2021
DOI: 10.3389/fphys.2021.689807
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Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

Abstract: Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of ost… Show more

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“…Under 1% O 2 conditions, Zn 2+ inhibits HIF-1α expression, promoting migration and proliferation and delaying the senescence of BMSCs [ 198 ]. Ti scaffolds coated on Mg significantly stimulate the proliferation, adhesion, extracellular matrix mineralization, and ALP activity of MC3T3-E1 cells via the JAK1/STAT1/HIF-1α pathway, as well as improve the proliferation, adhesion, tubular formation, scratch healing and Transwell ability of human umbilical vein endothelial cells (HUVECs) through HIF-1α/VEGF pathway [ 199 , 200 ]. Zn/Mg co-implanted Ti scaffold (Zn/Mg-PIII) upregulates magnesium transporter 1 (MAGT1) in HUVECs, promotes Mg 2+ influx, and activates the HIF-1α/VEGF pathway, inducing angiogenesis.…”
Section: Hif-1α Involvement In the Bone Repair Of Biomaterialsmentioning
confidence: 99%
“…Under 1% O 2 conditions, Zn 2+ inhibits HIF-1α expression, promoting migration and proliferation and delaying the senescence of BMSCs [ 198 ]. Ti scaffolds coated on Mg significantly stimulate the proliferation, adhesion, extracellular matrix mineralization, and ALP activity of MC3T3-E1 cells via the JAK1/STAT1/HIF-1α pathway, as well as improve the proliferation, adhesion, tubular formation, scratch healing and Transwell ability of human umbilical vein endothelial cells (HUVECs) through HIF-1α/VEGF pathway [ 199 , 200 ]. Zn/Mg co-implanted Ti scaffold (Zn/Mg-PIII) upregulates magnesium transporter 1 (MAGT1) in HUVECs, promotes Mg 2+ influx, and activates the HIF-1α/VEGF pathway, inducing angiogenesis.…”
Section: Hif-1α Involvement In the Bone Repair Of Biomaterialsmentioning
confidence: 99%