According to current concepts, the construction of multi-storey and high-rise buildings is quite topical. Increasing the number of storeys and building density provokes an increase in loads and forces on the structural elements of the building, as well as on the soil base. It is necessary to take into account the mechanical characteristics of the soils underlying multi-storey buildings to improve the design models of objects when determining the forces and deformations in their elements. A vital indicator in monitoring the structural characteristics of buildings is global stiffness. Natural frequencies determined by modal analysis are used to detect its change. The purpose of this study is a numerical analysis of the effect of changes in the parameters of the soil base on the natural frequencies and values of vibrations of multi-storey reinforced concrete frame buildings using software systems. In this study, four variants of design models with rigidly fixed foundations and elastic foundations with different types of soils were developed.In the models with elastic foundations, stable soils were used, such as sandy, moderately stable, represented by loams and sandy loams, and weak soils containing a layer of peat. The building scheme was developed using the SCAD software package with the application of the finite element method. Taking into account that 90% of the territory of Ukraine is located in complex engineering and geological conditions, the use of the finite element method allows to effectively solve complex problems of interaction of heterogeneous elements, including in a nonlinear approach. As a result, it was found that the type of soil foundation affects the change in the natural vibration frequencies of a building. In the model with a rigidly fixed foundation, the frequencies are the highest, and the eigenvalues of oscillations are the lowest. A point that should be mentioned is that in the variants with an elastic foundation, the lowest frequencies are observed in the model on weak soils, and the highest values are typical for sandy foundation soils.