Impact of Heat Stress on Bovine Sperm Quality and Competence

Capela, L.; Leites, Inês; Romão, R.; Lopes-da-Costa, L.; Pereira, Manuel F. O. Seabra

doi:10.3390/ani12080975

Cited by 28 publications

(22 citation statements)

References 100 publications

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“…Formation of the two sperm cells is the central developmental process occurring at the bicellular stage. Disruption of spermatogenesis in mammals due to HS has been shown to negatively impact male reproduction altering sperm morphology and leading to DNA fragmentation (Hansen, 2009; Garcia-Oliveros et al, 2020; Capela et al, 2022). In plants little is known on the impact of high temperatures for sperm cell formation.…”

Section: Discussionmentioning

confidence: 99%

Heat stress at the bicellular stage inhibits sperm cell development and their transport into pollen tubes

Li,

Bruckmann,

Dresselhaus

et al. 2023

Preprint

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For a successful double fertilization process in flowering plants (angiosperms), pollen tubes each deliver two non-motile sperm cells towards female gametes (egg and central cell, respectively). Heatwaves especially during the reproduction period are threatening male gametophyte (pollen) development, which results in severe yield losses. By using maize as a crop and grass model system, we found strong seed set reduction when moderate heat stress was applied for two days during the uni- and bicellular stages of pollen development. We show that heat stress accelerates pollen development and impairs pollen germination capabilities, when applied at the unicellular stage. Heat stress at the bicellular stage impairs sperm cell development and their transport into pollen tubes. To understand the course of the latter defects, we used marker lines and analyzed the transcriptomes of isolated sperm cells. While heat stress also affects the expression of genes involved in transcription, RNA processing and translation, especially genes in DNA replication and the cell cycle were mis-regulated. This includes centromeric histone CENH3 and alpha-tubulin. Most mis-regulated genes are involved in transition from metaphase to anaphase during pollen mitosis II (PM II). Heat stress activates spindle assembly check point and meta- to anaphase transition genes in sperm cells. In summary, mis-regulation of the identified genes during heat stress at the bicellular stage explains sperm cell development and transport defects ultimately leading to sterility.

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Section: Discussionmentioning

confidence: 99%

Heat stress at the bicellular stage inhibits sperm cell development and their transport into pollen tubes

Li,

Bruckmann,

Dresselhaus

et al. 2023

Preprint

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“…One of the mechanisms responsible for the occurrence of testicular heat stress is the increase in ambient temperature provided by global climate change (140). Given this condition, several studies have reported the negative effects of increased environmental temperatures on male reproduction (141).…”

Section: Consequences Of Increased Testicular Temperature Due To Clim...mentioning

confidence: 99%

Animal welfare and effects of per-female stress on male and cattle reproduction—A review

Silva

Camargo-Júnior

et al. 2023

Front. Vet. Sci.

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Thermal stress causes severe effects on the wellbeing and reproduction of cattle, including changes in oogenesis and spermatogenesis, generating great concerns, which last for decades. In cattle, the occurrence of thermal stress is associated with a reduction in the production of spermatozoids and ovarian follicles, in addition to the increase of major and minor defects in gametes or in their intermediate stages. In bovine females able to reproduce, a reduction in the rate of estrus manifestation and an increase in embryonic mortality has been observed. Therefore, keeping animals on good welfare conditions, with water supply and in shaded areas can favor the improvement of different reproductive parameters. For all this, the present study aimed to gather, synthesize and argue recent studies related to animal welfare, focusing on the effects of thermal stress on the reproduction of cattle, aiming to support possible strategies to mitigate the harmful effects of thermal stress in this species.

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“…Such bulls showed clear evidence that a warm environment can lead to a decrease in sperm morphology and motility [49]. In addition, it is clear that reactive oxygen species generation are involved [50].…”

Section: Is "Heat-stress" Physiologically Relevant?mentioning

confidence: 99%

The Impact of Testicular Hyperthermia, Its Physiological Relevance and the Ability of Antioxidants to Overcome the Condition

Robinson,

Ogle,

Netherton

et al. 2023

Preprint

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Testicular heat stress is a well described phenomenon that occurs in mammals that possess a scrotum. Different models to induce testicular hyperthermia, such as surgical cryptorchidism, hot water bath, scrotal insulation or increased environmental temperature have all shown that spermatocytes and spermatids are unambiguously affected by high temperature, resulting in poor sperm production weeks later. Furthermore, a body of evidence suggest the involvement of oxidative stress is either a major or contributory pathway, which gives rise to the potential to overcome this condition. Whilst experimental models conclusively show the deleterious effect of testicular heat on sperm quality, the physiological relevance of the work is still debated. Herein we summarise a cohort of studies that report the effect of “season” on sperm quality. The data show season can affect sperm production, motility and morphology depending on where the work was performed. In countries where temperatures drop below zero, there is evidence showing summer conditions tend to improve semen quality. However, in sub-tropical countries, some studies show a decrease in summer, whilst others show no change. Herein we offer a reasonable explanation for this apparent controversy and present a range of antioxidant supplements that may offer some protection against testicular hyperthermia.

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Impact of Heat Stress on Bovine Sperm Quality and Competence

Cited by 28 publications

References 100 publications

Heat stress at the bicellular stage inhibits sperm cell development and their transport into pollen tubes

Heat stress at the bicellular stage inhibits sperm cell development and their transport into pollen tubes

Animal welfare and effects of per-female stress on male and cattle reproduction—A review

The Impact of Testicular Hyperthermia, Its Physiological Relevance and the Ability of Antioxidants to Overcome the Condition

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