Impact of genetic status on the survival outcomes of patients with clinical stage I non-small cell lung cancer with a radiological pure-solid appearance

Sun, Ke; Li, Meiling; Shang, Mingdong; Su, Xiaolian; Zhao, Jianya; Wang, Bin; Wu, Chunyan; Zhang, Lei; Yang, Shan; Sun, Xuejun

doi:10.1016/j.lungcan.2022.02.005

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…An additional observation was the absence of discernible variance in recurrence rate based on pathological subtype or the presence of driver-gene mutations. As the authors point out, this finding contradicts previously published studies ( 12 , 13 ), however, this may be attributed to their relatively low rates of recurrence overall. A final, crucial point of the study, as well as JCOG0802 and CALBG140503, is the importance of implementing meticulous surgical technique in oncologic resections.…”

contrasting

confidence: 82%

Wedge resection—finding its place in early-stage non-small cell lung cancer?

Hill¹,

Gibney²

2023

J Thorac Dis

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contrasting

confidence: 82%

Wedge resection—finding its place in early-stage non-small cell lung cancer?

Hill¹,

Gibney²

2023

J Thorac Dis

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“…It is worth point out that, from a previous study, pathological subtypes ( 27 ) and the status of drive-gene mutations ( 28 ) may influence the recurrence of early-stage LUAD postoperatively. However, a significant difference in the distribution of these 2 factors between recurrence and non-recurrence patients was not observed in our study, which demonstrated that the status of drive gene mutations and the component of MPA/SPA did not affect recurrence in wedge-treated patients with IA-LUAD postoperatively.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of wedge resection for peripheral stage IA lung adenocarcinoma: a real-world study based on a single center

Bian¹,

Xiong²,

Jin³

et al. 2023

J Thorac Dis

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Background: The effectiveness of segmentectomy for stage IA lung adenocarcinoma (IA-LUAD) has been well-documented. However, the efficacy and safety of wedge resection for peripheral IA-LUAD remains controversial. This study evaluated the feasibility of wedge resection in patients with peripheral IA-LUAD.Methods: Patients with peripheral IA-LUAD who underwent wedge resection by video-assisted thoracoscopic surgery (VATS) at Shanghai Pulmonary Hospital were reviewed. Cox proportional hazards modeling was performed to identify predictors of recurrence. Receiver operating characteristic (ROC) curve analysis was used to calculate the optimal cutoffs of identified predictors.Results: A total of 186 patients (female/male, 115/71; mean age, 59.9 years) were included. Mean maximum dimension of consolidation component (MCD) was 5.6 mm, consolidation-to-tumor ratio (CTR) was 37%, and mean CT value of tumor (CTVt) was −285.4 HU. With a median follow-up of 67 months (interquartile range, 52-72 months), the 5-year recurrence rate was 4.84%. Ten patients occurred recurrence postoperatively. No recurrence was observed adjacent to the surgical margin. Increasing MCD, CTR, and CTVt were associated with a higher risk of recurrence, with corresponding hazard ratios (HRs) of 1.212 [95% confidence interval (

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Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer

Mu,

Huang,

et al. 2023

Precision Clinical Medicine

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A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography. But pure solid T1 lung cancer with ≤3 cm in the greatest dimension is not always at an early stage, despite its small size. This type of cancer can be highly aggressive and is associated with pathological involvement, metastasis, postoperative relapse, and even death. However, it is easily misdiagnosed or delay diagnosed in clinics and thus poses a serious threat to human health. The percentage of nodal or extrathoracic metastases has been reported to be >20% in T1 lung cancer. As such, understanding and identifying the aggressive characteristics of pure solid T1 lung cancer is crucial for prevention, diagnosis, and therapeutic strategies, and beneficial to improving the prognosis. With the widespread of lung cancer screening, these highly invasive pure solid T1 lung cancer will become the main advanced lung cancer in future. However, there is limited information regarding precision medicine on how to identify these “early-stage” aggressive lung cancers. To provide clinicians with new insights into early recognition and intervention of the highly invasive pure solid T1 lung cancer, this review summarizes its clinical characteristics, imaging, pathology, gene alterations, immune microenvironment, multi-omics, and current techniques for diagnosis and prediction.

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Impact of genetic status on the survival outcomes of patients with clinical stage I non-small cell lung cancer with a radiological pure-solid appearance

Cited by 4 publications

References 27 publications

Wedge resection—finding its place in early-stage non-small cell lung cancer?

Wedge resection—finding its place in early-stage non-small cell lung cancer?

The efficacy and safety of wedge resection for peripheral stage IA lung adenocarcinoma: a real-world study based on a single center

Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer

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