Impact of gender on the association between marital status and head and neck cancer outcomes

Simpson, Matthew C.; Challapalli, Sai D; Cass, Lauren M.; Zahirsha, Zisansha

doi:10.1016/j.oraloncology.2018.12.009

Cited by 26 publications

(32 citation statements)

References 31 publications

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“…The importance of partnership status as a determinant of the level of health of the general population and of survival outcomes has been documented in many gynecological malignancies, including uterine, cervical, and ovarian cancers16–18 as well as non-gynecologic malignancies 13 19–22. However, this is the first study to address the association between partnership status and stage at presentation for vulvar squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 94%

Impact of partnership status on clinical outcomes of patients with vulvar squamous cell carcinoma and performance of sentinel lymph node biopsy

Alhatem

Lambert

Karanfilian

et al. 2020

Int J Gynecol Cancer

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ObjectivesVulvar squamous cell carcinoma is a rare malignancy and lymph node involvement is the most significant prognostic factor. We aimed to evaluate the association between partnership status and mortality from vulvar squamous cell carcinoma, cancer stage at the time of presentation, and the decision for sentinel lymph node biopsy.MethodsThe US National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database was queried and different parameters were evaluated relative to partnership status. A total of 4851 patients with vulvar squamous cell carcinoma, >18 years of age, who presented between January 2010 to December 2015, were analyzed. Kaplan-Meier and Cox regression analyses were used to assess survival and hazard ratio. Multinomial regression analysis and χ2 were utilized to evaluate odd ratios and significance of variables.ResultsMost patients were unpartnered (58.5%), including never married (17.7%), divorced (13.8%), or widowed (27%). Partnered patients were mostly Caucasian (88.4%), insured (74%), and presented with stage I disease (57.2%), compared with unpartnered patients (79.1%), (61.7%), and (51.7%), respectively (p<0.01). The mean survival time (months) in partnered patients was longer, compared with unpartnered (p<0.001), and the difference between both groups increased from 9 months at stage I to 24 months at stage IV, which remained independently significant after adjusting the different variables. Cox regression showed that partnered patients had a lower hazard ratio than unpartnered patients (p<0.01). Mortality from vulvar squamous cell carcinoma increased with age at diagnosis, no surgery, and unemployment (p<0.01). Unpartnered patients were the least likely to undergo sentinel lymph node biopsy in early stages, compared with partnered (p<0.01). Univariate Cox regression analysis showed that not performing sentinel lymph node biopsy almost doubled the hazard ratio of vulvar squamous cell carcinoma (p<0.01).ConclusionsPartnership status should be considered when counseling patients for vulvar squamous cell carcinoma therapy and when recommending screening and follow-up to optimize patient care.

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Section: Discussionmentioning

confidence: 94%

Impact of partnership status on clinical outcomes of patients with vulvar squamous cell carcinoma and performance of sentinel lymph node biopsy

Alhatem

Lambert

Karanfilian

et al. 2020

Int J Gynecol Cancer

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“…Lastly, psychosocial factors including social support may affect cancer survival. For example, the survival advantage of having a partner for cancer patients is well known and a married male could benefit more than females [27,28]. The need for social support was shown to be inversely associated with income level among Korean cancer patients [29].…”

Section: Discussionmentioning

confidence: 99%

Occupational Class and Cancer Survival in Korean Men: Follow-Up Study of Nation-Wide Working Population

Lee

Zaitsu

Kim

et al. 2020

IJERPH

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Background: We aimed to describe inequalities in site-specific cancer survival across different occupational classes in Korean men. Methods: Subjects included cancer diagnosed members of the national employment insurance program during 1995–2008. A total of 134,384 male cases were followed by linking their data to the Death registry until 2009. Occupational classes were categorized according to the Korean Standard Occupational Classification (KSOC). Hazard ratio adjusting age and diagnosed year were calculated for each occupation by cancer sites. Results: Men in service/sales and blue-collar occupations had lower survival of all cancer sites combined and esophagus, stomach, colorectal, liver, larynx, lung, prostate, thyroid cancer and non-Hodgkin’s lymphoma than men in professional and managerial positions. Cancer sites with good prognosis like prostate cancer showed wider gap across occupational class. Conclusions: Considerable inequalities in cancer survival were found by occupation among Korean men. Cancer control policy should more focus on lower socioeconomic occupational class.

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“…Furthermore, we did not have data describing quality of marital satisfaction, or differences in survival benefits of marriage based on gender. It has been reported that the level of marital satisfaction might significantly impact quality of life of HNC survivors (Jenewein et al, 2008), and that male HNC survivors might benefit from being married more than female HNC survivors (Simpson et al, 2019). Finally, it is important to stress that being married does not replace the need for other forms of social and emotional support for cancer survivors (Osazuwa-Peters, Arnold, Loux, Varvares, & Schootman, 2018).…”

Section: Discussionmentioning

confidence: 99%

What's Love Got to do with it? Marital status and survival of head and neck cancer

et al. 2019

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Objective To determine whether marital status independently predicts survival in a head and neck cancer (HNC) survivor population. Methods In this retrospective cohort study, we analysed data from 460 adult patients (59.31 ± 11.42) years diagnosed with HNC at an academic tertiary referral centre between 1997 and 2012. Cox proportional hazards model estimated the effect of marital status on survival. Results Our study had 73% men, and 82.2% were Whites. We found an association between marital status and HNC survival. Unmarried HNC patients had a 66% increase in hazard of death compared to married patients (aHR = 1.66, 95% CI = 1.23–2.23). This was after controlling for sociodemographic variables (age, race, sex and health insurance status), social habits (tobacco and alcohol), primary anatomical subsite (oral cavity, oropharyngeal, laryngeal and others), stage at presentation (early vs. late stage) and treatment modality (surgery, surgery with adjuvant therapies, other single modality therapy and palliative care). Conclusions Being married confers survival advantage for HNC survivors. Our finding underscores the need to recognise this aspect of survivorship. Social support should be considered part of standard care for managing HNC. There may also be need to develop other support mechanisms, especially for unmarried HNC survivors.

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Impact of gender on the association between marital status and head and neck cancer outcomes

Cited by 26 publications

References 31 publications

Impact of partnership status on clinical outcomes of patients with vulvar squamous cell carcinoma and performance of sentinel lymph node biopsy

Impact of partnership status on clinical outcomes of patients with vulvar squamous cell carcinoma and performance of sentinel lymph node biopsy

Occupational Class and Cancer Survival in Korean Men: Follow-Up Study of Nation-Wide Working Population

What's Love Got to do with it? Marital status and survival of head and neck cancer

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