Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

Kountouras, Jannis; Papaefthymiou, Apostolis; Deretzi, Georgia; Vardaka, Elisabeth; Soteriades, Elpidoforos S.; Tzitiridou‐Chatzopoulou, Maria; Gkolfakis, Paraskevas; Karafyllidou, Kyriaki; Doulberis, Michael

doi:10.3390/microorganisms9112351

Cited by 28 publications

(29 citation statements)

References 191 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies involving H. pylori infection in the rise of blood pressure are numerous [27,[40][41][42][43]. Accordingly, in our study we found a statistically higher prevalence of blood hypertension, confirmed by the antihypertensive treatment, in patients with H. pylori infection, compared with patients without, after adjusting for covariates such as age, smoke, overweight/obesity, hypercholesterolemia, and diabetes, traditionally considered major risk factors for blood hypertension.…”

Section: Discussionsupporting

confidence: 59%

Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-Lasting Helicobacter pylori Gastritis

Dore

Saba

Tomassini

et al. 2022

JCM

View full text Add to dashboard Cite

Helicobacter pylori infection has been reported to be positively associated with hypertension, although with conflicting results. In this study, the relationship between H. pylori infection and hypertension, as well as atherosclerotic carotid lesions, was analyzed. Methods. Clinical records of patients referred to undergo upper endoscopy and gastric biopsy were retrieved. Information regarding the presence of H. pylori infection with atrophy/metaplasia/dysplasia (interpreted as a long-lasting infection), and current or past H. pylori infection was collected, as well as demographic variables, smoking habits, body mass index (BMI), dyslipidemia, diabetes, hypertension, presence of carotid lesions, and current treatment, and analyzed by multivariable regression models. Results. A total of 7152 clinical records from patients older than 30 years (63.4% women) were available for the study. Hypertension was present in 2039 (28.5%) patients and the risk was significantly increased in those with long-lasting H. pylori infection after adjusting for age decades, sex, BMI, cigarette smoking, diabetes, and dyslipidemia (OR 1.17, 95% CI 1.02–1.35). In addition, the long-lasting H. pylori infection was an independent risk for carotid plaques (OR 2.15, 95% CI 1.14–4.09). Conclusions. Our retrospective study demonstrated that long-lasting H. pylori infection is an independent risk factor for hypertension and the presence of carotid lesions after adjusting for potential confounders, although further validation our findings is needed from prospective studies.

show abstract

Section: Discussionsupporting

confidence: 59%

Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-Lasting Helicobacter pylori Gastritis

Dore

Saba

Tomassini

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…Up to now the relationship between H. pylori -induced gastritis and atherosclerosis, and CHD remains unclear. Among other entities, H. pylori has been implicated in the pathogenesis of the metabolic syndrome with an arterial hypertension, which is a risk factor for cardio-cerebrovascular diseases 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Coronary heart disease (CHD) is a chronic disease of the coronary vessels, which is classified as inflammatory disease 1 – 3 . This is because of an increased level of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, upregulation of adhesion molecules: intracellular adhesion molecules (ICAM)-1 and -2, vascular cell adhesion molecule 1 (VCAM-1), platelet endothelial cell adhesion molecule 1, macrophage chemotactic protein-1 (MCP-1), P-,L-,E- selectins, and acute phase proteins including C-reactive protein (CRP), amyloid A, fibrinogen and homocysteine 4 – 9 .…”

Section: Introductionmentioning

confidence: 99%

Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks

Gonciarz

Lechowicz

Urbaniak

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Helicobacter pylori (Hp) Gram-negative bacteria cause gastritis or gastric ulcers. They may be involved in the development of systemic diseases i.e. coronary heart disease (CHD). Both Hp infection and CHD are related to inflammation accompanied by C-reactive protein (CRP), tumor necrosis factor alfa (TNF-α) and homocysteine. Low density lipoprotein (LDL) and triglicerides are a classic risk factors of CHD. Infrared spectroscopy has been introduced for monitoring chronic infections or endogenous disorders using specific absorption bands for biocomponents typed as diagnostic markers. In this study we selected specific motives of infrared radiation (IR) spectra for the sera from CHD patients infected with Hp. In total 141 sera were used: 90 from patients with CHD, all Hp positive, and 51 from healthy donors, 32 Hp negative and 21 Hp positive. Hp status was evaluated by anti-Hp IgG antibodies and/or 13C urea breath testing. IR spectra were measured using FT-IR/FT-NIR Spectrum 400 spectrometer (PerkinElmer) chemometrically analyzed using artificial neural networks and they showed differences in absorption bands corresponding to triglicerides, CRP, homocysteine, LDL and TNF-α, and selected component groups between CHD patients infected with Hp vs healthy uninfected donors (96.15% accuracy). Triglicerides and CRP were the best biomarkers linking Hp infection with CHD.

show abstract

“… 52 In addition, H. pylori trigger many mediators that support hypertension pathogenicities such as fibrinogen, interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), as they are related to insulin resistant which is one of the major causes that leads to hypertension and diabetes mellitus type 2 ( Figure 5 ). 53 , 54 Whether hypertension contributes to H. pylori infection or not is still unclear and needs to be investigated. Some studies claimed that H. pylori eradication improved blood pressure values among hypertension patients, 55 , 56 indicating the importance of routine investigation for H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Acute Helicobacter pylori Infection Prevalence Among Renal Failure Patients and Its Potential Roles with Other Chronic Diseases: A Retrospective Cohort Study

Alhoufie¹,

Ibrahim²,

Alhazmi³

et al. 2022

IDR

View full text Add to dashboard Cite

Background: Helicobacter pylori (H. pylori) infection is relevant to several chronic human diseases, from digestive diseases to renal, metabolic, and cancer diseases. H. pylori infections and chronic kidney diseases are in increasing, global records; if not well controlled in a specific population, these diseases might lead to more clinical complications. Methods: In this retrospective study, we investigated the prevalence of acute H. pylori infections among 127 dialysis patients via subjecting their serums to the enzyme-linked immunosorbent assay (ELISA) to detect the human Immunoglobulin M (IgM) against H. pylori infections. Samples were from dialysis patients in a single hemodialysis center in Medina, Saudi Arabia, from January to August 2021. Results: Our results indicated the significant prevalence of H. pylori acute infections among 33.1% of renal failure patients recruited in this study, chi-squared: 14.559, p-value: 0.0001. In addition, no significant occurrence of acute H. pylori infection among males and females, chi-squared: 1.823, p-value: 0.177. Furthermore, the prevalence of acute H. pylori infection was not significant in different age groups of renal failure patients. Chi-squared: 6.803, p-value: 0.147, despite H. pylori-infected cases predominantly represented in patients above 51 years. Moreover, we noticed that hypertension, followed by diabetes, was the most prevalent underlying medical condition among acute infected H. pylori and renal failure patients. Conclusion:We documented the significant prevalence of acute H. pylori infection among renal failure patients. We also highlighted and discussed the possible potential roles of H. pylori in renal failure and other chronic diseases. Routine screening and treatment for acute H. pylori infection for chronic kidney diseases, hypertension, and diabetes patients would positively reduce the bacterium's progressive effects on them. They might even improve the control of these diseases.

show abstract

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

Cited by 28 publications

References 191 publications

Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-Lasting Helicobacter pylori Gastritis

Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-Lasting Helicobacter pylori Gastritis

Searching for serum biomarkers linking coronary heart disease and Helicobacter pylori infection using infrared spectroscopy and artificial neural networks

Acute Helicobacter pylori Infection Prevalence Among Renal Failure Patients and Its Potential Roles with Other Chronic Diseases: A Retrospective Cohort Study

Contact Info

Product

Resources

About