Impact of gender on corticotropin‐releasing factor and noradrenergic sensitivity in cocaine use disorder

McRae‐Clark, Aimee L.; Cason, Angie M.; Kohtz, Amy S.; Santa-Maria, Megan Moran; Aston‐Jones, Gary; Brady, Kathleen T.

doi:10.1002/jnr.23860

Cited by 13 publications

(7 citation statements)

References 85 publications

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“…HR elevations occur immediately after exposure to a stressor and are regulated the locus-coeruleus-noradrenergic (LC-NE) sympathetic nervous system, which is rapidly mobilized following stress. There is a robust literature suggesting increased sensitivity of the noradrenergic system in women with cocaine (McRae-Clark et al, 2017) and tobacco (McKee et al, 2015) use disorders as compared to men. For example, women with cocaine use disorder exhibit more physiologic response and anxiety when administered yohimbine, an agent that increases NE release (Moran-Santa Maria et al, 2014) and more diminution of craving and stress response following administration of an agent that decreases noradrenergic function (Fox et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study

Gilmore

Guille

Baker

et al. 2019

Addictive Behaviors

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Background-Opioid dependence is a significant public health problem in the United States and the number of opioid overdose deaths among women has increased dramatically in comparison to men in the last few years. In this context, understanding the biological mechanisms underlying gender differences in vulnerability to opioid dependence is essential. Methods-The current pilot study examined gender differences in subjective stress, heart rate (HR), and cortisol/ dephydroepiandrosterone (DHEA) response to a laboratory stressor (Trier Social Stress Test; TSST) or a no-stress condition, and drug cue paradigm among men (n=21) and women (n=18) with opioid dependence.

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Section: Discussionmentioning

confidence: 99%

Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study

Gilmore

Guille

Baker

et al. 2019

Addictive Behaviors

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“…Despite the previously documented exaggerated response to spinal anaesthesia in females, [19][20][21][22] the effectiveness of NE infusion for maintaining blood pressure with associated greater heart rate and cardiac output than with phenylephrine during SA for Caesarean section, as documented in the literature, [23][24][25] could be considered as support for the results of the current study.…”

Section: Discussionmentioning

confidence: 68%

Nor-epinephrine versus vasopressin infusion for prevention of spinal-induced hypotension: a placebo-controlled study

Mohamed

Safan

2017

Southern African Journal of Anaesthesia and Analgesia

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Objectives:To evaluate the prophylactic effect of norepinephrine (NE) and vasopressin (VP) infusion on frequency and severity of spinal anaesthesia-induced hypotension (SAIH). Patients and methods: A total of 240 young male patients were randomly allocated into three equal groups: Group C received plain saline infusion, Group NE received NE infusion (0.1 mg/ml; 3 ml/h) and Group VP received VP infusion (0.5 U/ml; 1 U/h); all infusions started synchronously with spinal injection (SI). Systolic arterial pressure (SAP) and heart rate (HR) measures were determined at 1, 4, 7 and 10-min; then every 5-min for 30 min. SAP reduction of >10% was treated by supplementary fluid therapy and resistant cases or patients who had SAP reduction of ≥20% received ephedrine (10 mg). Results: In comparison with baseline SAP, SAP was decreased by > 20% in eight control patients, by < 10% in 22 patients and in 50 control patients SAP decrease ranged between 10% and 20%. In the NE and VP groups, no patient had decreased SAP of > 10%, while 15 patients had increased SAP of > 10% and 145 patients showed no SAP change with significant difference between the two groups (p = 0.0003). Throughout the 30 min after spinal block, all SAP and HR measures of control patients were significantly (p = 0.001) lower compared with their baseline measures and with corresponding measures of patients of the NE and VP groups with non-significant difference between the two groups. Seven patients (8.8%) in the control group had nausea and three (3.8%) had nausea and vomiting, while no patient in the NE and VP groups had nausea or required anti-emetic therapy. Conclusion: Vasopressor infusion given synchronously with spinal injection is an appropriate prophylactic policy against SAIH. NE infusion did better than VP infusion and provided better haemodynamic stability after spinal injection. However, VP infusion allowed control of blood pressure despite the significant decrease till 7 min after SI.

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“…These are considered limitations, since gender differences in CRH reactivity have been demonstrated. 29,30 In these studies, women were shown to be more sensitive to stimulation than men. In the present study, 19 of 20 subjects were men.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals

Yamasaki

Tomita

Takimoto

et al. 2017

J Neurogastroenterol Motil

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Background/AimsWhen a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However, the influence of CRH on the esophagus is yet unknown. Accordingly, we investigated whether intravenous CRH administration increases esophageal sensitivity to electrical stimulation in healthy Japanese subjects. MethodsTwenty healthy subjects were recruited. We quantified the initial perception threshold (IPT) every 15 minutes after CRH injection. Venous blood was collected with a cannula, and both plasma adrenocorticotropic hormone (ACTH) and cortisol were measured at pre-stimulation, 0, 30, 60, 90, and 120 minutes. The results from each time point were compared against a baseline IPT obtained before electrical stimulation was initiated. ResultsWhen compared to the baseline IPT value (16.9 ± 4.5), CRH significantly decreased electrical threshold of the esophagus at 30, 45, 60, 75 minutes (14.1 ± 4.2, 13.1 ± 5.0, 12.1 ± 5.7, 14.0 ± 5.8 minutes, P < 0.01, respectively) after CRH injection, suggesting that CRH increased esophageal sensitivity to the electrical stimulus. CRH also significantly increased plasma ACTH levels at 30 minutes (50.3 ± 17.7, P < 0.01), and cortisol levels at 30 minutes (22.0 ± 6.7 minutes, P < 0.01) and 60 minutes (20.3 ± 6.7 minutes, P < 0.01) after CRH injection, when compared to the pre-stimulation ACTH and cortisol values. ConclusionIntravenous CRH administration increased esophageal electrical sensitivity in normal subjects, emphasizing the important role of stress in esophageal sensitivity.

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Impact of gender on corticotropin‐releasing factor and noradrenergic sensitivity in cocaine use disorder

Cited by 13 publications

References 85 publications

Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study

Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study

Nor-epinephrine versus vasopressin infusion for prevention of spinal-induced hypotension: a placebo-controlled study

Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals

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