Impact of Gate 99mTc DTPA GFR, Serum Creatinine and Urea in Diagnosis of Patients with Chronic Kidney Failure

Miftari, Rame; Adem, Nura; Topçiu-Shufta, Valdete; Miftari, Valon; Murseli, Arbenita; Haxhibeqiri, Valdete

doi:10.5455/aim.2017.25.99-102

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Camera-based imaging of GFR is, however, currently limited to 99m Tc-diethylenetriaminepentaacetic acid (DTPA) single photon emission computed tomography (SPECT) 14 . The specificity and sensitivity of camera-based GFR as diagnostic for renal failure was 100% and 47.5% for 99m Tc-DTPA, respectively 20 . 99m Tc-mercaptoazyltriglycerine (MAG3) is another SPECT-based method for imaging-based urography that is primarily cleared by tubular secretion, and is often used to evaluate renal plasma flow 14 .…”

Section: Introductionmentioning

confidence: 95%

Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent

et al. 2023

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Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of kidney function, with clinical estimates providing a global assessment of kidney health without spatial information of kidney- or region-specific dysfunction. The addition of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to the anatomical imaging already performed would yield a ‘one-stop-shop’ for renal assessment in cases of suspected AKI and CKD. Towards urography by DCE-MRI, we evaluated a class of nitrogen-centered organic radicals known as verdazyls, which are extremely stable even in highly reducing environments. A glucose-modified verdazyl, glucoverdazyl, provided contrast limited to kidney and bladder, affording functional kidney evaluation in mouse models of unilateral ureteral obstruction (UUO) and folic acid-induced nephropathy (FAN). Imaging outcomes correlated with histology and hematology assessing kidney dysfunction, and glucoverdazyl clearance rates were found to be a reliable surrogate measure of GFR.

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Section: Introductionmentioning

confidence: 95%

Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent

et al. 2023

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“…Researchers have confirmed this finding (10) . A recent study suggests that renal scintigraphy combined with biochemical tests is a useful method for early detection of chronic renal failure in patients (11) .…”

Section: Introductionmentioning

confidence: 99%

Correlation and concordance of glomerular filtration rate from renal scintigraphy and modified modification of diet in renal disease equation

Hsu

Chang

2022

Int J Radiat Res

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Background:The aim of this study is to find the correlation of the glomerular filtration rate (GFR) measured using Gate's method and modified Modification of Diet in Renal Disease (mMDRD) equation. Materials and Methods: Patients who received Tc-99 DTPA renal scintigraphy were enrolled in the study. The GFR obtained from Gate's method via renal scintigraphy and mMDRD equation from plasma creatinine were recorded. A comparison and correlation between the GFRs based on different time intervals was analyzed. Results: Sixty patients were enrolled in this study. They were divided into four groups based on different time intervals between radionuclide renal scintigraphy and plasma creatinine test. Group 1, 2, 3, and 4 consisted of patients whose plasma creatinine tests checked within ± 3 days, ± 4-7 days, ± 8-14 days, and ± 15-31 days from renal scintigraphy, respectively. Correlation coefficient of group 1, 2, 3, and 4 showed 0.87 (p < 0.001), 0.79 (p = 0.007), 0.67 (p = 0.009), and 0.58 (p = 0.012), respectively. Conclusion: Significant correlations were noticed in the GFR calculated from Gate's method and by mMDRD equation. It was found that the shorter the time interval between plasma creatinine test and radionuclide renal scintigraphy, the higher the correlation was.

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“…caused by chronic renal failure increased significantly from the 27th position in 1990 to 18th position in 2010 [1] . Currently, more than 2 million people worldwide receive treatment in form of dialysis or a kidney transplant to stay alive, representing only 10% of people who actually need treatment to live [2] .…”

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confidence: 96%

The Formulation of Minimal Clinically Important Differences in the Quality of Life Instrument for Patients with Chronic Renal Failure (QLICD-CRF) Based on Combinations of Anchor-Based and Distribution-Based Methods

Huang¹,

Yang²,

Wang³

et al. 2020

Preprint

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Background Chronic renal failure is global problem and represents a major cause of morbidity and mortality. Studies of quality of life in patients with chronic renal failure can be helpful to improve patient survival rates. The minimal clinical important difference (MCID) is a score that reflects the effect of patient treatment or nursing care. Doctors or researchers use this factor to assess the validity of results, and this information reflects the combined importance of the patient's opinion and the doctor's explanation.Methods Patients diagnosed with chronic renal failure and able to read and understand the questionnaires at the First Affiliated Hospital of Kunming Medical University were included in this study and completed the questionnaires independently. Using the anchor-based method and the distribution-based method, the MCIDs of the QLICD-CRF were calculated based on the data from 164 valid questionnaires at the time of admission and 111 valid questionnaires at discharge. The medians of patients' quality of life scores calculated using the anchor-based method were referred to as MCIDs based on the anchor-based method, whereas the results calculated based on effect size (ES), standard error of measurement (SEM) and reliable change index (RCI) were referred to as MCIDs based on the distribution-based method. Then, the final results were calculated according to the weight of the calculation obtained using several methods. Results MCIDs of the physical domain (PHD), psychological domain (PSD), social domain (SOD), core/general domain (CGD), specific domain (SPD) and the total score (TOT) of the QLICD-CRF were 10, 9, 8, 7, 8 and 7, respectively. Conclusion Calculations of MCIDs of QLICD-CRF scores could compensate for insufficient P-values; thus, the interpretation of the outcomes in quality of life studies could be more objective and specific.

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Impact of Gate 99mTc DTPA GFR, Serum Creatinine and Urea in Diagnosis of Patients with Chronic Kidney Failure

Cited by 5 publications

References 10 publications

Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent

Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent

Correlation and concordance of glomerular filtration rate from renal scintigraphy and modified modification of diet in renal disease equation

The Formulation of Minimal Clinically Important Differences in the Quality of Life Instrument for Patients with Chronic Renal Failure (QLICD-CRF) Based on Combinations of Anchor-Based and Distribution-Based Methods

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