and Depression Scale (HADS), and World Health Organization Quality of Life Assessment (WHO/QOL-26). Anatomical MRI data were acquired, and volumes of the hippocampal subfields were obtained using FreeSurfer (version 6.0) (Harvard University, Boston, MA, USA). Statistically, HADS score had significant association with WHO/QOL-26 and KCL scores. KCL scores were significantly associated with volumes of left and right whole hippocampi, presubiculum and subiculum, but HADS score had no significant association with whole hippocampi or hippocampal subfield volumes. Meanwhile, WHO/QOL-26 score was significantly associated with volume of the left CA1. There was a significant association between frailty, depression, and QOL. Hippocampal pathology was related to frailty and, to some extent, with QOL in patients with COPD. Our results suggest the impact of frailty on hippocampal volume and their combined associations with poor QOL in COPD.

Hippocampal Subfield Volumes and Cognitive Function in Schizophrenia and Mood Disorders

“…The detailed scanning parameters have been described previously [30]. The volumes of hippocampal subfields were obtained using FreeSurfer software (version 6.0, https://surfer.nmr.mgh.harvard.edu/), which is widely used for patients with neuropsychiatric disease [41][42][43] and somatic disorder [44,45]. In the first step, "recon-all" processing was conducted in FreeSurfer.…”

Chronic Obstructive Pulmonary Disease: The Present and Future

“…Frequent exacerbator LABA, LAMA, ICS, roflumilast, macrolides Optimisation of comorbid physical and mental health conditions [27] Chronic bronchitis Roflumilast, mucolytics Use of CFTR modulators [13] Emphysema Lung volume reduction surgery Correction of miR overexpression [8] Type 1 respiratory failure Long-term oxygen therapy Increased vigilance for VTE in acute illness [29] Type 2 respiratory failure Domiciliary NIV Consideration of comorbidities such as OSA/ORRF [21] Eosinophilic COPD Steroids Identification of distinct microbiome in eosinophil-predominant COPD [15] Investigation of immunomodulatory alternatives to steroids [30] Bronchiectasis Targeted antibiotics, chest physiotherapy Identify severity clusters using biomarkers, to stratify follow-up and hospitalisation [33] α-1 antitrypsin deficiency LABA, LAMA, ICS α-1 antitrypsin augmentation therapy [17] Subgroups requiring further study Biomass and pollutant COPD Removal of pollutant exposure Use of predictive machine-learning to target individuals at greatest risk of pollutant-induced emphysema [31] Premalignant COPD Smoking cessation…”

“…Takahashi et al present an observational study exploring the relationship between hippocampal volume and clinical outcomes in patients with COPD [ 21 ]. Frail stable-state COPD patients and those reporting poor QoL were identified to have smaller estimated hippocampal volume via magnetic resonance imaging.…”

Gender Difference in the Relationship between Extrapulmonary Factors and Reduced Lung Function in Early Adulthood

“…For example, it has been reported that reduced lung function in early adulthood is associated with heart failure, arrhythmia, stroke, COPD, and obesity in the future [ 2 , 3 , 4 , 5 ]. Among them, COPD prevalence has been growing worldwide, an COPD can lead to physical inactivity, frailty, cognition issues, and mortality [ 6 , 7 , 8 , 9 ]. In addition to therapeutic drugs, approaches tailored to the characteristics of comorbidities, such as bronchiectasis, asthma, heart failure, sleep apnea, malnutrition, and frailty, have been shown to be viable in the management of COPD [ 10 ].…”