Impact of generic antimalarial or Phyllanthus amarus and vitamin co-administration on antioxidant status of experimental mice infested with Plasmodium berghei

Ojezele, Matthew Obaineh; Moke, Emuesiri Goodies; Onyesom, I

doi:10.1016/j.bjbas.2017.04.008

Cited by 14 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highest antioxidant activity was shown by Phyllanthus seed extracts alone or in combination with vitamins (A, B, E) in P. berghei (NK 65 strain) infected mice. The combined activity of artesunate/vitamins also showed an enhanced antimalarial activity due to their antioxidant activity, while combination with vitamin C was counterproductive [ 45 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Nisar

Ahmed

et al. 2018

Molecules

View full text Add to dashboard Cite

Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. Phyllanthus is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases (constipation, inhalation related, arthritis, loss of appetite, injuries, conjunctivitis, diarrhoea, running nose, common cold, malaria, blennorrhagia, colic, diabetes mellitus, dysentery, indigestion, fever, gout, gonorrheal diseases of males and females, skin itching, jaundice, hepatic disorders, leucorrhea, vaginitis, menstrual irregularities, obesity, stomach pains, and tumors), confectionaries, food industry, and in some pesticides. Phyllanthus species are rich in diversity of phytochemicals e.g., tannins, terpenes, alkaloids, glycosidic compounds, saponins, and flavones etc. More in depth studies are a direly needed to identify more compounds with specific cellular functions to treat various ailments.

show abstract

Section: Biological Activitiesmentioning

confidence: 99%

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Nisar

Ahmed

et al. 2018

Molecules

View full text Add to dashboard Cite

show abstract

“…Increase in the antioxidants levels may be due to successful antimalarial activity of the drug alone which may have further enhanced the ameliorative effect in scavenging all the free radicals (ROS) produced by the parasite, drug action and the natural immune response of the host (mice) [29]. In addition, the deficiency of glutathione reductase enzymes leads to increase production of free radicals such as H 2 O 2 , superoxide which are major oxidants in oxidative stress [30].…”

Section: Discussionmentioning

confidence: 99%

Potential Role of Red Palm Oil Supplemented Diet on Oxidative Stress Enzymes inPlasmodium BergheiInduced Malaria

Adeleke¹,

Adejumobi

Akinola

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundMalaria parasites are very vulnerable to oxidative stress during the part of their life cycle when they inhabit the erythrocytes. Studies have shown that dietary intake of antioxidant plays a role in stabilizing oxidative stress.MethodsThe objective of this research work was to examine the antioxidative effect of red palm oil on Plasmodium berghei malaria induced oxidative stress. Sixty (60) mice were distributed into five groups. Group A served as the negative control (healthy mice with normal feed); group B as positive control (healthy mice fed with red palm oil without malaria parasite.while the other groups (C to E) served as the test groups. Group C served as group of healthy mice fed with red palm oil (pelletized), infected with malaria parasite without antimalaria drug. Group D served as group of healthy mice fed with red palm oil (pelletized), infected with malaria parasite and treated with amodiaquine. Group E served as group of healthy mice fed with normal feed, infected with malaria parasite and treated with amodiaquine. The parasitemia levels were estimated on days 1,4 and 5. The activity of oxidative stress enzymes biomarkers were determined spectrophotometrically.ResultGroup A showed a statistically significant increase in the activity of SOD (1.90 ± 0.16 units/mg protein), GST (1.68 ± 0.086 units/L) compared to group C, SOD (3.54 ± 0.83 units/mg protein), GST (2.12 ± 0.20 units/L). Group B showed a statistical significant decrease in the activities of SOD (3.22 ± 0.33 units/mg protein), Catalase (49.11 ± 2.35 µmol/min), GSH-R (31.50 ± 2.48 units/L) compared to group E, SOD (2.18 ± 0.39 units/mg protein), Catalase (44.07 ± 3.88 µmol/min), GSH-R (27.75 ± 1.64 units/L).ConclusionThe dietary intake of red palm oil helps to reduce free radical mediated injury to the tissue thus preventing oxidative stress induced by malaria or any other factors.

show abstract

“…The antioxidant activity of Phyllanthus amarus was observed in malarious albino rats with serum increase of antioxidants such as glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase and decrease of malonic aldehyde. The serum increase of malonic aldehyde is a manifestation of the oxidative stress observed in the pathogenesis of parasitic diseases (Ojezele et al, 2017). The pathogenesis of coccidiosis is associated with oxidative stress caused by increased production of Reactive Oxygen Species due to parasite activities as well as the immune response of the host organism causing depletion of antioxidants enzyme levels, such as glutathione, a potent redox and the increase of lipid peroxidation of enterocytes and cells surrounding the intestines (Gotep et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of Phyllanthus amarus, Jatropha curcas and Piliostigma thonningii on experimental chicken coccidiosis

Dakpogan¹,

Houndonougbo²,

Pomalegni³

et al. 2019

J.Anim.Plant Sci.

View full text Add to dashboard Cite

The anticoccidial activity of Phyllanthus amarus (Hurricane weed), Jatropha curcas (purging nut) and Piliostigma thonningii (monkey bread) was tested on seventy five Eimeria tenella infected Isa-brown male day-old chicks in a completely randomized design as an alternative measure of controlling coccidiosis. Each chick was orally challenged with 15 000 Eimeria tenella sporulated oocysts. There were five groups infected chicks. The first, second and third groups received , the decoction of Phyllanthus amarus, Jatropha curcas and Piliostigma thonningii, ad libitum respectively for five days post-inoculation as drinking beverage. The fourth group was treated with Amprolium orally for also five days post-infection and the fifth group was the infected untreated control. Body weight gain, feed conversion ratio, lesion score, proportion of bloody droppings, survivability, morbidity and oocyst excretion were evaluated. The results showed an efficacy of Phyllanthus amarus in the reduction of oocyst excretion with a reduction rate of 87% compared with the infected untreated control group oocyst excretion. Moreover, macroscopic lesion intensity reduction and low presence of bloody diarrhoea were observed with the Phyllanthus amarus treated chicks. The oocyst excretion reduction rate was 74% with Jatropha curcas infected treated chicks. The growth performance results were similar among the infected treated chick groups. Piliostigma thonningii was less effective in reducing oocyst excretion compared with the other two medicinal plants. Further spectroscopic studies are needed to value the active anticoccidial ingredients in these plants.

show abstract

Impact of generic antimalarial or Phyllanthus amarus and vitamin co-administration on antioxidant status of experimental mice infested with Plasmodium berghei

Cited by 14 publications

References 16 publications

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature

Potential Role of Red Palm Oil Supplemented Diet on Oxidative Stress Enzymes inPlasmodium BergheiInduced Malaria

Evaluation of the effect of Phyllanthus amarus, Jatropha curcas and Piliostigma thonningii on experimental chicken coccidiosis

Contact Info

Product

Resources

About