Impact of Hepatitis B Vaccination in Children Born to HBsAg-Positive Mothers: a 20-year Retrospective Study

Bracciale, Laura; Fabbiani, Massimiliano; Strömberg, Anna; Luzzi, Luca; Bernini, Laura; Zanelli, Giacomo

doi:10.1007/s15010-008-8252-3

Cited by 21 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, a similar observation was made on 100 subjects born to HBsAg positive mothers during 1984-2004, in whom 2% had anti-HBc and there were no carriers, yet only 63.3% of uninfected had anti-HBs 10 mIU/mL, the percentage of protected individuals decreasing with time with significant reduction of anti-HBs GMT after 5 years to reach 10 mIU/mL in about 15 years' time. 45 The situation was even more striking among Micronesians vaccinated at birth in that only 7.3% of uninfected individuals had positive antibody. 46 Thus even among complete vaccinees, vaccine-induced immunity should not be taken for granted from the time of adolescence onwards.…”

Section: Waning Of Anti-hbs Titer With Advancing Agementioning

confidence: 99%

“…47 Nevertheless, disappearance of an anamnestic effect has been shown in many studies. 10,40,41,45,48 One study found that following a booster dose in subjects who received 4 doses of vaccine during infancy, 28.7% had undetectable anti-HBs, while HBsAg-specific IFN-g-or IL-5-secreting peripheral blood mononuclear cells remaining negative in 27.2%, and it was estimated that 10.1% of the total population had lost their vaccine-conferred booster response. 49 .…”

Section: Anamnestic Response In Vaccineesmentioning

confidence: 99%

See 1 more Smart Citation

Immune persistence after hepatitis B vaccination in infancy – Fact or fancy?

Lao

2016

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

The hepatitis B vaccine has been introduced for more than 3 decades. In Hong Kong, excellent vaccine coverage through an efficient public health care system, together with supplemental programmes and easy availability of the vaccine, meant that most young pregnant women, and university students at entrance, should have been protected. Yet significant correlations in the prevalence of HBV infection with age were found in these groups of subjects, increasing from low to high endemicity rates from late teenage to the early twenties. This can only be attributed to vaccine failure, and there is cumulating evidence that several factors are involved, including the failure to respond to a primary series of hepatitis B vaccination in infancy, the waning of antibody titer with age, and loss of anamnestic response in a significant portion of the vaccinees. The duration of protection conferred by hepatitis B vaccination in infancy should be re-examined and remedial measures undertaken if its long term protection is found to be insufficient. Otherwise, the efforts to control HBV infection, especially in high endemicity regions, with universal vaccination in infancy would be rendered futile.

show abstract

Section: Waning Of Anti-hbs Titer With Advancing Agementioning

confidence: 99%

Section: Anamnestic Response In Vaccineesmentioning

confidence: 99%

Immune persistence after hepatitis B vaccination in infancy – Fact or fancy?

Lao

2016

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…However, recent studies have found that chronic HBV infection may occur 15 years after immunization in some areas where endemic infection is prevalent [8]. Less analogous data are known in low endemic countries [1,9].…”

Section: Introductionmentioning

confidence: 99%

Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

et al. 2010

View full text Add to dashboard Cite

show abstract

“…One study showed an anamnestic response to the booster dose administered more than 20 years after the primary vaccination in 95.8% of subjects, suggesting a strong persisting immune memory 19 . Two other studies have reported that protection provided by HBV vaccine persists for at least two decades in the great majority of vaccinated individuals 20,21 .…”

Section: Discussionmentioning

confidence: 96%

Anti-HBs levels among children and adolescents with complete immunization schedule against hepatitis B virus. A cross-sectional study in Blumenau, State of Santa Catarina, Brazil, 2007-2008

Livramento

Córdova

Scaraveli

et al. 2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Vaccination is the main tool for preventing hepatitis B virus (HBV) infection; however, following the completion of the vaccination series, the concentrations of anti-HBs can decline over the years and reach levels less than 10mIU/mL. The persistence of protection in these individuals is still unknown. The present study aimed to determine the anti-HBs antibody levels among children and adolescents who had received a complete vaccination course for hepatitis B. Methods: Antibodies against HBV surface antigen (anti-HBs) were tested in 371 individuals aged 10 to 15 years-old. Results: Volunteers who showed undetectable quantities of anti-HBs accounted for 10.2% of the population studied and 39.9% presented antibody titers of less than 10mIU/mL. Anti-HBs ≥ 10mIU/mL were verified in 49.9%. Conclusions: These results corroborate other studies indicating levels of anti-HBs below 10mIU/mL in vaccinated individuals. Additional studies are required to assess whether this indicates susceptibility to HBV infection and the need and age for booster doses.

show abstract

Impact of Hepatitis B Vaccination in Children Born to HBsAg-Positive Mothers: a 20-year Retrospective Study

Cited by 21 publications

References 18 publications

Immune persistence after hepatitis B vaccination in infancy – Fact or fancy?

Immune persistence after hepatitis B vaccination in infancy – Fact or fancy?

Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

Anti-HBs levels among children and adolescents with complete immunization schedule against hepatitis B virus. A cross-sectional study in Blumenau, State of Santa Catarina, Brazil, 2007-2008

Contact Info

Product

Resources

About