“Impact of Hemodialysis Frequency and Duration on Changes in Haematological Markers and Electrolytes in Patients with End-Stage Renal Disease: A Prospective, Multi-Center Study”

Abstract

Background: Chronic kidney disease affects 200 million people globally. Global prevalence was 8-16%, rising 7% yearly. India's National Renal Foundation ranks kidney illnesses third among life-threatening diseases. GFR, proteinuria, azotemia, and uremia indicate kidney impairment. Anemia, fluid and electrolyte imbalances and metabolic bone disease resulting from kidney dysfunction.Material and Methods: We conducted a prospective and retrospective observational study on 150 End Stage Renal Disease (ESRD) patients who had been on hemodialysis for at least a year. The impact of dialysis duration on various haematological parameters and electrolytes was observed and interpreted. The change in the percentage mean of each parameter was calculated with respect to duration and frequency.Results: Out of 150 patients maximum were of 41 to 60 years. Prevalence of ESRD was higher in males, also hypertension was major the cause. Levels of haemoglobin, PCV level, RBCs count, s. creatinine, s. urea and electrolytes were statistically significant in the higher duration of dialysis as compared to the lower duration. The majority of patients were observed with moderate anemia. All ESRD patients showed hyperparathyroidism. Conclusion: Higher duration of dialysis was proven better than a lower duration of dialysis. No significant difference was observed with respect to a different frequency.