Impact of Hemodialysis on Serum Zinc and Copper Level in CKD Patients

Balla, Shehab Elzain Hamad; Adam, Ali Ahmed

doi:10.7324/japs.2016.60423

Cited by 4 publications

(12 citation statements)

References 23 publications

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“…10 Some studies showed that blood Cu levels were within a normal range or lower 27 , while in other studies Cu levels were higher. 8,28 Zinc concentrations were in compliance with the international standard during the entire study period and in all the hospitals in the present study. The results for Zn levels disagree with a previous study by Al-Naseri et al which showed Research non-compliance with international standards for the same hospitals.…”

Section: Discussionsupporting

confidence: 63%

“… 10 Some studies showed that blood Cu levels were within a normal range or lower 27 , while in other studies Cu levels were higher. 8 , 28…”

Section: Discussionmentioning

confidence: 99%

“… 7 Copper deficiency can cause anemia and neutropenia. 8 Zinc deficiency causes or contributes to a number of infections and non-specific conditions commonly observed in patients with hemodialysis, including anorexia, dysgeusia, and impeded cognitive function. 9…”

Section: Introductionmentioning

confidence: 99%

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Heavy Metals in Dialysis Fluid and Blood Samples from Hemodialysis Patients in Dialysis Centers in Baghdad, Iraq

Humudat

Al‐Naseri

2020

Journal of Health and Pollution

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Background. The kidney is the first target organ of heavy metal toxicity due to its capacity to reabsorb and accumulate divalent metals. Hemodialysis therapy is used to purify the blood of individuals with impaired kidney function. Objective. The aim of the present study was to evaluate the relationship between dialysis fluid quality and the health of hemodialysis patients. Methods. A field sampling program was conducted to collect blood samples from 320 hemodialysis patients (56% males and 44% females) in order to examine the concentrations of heavy metals that typically occur in municipal water in Baghdad (aluminum (Al), copper (Cu), lead (Pb), and zinc (Zn)), and explore associations with the same metals in dialysis fluid collected from four major dialysis centers in Baghdad hospitals for a period of one year (2018). Results. The results showed that the dialysis fluid quality was not in compliance with international standards. The dialysis fluid in 63% of the samples contained high Al concentrations, while Cu and Zn concentrations were within international standards. Lead concentrations were elevated in dialysis fluid in some hospitals as well. Discussion. The average blood levels of biologically important heavy elements were significantly varied in hemodialysis patients when compared with local reference values. Conclusions. Since both deficiency and excess elements are potentially harmful, the hypothesis that heavy element status affects the risk of adverse clinical outcomes is a worthy investigation. Participant Consent. Obtained Ethics Approval. The study was approved by the Baghdad Ethics Committee of the Iraqi Ministry of Health and Environment. Competing Interests. The authors declare no competing financial interests.

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Section: Discussionsupporting

confidence: 63%

“… 10 Some studies showed that blood Cu levels were within a normal range or lower 27 , while in other studies Cu levels were higher. 8 , 28…”

Section: Discussionmentioning

confidence: 99%

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Heavy Metals in Dialysis Fluid and Blood Samples from Hemodialysis Patients in Dialysis Centers in Baghdad, Iraq

Humudat

Al‐Naseri

2020

Journal of Health and Pollution

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“…Trace elements are natural, essential, homogenous, inorganic substances which are taken with food or drink present in minor amounts in the human body, but also have a unique role in a number of important structures and processes. Determining the status of trace elements is difficult and requires specialized equipment (an Atomic Absorption Spectrophotometer) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the studies conducted to date in CKD have focused on the trace elements Zn, Se, and Cu. Most authors found deficient zinc (Zn) [5][6][7][8] and selenium (Se) [9][10][11][12], and moderate excess of copper (Cu) [7,13,14]. Single messages do not find abnormal TE blood levels, or don't accept the existence of deficiencies and explain lower serum levels of these trace elements due to their abnormal redistribution in the tissues.…”

Section: Introductionmentioning

confidence: 99%

Status and relation to inflammation of some serum trace elements (TE) in hemodialysis (HD) patients

Trendafilov¹,

Georgieva²,

Manolov³

et al. 2018

Nephrol Renal Dis

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Introduction: Abnormal blood levels of various trace elements have not been consistently studied in the end-stage renal disease. The uremic patients treated by chronic dialysis lose one important route of trace elements excretion and are exposed to an artificial environment of the dialysis fluid. The process may lead to depletion of biologically essential substances or its accumulation in the patient. Thus, dialysis patients are at risk for both deficiency and accumulation of trace elements, depending on dietary intake, residual kidney function and removal by dialysis. Aim of the study:The present study was pointed to investigate possible existence of trace elements disturbances in uremic patients undergoing regular hemodialysis (HD) treatment and its relationship to some inflammatory markers.Material and methods: Blood samples of 56 patients on hemodialysis and 30 healthy controls were analysed twice in 3 months follow up period for quantitation of serum zinc, selenium and copper, serum albumins -transporters of the TE in the human body, and C-reactive protein (CRP) and interleukine-6 (Il-6) -two important markers of inflammation. Results:The study revealed that serum zinc and selenium concentrations in HD patients are distinctly decreased compared to that of healthy controls, and serum copper was found slightly abnormally increased. Significant negative correlation was found between Zn/CRP and Zn/Il-6 and positive one -between Cu/CRP and Cu/Il-6. Conclusion:Disturbances of trace elements are primarily the result of renal failure, but they may be further exacerbated by the dialysis procedure. Negative correlations between Zn and some inflammatory markers and positive -between them and Cu, probably suggest some influence of these TE on the inflammatory process in dialysis patients.

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Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica

et al. 2021

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Background: Several environmental studies have reported that low-level exposure to nephrotoxic elements increases the risk of chronic kidney disease (CKD). In developing countries, finite resources can limit epidemiological studies and environmental risk assessment; however, the unique soil profile in Jamaica has raised some concerns for the potential exposure to populations who are of high risk. Method: This study investigated the potential for using trace element profiling in CKD, by analysing blood concentration levels of vanadium, chromium, iron, cobalt, copper, zinc, selenium, strontium (Sr), arsenic, barium, cadmium, mercury, and lead. Trace element analysis was conducted using inductively coupled plasma mass spectrometry. Results: One hundred and fifty-eight individuals were included and were predominantly of African descent (98%) and their ages ranged from 21 to 90 years old. Three main correlation clusters were evident: firstly, vanadium, chromium, copper, silicon, and selenium, with mercury and barium more distantly related; secondly, lead, arsenic, nickel, and Sr; and thirdly, iron and zinc. Cadmium was an outlier. Blood Sr was strongly associated with estimated glomerular filtration rate (r = -0.83; p<0.001) and strong linear progression models (r2=0.96; p<0.001). Algorithmic models placed Sr as the highest-ranking trace element biomarker (area under the curve: 95.6%; p<0.001). Discussion: The decline in kidney function may result in the retention of non-essential trace elements. Strong corresponding trends between kidney function and blood Sr concentration indicate biomarker potential for a trace element with a unique profile in patients with CKD. Other significant relationships may also be unveiled as CKD biomarkers as trace element profiling is explored in the region.

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Impact of Hemodialysis on Serum Zinc and Copper Level in CKD Patients

Cited by 4 publications

References 23 publications

Heavy Metals in Dialysis Fluid and Blood Samples from Hemodialysis Patients in Dialysis Centers in Baghdad, Iraq

Heavy Metals in Dialysis Fluid and Blood Samples from Hemodialysis Patients in Dialysis Centers in Baghdad, Iraq

Status and relation to inflammation of some serum trace elements (TE) in hemodialysis (HD) patients

Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica

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