Impact of genetics on third molar agenesis

Trakiniené, Giedrė; Šidlauskas, Antanas; Andriuškevičiūtė, Irena; Šalomskienė, Loreta; Švalkauskienė, Vilma; Smailienė, Dalia; Trakinis, Tomas

doi:10.1038/s41598-018-26740-7

Cited by 14 publications

(9 citation statements)

References 31 publications

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“…Indeed, this is also supported by the increased number of missing third molars in the agenesis sample compared to that expected by chance. A recent study analyzing data from 172 monozygotic and 112 dizygotic twins concluded that third molar formation is strongly controlled by additive genetic factors, providing further support to our statements (Trakinienė et al, 2018). This concept is in line with the evolutionary trend in humans towards less teeth, and more specifically, less molars (Kavanagh, Evans & Jernvall, 2007).…”

Section: Discussionsupporting

confidence: 87%

Third molar agenesis in modern humans with and without agenesis of other teeth

Scheiwiller¹,

Oeschger²,

Gkantidis³

2020

PeerJ

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Background The number of teeth in the human dentition is of interest both from developmental and evolutionary aspects. The present case-control study focused on the formation of third molars in modern humans aiming to shed more light on the most variable tooth class in the dentition. Materials and Methods For this reason, we investigated third molar formation in a sample of 303 individuals with agenesis of teeth other than third molars (agenesis group) and compared it to a sex and age matched control group of 303 individuals without agenesis of teeth other than third molars. Results The prevalence of third molar agenesis in the agenesis group was 50.8%, which is significantly higher than the 20.5% in the control group (p < 0.001). The chance of a missing third molar in the agenesis group was increased by 38.3% (p < 0.001), after controlling for the agenesis in other teeth factor. When considering the amount of missing third molars per individual, a clear tendency towards more missing third molars was evident in the agenesis group compared to the control group. The frequency of bilaterally missing third molars in the agenesis group was 29% in the maxilla, as well as in the mandible, which is about three times higher than the frequency of unilaterally missing third molars (p < 0.001). In the control group, bilaterally missing third molars occurred in 8.6% in the maxilla and 8.9% in the mandible. Conclusion The present results indicate that genetic factors involved in tooth agenesis affect also the dentition as a whole. Furthermore, the third molars are more vulnerable to factors involved in agenesis of other teeth and they are more often affected as a whole. These findings seem to be associated with the evolutionary trend in humans towards reduced molar number.

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Section: Discussionsupporting

confidence: 87%

Third molar agenesis in modern humans with and without agenesis of other teeth

Scheiwiller¹,

Oeschger²,

Gkantidis³

2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…Indeed, this is also supported by the increased number of missing third molars in the agenesis sample compared to that expected by chance. A recent study analysing data from 172 monozygotic and 112 dizygotic twins concluded that third molar formation is strongly controlled by additive genetic factors, providing further support to our statements (Trakinienė et al 2018). This concept is in line with the evolutionary trend in humans towards less teeth, and more specifically, less molars (Kavanagh et al 2007).…”

Section: Discussionsupporting

confidence: 85%

Peer Review #2 of "Third molar agenesis in modern humans with and without agenesis of other teeth (v0.2)"

2020

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Background. The number of teeth in the human dentition is of interest both from developmental and evolutionary aspects. The present case-control study focused on the formation of third molars in modern humans aiming to shed more light on the most variable tooth class in the dentition. Materials and Methods.For this reason, we investigated third molar formation in a sample of 303 individuals with agenesis of teeth other than third molars (agenesis group) and compared it to a sex and age matched control group of 303 individuals without agenesis of teeth other than third molars.Results. The prevalence of third molar agenesis in the agenesis group was 50.8%, which is significantly higher than the 20.5% in the control group (p < 0.001). The chance of a missing third molar in the agenesis group was increased by 38.3% (p < 0.001), after controlling for the agenesis in other teeth factor. When considering the amount of missing third molars per individual, a clear tendency towards more missing third molars was evident in the agenesis group compared to the control group. The frequency of bilaterally missing third molars in the agenesis group was 29% in the maxilla, as well as in the mandible, which is about three times higher than the frequency of unilaterally missing third molars (p < 0.001). In the control group, bilaterally missing third molars occurred in 8.6% in the maxilla and 8.9% in the mandible. Conclusion.The present results indicate that genetic factors involved in tooth agenesis affect also the dentition as a whole. Furthermore, the third molars are more vulnerable to factors involved in agenesis of other teeth and they are more often affected as a whole. These findings seem to be associated with the evolutionary trend in humans towards reduced molar number.

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“…Carabelli's trait, along with certain molar variants, received much attention (Alvesalo et al, ; Berry, ; Biggerstaff, , ; Kaul, Sharma, Sharma, & Corruccini, ; Laatikainen & Ranta, ; Mizoguchi, ; Scott & Potter, ; Sofaer, MacLean, & Bailit, ). More recently, sophisticated model‐fitting approaches have become the norm, such as path analysis and structural equation modeling (Hughes, Vo, Mihailidis, & Townsend, ; Townsend & Martin, ; Townsend et al, ; Trakinienė et al, ), as well as variance components analysis via maximum likelihood estimation (Paul, Stojanowski, Hughes, Brook, & Townsend, ; Stojanowski et al, ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative genetic analyses of postcanine morphological crown variation

Stojanowski

Paul

Seidel

et al. 2019

American J Phys Anthropol

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Objectives: This article presents estimates of narrow-sense heritability and bivariate genetic correlation for 14 tooth crown morphological variants scored on permanent premolars, first molars, and second molars. The objective is to inform data collection and analytical practices in dental biodistance and to provide insights on the development of molar crowns as integrated structures.Materials and Methods: African American dental casts from the Menegaz-Bock collection were recorded for the Arizona State University Dental Anthropology System. Estimates of narrowsense heritability and genetic correlation were generated using SOLAR v.8.1.1, which included assessment of age, sex, and birth year as covariates. Both continuous scale and dichotomized estimates are provided.Results: Heritability estimates were nonsignificant for the majority of variables; however, for variables yielding significant estimates, values were moderate to high in magnitude and comparable to previous studies. Comparing left and right-side heritability estimates suggests directional asymmetry in the expression of environmental variance, something not seen in anterior tooth traits. Genetic correlations were moderate among antimeres and metameres and low for different traits scored on the same tooth crown. Although several negative correlations were noted, few reached statistical significance. Results affirm some of the current data cleaning and analytical practices in dental biodistance, but others are called into question. These include the pooling of males and females and combining left and right-side data into a single dataset.Conclusions: In comparison to anterior tooth crown traits, postcanine heritabilities were more often non-significant; however, those traits with significant heritability also tended to produce higher estimates. Genetic correlations were unremarkable, in part, because they were underpowered. However, M1 results may provide insight into the complex relationship between genes, environment, and development in determining ultimate crown form. K E Y W O R D Sbiodistance, dental morphology, heritability, pleiotropy, quantitative genetics

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Impact of genetics on third molar agenesis

Cited by 14 publications

References 31 publications

Third molar agenesis in modern humans with and without agenesis of other teeth

Third molar agenesis in modern humans with and without agenesis of other teeth

Peer Review #2 of "Third molar agenesis in modern humans with and without agenesis of other teeth (v0.2)"

Quantitative genetic analyses of postcanine morphological crown variation

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