Impact of geometrical uncertainties on 3D CRT and IMRT dose distributions for lung cancer treatment

Schwarz, Marco; Geer, Joris van der; Herk, Marcel van; Lebesque, Joos V.; Mijnheer, Ben J.; Damen, E.

doi:10.1016/j.ijrobp.2006.03.035

Cited by 57 publications

(36 citation statements)

References 32 publications

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“…17, 18 Schwarz et al have evaluated the impact of geometrical uncertainties on lung cancer tumors using periodic models for breathing. 19 The information from this study can also be used to evaluate optimization approaches, such as the Multiple Instance Geometry Approximation, 20 that derive more robust treatment plans by taking known or expected motions into account.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Displacement and Reproducibility of the Breast and Nodal Targets Under Active Breathing Control

Moran

Balter

Ben‐David

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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Purpose-The short-term displacement and reproducibility of the breast or chest wall, and the internal mammary (IM), infraclavicular (ICV), and supraclavicular (SCV) nodal regions have been assessed as a function of breath-hold state using an active breathing control (ABC) device for patients receiving loco-regional breast radiation therapy.Methods-Ten patients were CT scanned using an ABC device at breath hold states of end exhale and 20%, 40%, 60%, and 80% of vital capacity (VC). Patients were scanned before treatment and at one-third and two-thirds of the way through treatment. A regional registration was performed for each target using a rigid-body transformation with mutual information as a metric.Results-Between exhale and 40% of VC, the mean displacement was 0.27/0.34, 0.24/0.31, 0.22/0.19, and 0.13/0.19 cm anterior/superior for the breast or chest wall, and IM, ICV, and SCV nodes, respectively. At 80% of VC, the mean displacement from exhale was 0.84/.88, 0.76/.79, 0.70/0.79, and 0.54/0.56 cm anterior/superior for the breast or chest wall, and IM, ICV, and SCV nodes, respectively. The short-term reproducibility (standard deviation) was < 0.3 and ≤0.4 cm for 40% and 80% of VC, respectively. Displacements up to 1.9 cm were seen for individual patients.Conclusions-The short-term reproducibility of target position is ≤0.4 cm using ABC for all structures for all breath hold states. This information can be used to guide treatment planning optimization studies that consider the effect of motion on target and normal tissue doses with and without active breathing control.

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Section: Discussionmentioning

confidence: 99%

Short-Term Displacement and Reproducibility of the Breast and Nodal Targets Under Active Breathing Control

Moran

Balter

Ben‐David

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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“…Certains auteurs ont proposé de partiellement contrevenir au rapport 83 de l'international Commission on Radiation Units and Measurements (ICRU) [49] en omettant les contraintes de dose maximale, c'est-à-dire en acceptant une hété-rogénéité dans le volume cible prévisionnel, pour permettre cette escalade de dose [50]. Pour Lievens et al, la probabilité de complication pulmonaire était inférieure avec la RCMI, même à 74 Gy, par rapport à celle d'une irradiation conformationnelle à 66 Gy [51].…”

Section: Escalade De Doseunclassified

Radiothérapie conformationnelle avec modulation d’intensité dans les carcinomes bronchiques non à petites cellules

Ayadi¹,

Zahra²,

Thariat³

et al. 2014

Cancer/Radiothérapie

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“…However, the improvement of uniformity of target dose could increase the volume of the low dose area in nearby OARs. As a result the volume of low dose area in the lung could be significantly increased 12, 13. Shirvani et al found that the proportion of patients under IMRT treatment increased year by year and V20 of lung decreased significantly in IMRT group based on 3986 patients.…”

Section: Introductionmentioning

confidence: 99%

Reducing dose to the lungs through loosing target dose homogeneity requirement for radiotherapy of non small cell lung cancer

Miao

Yan

Tian

et al. 2017

J Applied Clin Med Phys

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It is important to minimize lung dose during intensity‐modulated radiation therapy (IMRT) of nonsmall cell lung cancer (NSCLC). In this study, an approach was proposed to reduce lung dose by relaxing the constraint of target dose homogeneity during treatment planning of IMRT. Ten NSCLC patients with lung tumor on the right side were selected. The total dose for planning target volume (PTV) was 60 Gy (2 Gy/fraction). For each patient, two IMRT plans with six beams were created in Pinnacle treatment planning system. The dose homogeneity of target was controlled by constraints on the maximum and uniform doses of target volume. One IMRT plan was made with homogeneous target dose (the resulting target dose was within 95%–107% of the prescribed dose), while another IMRT plan was made with inhomogeneous target dose (the resulting target dose was more than 95% of the prescribed dose). During plan optimization, the dose of cord and heart in two types of IMRT plans were kept nearly the same. The doses of lungs, PTV and organs at risk (OARs) between two types of IMRT plans were compared and analyzed quantitatively. For all patients, the lung dose was decreased in the IMRT plans with inhomogeneous target dose. On average, the mean dose, V5, V20, and V30 of lung were reduced by 1.4 Gy, 4.8%, 3.7%, and 1.7%, respectively, and the dose to normal tissue was also reduced. These reductions in DVH values were all statistically significant (P < 0.05). There were no significant differences between the two IMRT plans on V25, V30, V40, V50 and mean dose for heart. The maximum doses of cords in two type IMRT plans were nearly the same. IMRT plans with inhomogeneous target dose could protect lungs better and may be considered as a choice for treating NSCLC.

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Impact of geometrical uncertainties on 3D CRT and IMRT dose distributions for lung cancer treatment

Cited by 57 publications

References 32 publications

Short-Term Displacement and Reproducibility of the Breast and Nodal Targets Under Active Breathing Control

Short-Term Displacement and Reproducibility of the Breast and Nodal Targets Under Active Breathing Control

Radiothérapie conformationnelle avec modulation d’intensité dans les carcinomes bronchiques non à petites cellules

Reducing dose to the lungs through loosing target dose homogeneity requirement for radiotherapy of non small cell lung cancer

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