Impact of glycemic control on advanced glycation and inflammation in overweight and obese patients with type 2 diabetes mellitus

Kalninova, J.; Jakuš, Vladimír; Glejtkova, M.; Kuračka, L; Sandorova, E.

doi:10.4149/bll_2014_089

Cited by 14 publications

(11 citation statements)

References 92 publications

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“…TNF- α and MCP-1 are two proinflammatory cytokines that can be released by adipose tissue. In the current study, the results showed that the visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were significantly lower than those in obesity and T2DM groups ( P < 0.01), which were consistent with the previous study where TNF- α and MCP-1 were elevated in poor glycemic control and good glycemic control overweight and obese patients [ 16 ], suggesting that the immune response of visceral adipose tissue was changed during the occurrence of obesity and T2DM.…”

Section: Discussionsupporting

confidence: 92%

Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population

Zhang

Ding

et al. 2015

Journal of Diabetes Research

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Our results showed that, at the same BMI level, Uygurs have greater WHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic blood pressure, blood glucose, and fructosamine in Uygur male subjects were lower than those in Kazak male subjects. In contrast, systolic blood pressure values in Uygur subjects were greater than those in Kazak subjects, and blood glucose values were greater in Uygur female subjects than in Kazak female subjects. Additionally, in Uygurs, visceral adipose tissue expression levels of TBX1 and TCF21 were greater in obesity group than in normal and T2DM groups and lower in T2DM group than in normal group (P < 0.01). The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were lower than those in obesity and T2DM groups (P < 0.01). In conclusion, T2DM in Uygurs was mainly associated with not only distribution of adipose tissue in body, but also change in metabolic activity and adipocytokines secretion of adipose tissue.

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Section: Discussionsupporting

confidence: 92%

Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population

Zhang

Ding

et al. 2015

Journal of Diabetes Research

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“…In principle, obesity and diabetes have been associated with matrix stiffening that may be at least partially mediated by AGE cross-links. 49,50 Emission from such cross-links is more consistent with the excitation/emission wavelengths of our study, than LOX-mediated cross-links. However, the impact of AGE cross-links on mechanical properties may be highly dependent on the type of tissue and the nature of the cross-links.…”

Section: Conclusion and Discussionsupporting

confidence: 87%

Factors associated with obesity alter matrix remodeling in breast cancer tissues

et al. 2020

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Obesity is associated with a higher risk of developing breast cancer and with worse disease outcomes for women of all ages. The composition, density, and organization of the breast tissue stroma are also known to play an important role in the development and progression of the disease. However, the connections between obesity and stromal remodeling are not well understood. We sought to characterize detailed organization features of the collagen matrix within healthy and cancerous breast tissues acquired from mice exposed to either a normal or high fat (obesity inducing) diet. We performed second-harmonic generation and spectral two-photon excited fluorescence imaging, and we extracted the level of collagen-associated fluorescence (CAF) along with metrics of collagen content, three-dimensional, and two-dimensional organization. There were significant differences in the CAF intensity and overall collagen organization between normal and tumor tissues; however, obesity-enhanced changes in these metrics, especially when three-dimensional organization metrics were considered. Thus, our studies indicate that obesity impacts significantly collagen organization and structure and the related pathways of communication may be important future therapeutic targets. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Diabetes mellitus is a serious global health problem resulting from insulin insuffi ciency or ineffi ciency which, its prevalence is increasing dramatically, and due to the rising rate of obesity and sedentary lifestyle, about 552 million people are estimated to be suffering from diabetes mellitus worldwide by 2030 (1,2). Diabetes-induced hyperglycemia and the corresponding glucotoxicity result in macro and microvascular complications such as diabetic neuropathy, nephropathy, retinopathy, and cardiomyopathy (3).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-146a and its adapter proteins are affected by diabetes in rat’s heart

Eftekhar¹,

Zaboli²,

Katebi³

et al. 2016

BLL

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OBJECTIVES: This study was conducted to explore whether microRNA-146a and its adapter proteins (TNF-α receptor-associated factor 6 (TRAF6) and interleukin-1 receptor-associated kinase 1 (IRAK1)) are affected by diabetes in the rat heart. METHODS: Twelve male Sprague-Dawley rats were randomized into control and diabetic groups (n = 6). Streptozotocin-nicotinamide experimental model was used to induce type 2 diabetes. The gene expression of MicroRNA-146a, nuclear factor-κB (NF-κB), IRAK1 and TRAF6, as well as NF-κB activity, IRAK1 and TRAF6 protein levels were measured. Moreover, NF-κB activity was measured in response to miR-146a mimic transfection (20 nmol) in human umbilical vein endothelial cells (HUVECs) under hyperglycemic condition (25 mM D-glucose for 24 h). RESULTS: The expression of MicroRNA-146a was increased in the heart tissue, 2 months after diabetes induction and in HUVECs. Also, the mRNA and protein levels of NF-κB, IRAK1 and TRAF6 were increased in the heart of diabetic rats. Moreover, transfection of miR-146a mimic prevented from a signifi cant increase of NF-κB activity in hyperglycemic HUVECs. CONCLUSION: Presumably, a defect in the regulation of IRAK1 and TRAF6 can weaken miR-146a regulatory effect and provides a situation for sustained activation of NF-κB and its targets to promote cardiac cells toward abnormalities (Fig. 3, Ref. 28).

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Impact of glycemic control on advanced glycation and inflammation in overweight and obese patients with type 2 diabetes mellitus

Cited by 14 publications

References 92 publications

Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population

Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population

Factors associated with obesity alter matrix remodeling in breast cancer tissues

MicroRNA-146a and its adapter proteins are affected by diabetes in rat’s heart

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