Limited knowledge and negative attitudes about menopause among postmenopausal women (PMW) create a multitude of health-related issues leading to impaired quality of life (QOL) among them. This study evaluated the impact of a health-promoting lifestyle education intervention (HPLEI) on knowledge, attitude, and QOL in a group of PMW in Sri Lanka. A quasi-experimental study was conducted with 72 PMW, matched for sociodemographic status of the community from two geographically separated areas in Galle, and they were allocated to intervention (n=37) and control (n=35) groups. HPLEI is comprised of health education sessions focused on postmenopausal health management with lifestyle modifications provided only for the intervention group for 8 weeks and follow-up for 6 months. The control group was not given any planned education programme and was allowed to proceed with the usual lifestyle during this period. Knowledge, attitude, menopause-specific QOL (MENQOL), and overall QOL were evaluated in both groups with self-administered questionnaires at the baseline, after 8 weeks of education sessions and at the end of 6 months of follow-up. The mean (SD) ages of the intervention and control groups were 54.6 (4.5) and 56.5 (3.4) (p=0.06) years, respectively. All evaluated variable scores were not different between the intervention and control groups (p>0.05) at the baseline. In the intervention group, knowledge (mean±SD; 21.70±1.05) and attitude (mean±SD; 44.02±5.33) scores increased at the end (p<0.001). In the control group, a marginal increase in all dimensions of knowledge scores (mean±SD; 9.71±2.21) and unchanged attitude scores (mean±SD; 23.91±7.56) were seen. All MENQOL scores decreased during the follow-up in the intervention group (mean±SD; 138.51±18.47) (p<0.001) except the sexual domain (p=0.32). MENQOL scores were increased in the control group (mean±SD; 92.05±28.87) (p<0.001) with time. Overall QOL scores increased (mean±SD; 74.85±9.71) (p<0.001) in the intervention group during the study period and in the control group overall QOL (mean±SD; 51.03±13.61) showed a reduction (p<0.001) at the end. Health education focused on health-promoting lifestyle modifications was effective in improving knowledge, attitude, MENQOL, and overall QOL of PMW.