Impact of gasocrine signaling

Anbalagan, Savani

doi:10.31219/osf.io/nwby2

Cited by 2 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has the potential to unite researchers in recognizing the importance of vertebrate animal model organisms whose gasocrine signaling is also influenced by diet, environment and non-host factors. [28][29][30][31][32][33][34][35][36] Finally, I propose a modification of the definition of 'gasocrine signaling' from 'a cell signaling event based on the binding of gaseous signaling molecules or gasotransmitters to gasoreceptor proteins' to 'a cell signaling event based on the interaction of gaseous signaling molecules or gasotransmitters to gasoreceptor proteins'. Accepting E. coli SoxR as a gasoreceptor will enable us to explore other transcription factor-based gasoreceptor proteins in the cells of almost all other organisms.…”

Section: Introductionmentioning

confidence: 99%

Redox state-dependent gasocrine signaling

Anbalagan

2024

Preprint

View full text Add to dashboard Cite

I recently proposed the term 'gasocrine signaling' to describe a cell signaling event based on the binding of gaseous signaling molecules or gasotransmitters to gasoreceptor proteins. To investigate gasocrine signaling, it is essential to identify all the gasoreceptors for the gases generated in a cell or that reach a cell. Proteins can undergo gas-dependent changes in redox states, regulating protein disulfide bond formation or cleavage. Protein disulfide bonds play a pivotal role in protein folding, stability, localization, cellular signaling, function and the evolution of life. Drawing an analogy with the wicket rule of Cricket, where a batsman is dismissed upon bail dislodgement, I propose that the redox states of proteins with signaling or transcriptional activities, dependent on gaseous signaling molecules or gasotransmitters, be termed simply as 'gasoreceptor activation states’. I propose E. coli SoxR is a gasoreceptor with transcriptional activities, while mammalian VEGFR2 kinase and CD36 fatty acid transporter represent other classes of gasoreceptors. Embracing the complexity and diversity of gasoreceptors will facilitate a systematic exploration of the almost infinite number of gasoreceptors and their role in gasocrine signaling. Finally, I propose a modification of the definition of 'gasocrine signaling' to ‘a cell signaling event based on the interaction of gaseous signaling molecules or gasotransmitters to gasoreceptor proteins’.

show abstract

Section: Introductionmentioning

confidence: 99%

Redox state-dependent gasocrine signaling

Anbalagan

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…47 Investigating the identity and role of gasoreceptors in gasocrine signaling will open up the field of gasocrinology, which encompasses not only gasocrine interactions within organisms but also between different organisms and/or man‐made machine‐derived gases. 48 , 49 It may also allow us to better understand the fundamental mechanisms and general principles underlying disease ontogeny, animal behavior, and to develop better drugs, or to better understand the reasons why drugs fail in clinical trials, or why cells would require environment‐derived metal ions to sense gases, or if there are gases that can be sensed without the need for metal ions. Additionally, it could help us appreciate the need for animal model‐based curiosity‐driven basic science research to understand the role of gasocrine signaling in development, behavior, and disease ontology.…”

mentioning

confidence: 99%

Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors

Anbalagan

2024

Anim Models and Exp Med

Self Cite

View full text Add to dashboard Cite

The current restrictive criteria for gasotransmitters exclude oxygen (O2) as a gasotransmitter in vertebrates. In this manuscript, I propose a revision of gasotransmitter criteria to include O2 per se as a signaling molecule and 'essential gasotransmitter' for vertebrates. This revision would enable us to search for protein‐based O2‐binding sensors (gasoreceptors) in all cells in the brain or other tissues rather than specialized tissues such as the carotid body or gills. If microorganisms have protein‐based O2‐binding sensors or gasoreceptors such as DosP or FixL or FNR with diverse signaling domains, then eukaryotic cells must also have O2‐binding sensors or gasoreceptors. Just as there are protein‐based receptor(s) for nitric oxide (GUCY1A, GUCY1B, CLOCK, NR1D2) in cells of diverse tissues, it is reasonable to consider that there are protein‐based receptors for O2 in cells of diverse tissues as well. In mammals, O2 must be acting as a gasotransmitter or gaseous signaling molecule via protein‐based gasoreceptors such as androglobin that very likely mediate acute sensing of O2. Accepting O2 as an essential gasotransmitter will enable us to search for gasoreceptors not only for O2 but also for other nonessential gasotransmitters such as hydrogen sulfide, ammonia, methane, and ethylene. It will also allow us to investigate the role of environment‐derived metal ions in acute gas (or solute) sensing within and between organisms. Finally, accepting O2 per se as a signaling molecule acting via gasoreceptors will open up the field of gasocrinology.

show abstract

Impact of gasocrine signaling

Abstract: The impact of gasocrine signaling towards human survival is currently unclear. I will highlight a few examples of gasocrine and endogasocrine signaling and how it affects human survival and the economy.

Cited by 2 publications

References 40 publications

Redox state-dependent gasocrine signaling

Redox state-dependent gasocrine signaling

Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors

Contact Info

Product

Resources

About