Impact of hesperidin in 100% orange juice on chronic disease biomarkers: A narrative systematic review and gap analysis

Abstract

Hesperidin in orange juice may affect chronic disease biomarkers. This narrative systematic review aimed to determine appropriate recommendations toward the dose and frequency of hesperidin consumption from 100% orange juice and conduct a gap analysis. The Preferred Reporting Items for Systematic Review and Meta-analysis was conducted to identify articles through September 2020, utilizing four databases: Pub-Med Central, Agricola, Embase, and MEDLINE. Twenty articles met the inclusion criteria. Results showed that overall effect sizes from the studies were considerably weak. Although higher frequencies, doses, and concentration of hesperidin in 100% orange juice had an impact on global cognitive function, cardiac, insulin, inflammatory, antioxidant/phenolic, and oxidative stress outcomes compared to lower frequencies, doses, and concentration of hesperidin. A gap analysis demonstrated there was a variability in dose and frequency of OJ and hesperidin, diet, genetics, and evaluation measures, which made the role of hesperidin in 100% OJ on chronic diseases unclear. This review revealed a trend toward improving chronic disease biomarkers following consumption of hesperidin in 100% orange juice. Steps can be taken in future research to improve the consistency of clinical study designs, methodology and outcomes.

The effects of hesperidin supplementation on cardiovascular risk factors in adults: a systematic review and dose–response meta-analysis

“…The current meta-analysis found that hesperidin supplementation significantly reduces serum TG, TC, and LDL levels in adults. A systematic review conducted by Tadros et al in 2021 analyzed the impact that hesperidin in 100% orange juice (hesperidin is one of the components in orange juice and other components may also be involved in its effect) has on chronic disease biomarkers in humans over 18 years of age and found results that were not conclusive about HDL or LDL ( 62 ). In 2019, Pla-Paga et al conducted another systematic review to assess the impact of hesperidin consumption on cardiovascular risk biomarkers in both animal studies and human randomized clinical trials.…”

Orange juice intake and lipid profile: a systematic review and meta-analysis of randomised controlled trials

“…Moreover, it has been postulated that the balanced consumption of fruits and vegetables, as a part of healthy dietary patterns, might lead to favourable alterations in lipid profile ( 3 ) .On the other hand, the global production and consumption of fruit is subpar ( 4 ) . However, orange juice (OJ) remains one of the most frequently consumed fruit juices worldwide ( 5 ) , making it the centre of many investigations with regard to diet-related health issues. Natural OJ contains considerable amounts of vitamin C, folate, potassium, fibre and bioactive flavonoids ( 6 ) , all of which contribute to a healthy diet.…”

Does chronic consumption of orange juice improve cardiovascular risk factors in overweight and obese adults? A systematic review and meta-analysis of randomized controlled trials

“…4 In particular, orange juice (OJ) is nutrient-dense and widely consumed worldwide. 5 Specifically, OJ is a good source of various micronutrients, such as vitamin C, thiamin, potassium, folate and citrus flavonoids including hesperidin and narirutin. 6 Biochemical analyses suggest the potential antioxidant effects of citrus flavonoids.…”