Impact of genetic variants of IL-6, IL6R, LRP5, ESR1 and SP7 genes on bone mineral density in postmenopausal Mexican-Mestizo women with obesity

Méndez, Juan Pablo; Rojano-Mejía, David; Coral‐Vázquez, Ramón Mauricio; Coronel, Agustín; Galindo, Javier Leonardo; Casas, María José; Soriano, Ruth; García-García, Eduardo; Vilchis, Felipe; Canto, Patricia

doi:10.1016/j.gene.2013.07.008

Cited by 22 publications

(11 citation statements)

References 37 publications

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“…As well as research of Hubungan [20] showed that low BMI and decreased bone strength associated with reduced bone mass in all parts of the body. Study of Mendez et al showed relationship of BMI and BMD was significantly positive at the lumbar spine, pelvis and femoral neck [21].…”

Section: Discussionmentioning

confidence: 93%

The Correlation of Bone Mineral Density (BMD), Body Mass Index (BMI) and Osteocalcin in Postmenopausal Women

Hendrijantini¹,

Alie²,

Setiawati³

et al. 2016

Biol Med (Aligarh)

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Background: Osteoporosis is related to the decrease of bone density, osteoporosis requires attention from dentists because it can also occurs in the jaw bone. Osteoporosis is calculated with a quantitative assessment of bone density, which is called Bone Mineral Density (BMD). The best imaging modalities to assess bone density are the Dual Energy examination methods X-ray Absorptiometry (DEXA). In addition to DEXA, osteoporosis examination can be performed with measurement of Body Mass Index (BMI), which is a ratio of weight and height. Process of bone formation by osteoblasts can be examined by bone marker such as Osteocalcin, as a parameter (alone or in combination with BMD) to determine metabolic bone disorders during bone formation and bone remodeling (bone turnover).

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Section: Discussionmentioning

confidence: 93%

The Correlation of Bone Mineral Density (BMD), Body Mass Index (BMI) and Osteocalcin in Postmenopausal Women

Hendrijantini¹,

Alie²,

Setiawati³

et al. 2016

Biol Med (Aligarh)

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“…PMOP, an important health problem among postmenopausal women, is such a common skeletal disease characterized by skeletal fragility resulting in fractures from relatively minor trauma that several risk factors 22 – 26 may play an important role in the etiology and progression. Recently, PMOP is considered as an immune disease due to the fact that several cytokines and immune factors 8 , 10 have been observed in the etiology of PMOP, such as TGF-β, 17 , 18 IL-6, 27 , IL-10, 17 , IL-17, 26 , etc. Among these genetic factors, TGF-β1 that plays an important role in the regulation of both bone formation and resorption, tissue recycling, and immune response has been widely studied in both Asian and Caucasian patients.…”

Section: Discussionmentioning

confidence: 99%

The Transforming Growth Factor-β1 (TGF-β1) Gene Polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and Susceptibility to Postmenopausal Osteoporosis

Sun

Zhang

et al. 2015

Medicine

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The aim of the present study was to integrate all the eligible studies and investigate whether the transforming growth factor-β1 (TGF-β1) gene polymorphisms (TGF-β1 T869C and TGF-β1 T29C) are correlated with postmenopausal osteoporosis (PMOP) risk.PMOP is a common skeletal disease and several genetic factors play an important role in the development and progression of PMOP. Significant associations between TGF-β1 gene polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and PMOP risk have been reported; however, some of these results are controversial.A systematic online search was performed using PubMed, EMBASE, Web of Science, and the Cochrane Library to identify case–control studies investigating the relationship between TGF-β1 T869C and TGF-β1 T29C polymorphisms and the susceptibility of PMOP. The pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the associations, and subgroup meta-analyses were performed according to the ethnicity of the study populations.Eight studies involving 1851 cases and 2247 controls met the inclusion criteria after assessment by 2 reviewers. Overall, there were significant associations between TGF-β1 T869C and TGF-β1 T29C polymorphisms and PMOP (TGF-β1 T869C—C vs T: OR = 1.18, 95% CI = 1.02–1.36, P = 0.030; CC vs TT: OR = 1.38, 95% CI = 1.01–1.88, P = 0.042; CC vs CT/TT: OR = 1.39, 95% CI = 1.09–1.76, P = 0.008; TGF-β1 T29C—CT vs TT: OR = 1.25, 95% CI = 1.02–1.53, P = 0.032; CT/CC vs TT: OR = 1.37, 95% CI = 1.02–1.84, P = 0.035). In the subgroup analysis of ethnicity, significant association was observed between TGF-β1 T869C polymorphism and PMOP risk in Asian population (C vs T: OR = 1.18, 95% CI = 1.01–1.38, P = 0.043; CC vs TT: OR = 1.41, 95% CI = 1.01–1.97, P = 0.047; CT/CC vs TT: OR = 1.31, 95% CI = 1.03–1.66, P = 0.026; CC vs CT/TT: OR = 1.35, 95% CI = 1.03–1.75, P = 0.028); however, there was no significant association between TGF-β1 T869C polymorphism and PMOP risk in Caucasian population. With regard to TGF-β1 T29C polymorphism, significant association was also observed in Asian population (CT vs TT: OR = 1.37, 95% CI = 1.07–1.75, P = 0.013; CT/CC vs TT: OR = 1.54, 95% CI = 1.16–2.05, P = 0.003), while there was no significant association in Caucasian population.The TGF-β1 T869C and TGF-β1 T29C polymorphisms may be involved in susceptibility to PMOP, particular in Asian patients.

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“…Several genes bind to this region, including EZH2, YY1, TBP, ESR1, MAX, REST, USF1, SIN3AK20, ZNF143, SP2, CEBPB and SIN3A 36 . Among these genes, ESR1 and EZH2 have been implicated in bone maturation 11 37 38 . However, further study is required to explain the significance of these association signals.…”

Section: Discussionmentioning

confidence: 99%

“…An early twin study found that the heritability of bone mass was approximately 90% in the lumbar spine and 70% in the femoral neck 7 . Subsequent genetic association mapping studies, including a genome-wide association study (GWAS), identified several susceptibility genes that confer risk of OP and BMD 10 11 12 . Currently, more than 60 susceptible loci have been identified to be associated with BMD or OP 13 .…”

mentioning

confidence: 99%

Endochondral ossification pathway genes and postmenopausal osteoporosis: Association and specific allele related serum bone sialoprotein levels in Han Chinese

Zhang

Liu²,

Zhang

et al. 2015

Sci Rep

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Osteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and disrupted bone architecture, predisposing the patient to increased fracture risk. Evidence from early genetic epidemiological studies has indicated a major role for genetics in the development of osteoporosis and the variation in BMD. In this study, we focused on two key genes in the endochondral ossification pathway, IBSP and PTHLH. Over 9,000 postmenopausal Han Chinese women were recruited, and 54 SNPs were genotyped. Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels. Moreover, one haplotype (rs12425376-rs10843047-rs42294) covering the 5’ end of PTHLH was associated with postmenopausal osteoporosis. Our results provide evidence for the association of these two key endochondral ossification pathway genes with BMD and osteoporosis in postmenopausal Han Chinese women. Combined with previous findings, we provide evidence that a particular SNP in IBSP has an allele-specific effect on mRNA levels, which would, in turn, reflect serum IBSP levels.

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Impact of genetic variants of IL-6, IL6R, LRP5, ESR1 and SP7 genes on bone mineral density in postmenopausal Mexican-Mestizo women with obesity

Cited by 22 publications

References 37 publications

The Correlation of Bone Mineral Density (BMD), Body Mass Index (BMI) and Osteocalcin in Postmenopausal Women

The Correlation of Bone Mineral Density (BMD), Body Mass Index (BMI) and Osteocalcin in Postmenopausal Women

The Transforming Growth Factor-β1 (TGF-β1) Gene Polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and Susceptibility to Postmenopausal Osteoporosis

Endochondral ossification pathway genes and postmenopausal osteoporosis: Association and specific allele related serum bone sialoprotein levels in Han Chinese

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