Impact of high bromide intake in the rat dam on iodine transfer to the sucklings

Pavelka, Stanislav; Babický, A; Lener, Jaroslav; Vobecký, Miloslav

doi:10.1016/s0278-6915(02)00024-8

Cited by 25 publications

(12 citation statements)

References 9 publications

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“…The I concentrations for the kidney were less than for the other two organs, indicating the ameliorating effect of I on the kidney. This observation can be explained by Pavelka et al (2002) as high levels of Br intake influence the I metabolism of the animal by increasing the iodide excretion by the kidneys. Fortunately for a 42-day production period I did alleviate the effect of Br not to the expense of I.…”

Section: Discussionmentioning

confidence: 99%

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Toit

Casey

2012

Livestock Science

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The study pursued the hypothesis that bromine (Br) in drinking water at levels > 0.01 mg Br/L may have detrimental effects on the liver, kidneys and thyroid and the thyroid hormones T 3 and T 4 and that iodine (I) may alleviate the potential hazardous effect of Br. The research was done with mixed Ross broiler chickens over a 42-day post-hatch growth period. The trial design was six treatments, T1: 0 mg Br/L and 0 mg I/L; T2: 1 mg Br/L and 0 mg I/L; T3: 3 mg Br/L and 0 mg I/L; T4: 0 mg Br/L and 0.7 mg I/L; T5: 1 mg Br/L and 0.7 mg I/L; and T6: 3 mg Br/L and 0.7 mg I/L delivered via drinking water and three replicates per treatment with 30 birds per replicate. The effect of Br on T 3 and T 4 levels overall was nonsignificant, but T 3 and T 4 levels decreased between Weeks 4 and 6 with a significant effect at Week 6 on T 3 . Br had an overall effect on the thyroid gland (P = 0.0457), liver (P = 0.0025) and kidney (P = 0.0032), and had accumulated in these three organs. Histopathological assessment showed explicit damage to the livers that received the Br treatments. Iodine (0.07 mg/L) ameliorated the negative effects of high Br (3 mg/L Br) concentration and ingestion.

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Section: Discussionmentioning

confidence: 99%

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Toit

Casey

2012

Livestock Science

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“…In a 4-week toxicity study with rats fed 300, 1200, 4800 or 19200 mg NaBr kg À1 diet, Van Logten and co-workers (1973) observed motor incoordination of the hind legs, depressed grooming, and an increase in relative kidney weight only in the highest-dose group. These phenomena were accompanied by a decrease in serum thyroxine (T 4 ), indicating a typical hypothyroidism induced by bromide (Van Leeuwen et al 1983, Loeber et al 1983, Pavelka et al 2002. No changes in kidney function or morphology were observed, but a remarkable complex of presumably related changes in the endocrine system induced by bromide was reported.…”

Section: Effects Of Organic and Inorganic Bromides On Animalsmentioning

confidence: 99%

“…The most striking effects of bromide on the endocrine system were found on the thyroid gland and the gonads (Loeber et al 1983). Pavelka et al (2002) and Vobecký et al (2003) also studied effects of a high bromide intake in lactating rats on the performance of the dams and on the prosperity of the young. These phenomena were accompanied by a decrease in serum thyroxine (T 4 ), indicating a typical hypothyroidism induced by bromide (Van Leeuwen et al 1983, Loeber et al 1983, Pavelka et al 2002.…”

Section: Effects Of Organic and Inorganic Bromides On Animalsmentioning

confidence: 99%

Bromine

Pavelka¹

2004

Elements and Their Compounds in the Environment

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“…Various manifestations influencing production were reported to occur following the ingestion of Br over different time periods. An elevated dietary intake of bromide by rat dams in lactation was found to cause a very significant decrease in weight gain in the suckling offspring (Pavelka et al, 2002). More trials revealed that only half of these sucklings survived and were in a very poor condition.…”

Section: Introductionmentioning

confidence: 97%

“…This was complemented by stagnation in the extent of the consumption of diet and water as well as a drop in milk production rate during the nursing period (Pavelka, 2003). This suggests that bromide ingested by the dam was transported via the milk to the sucklings (Pavelka et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effect of bromine and iodine in drinking water on production parameters of broilers

Toit

Casey

2011

SA J. An. Sci.

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Levels of bromine (Br) in groundwater that exceeded guideline concentrations of 0.01 mg/L prompted the investigation of the effect Br and iodine (I) in drinking water on the production parameters of broilers. The research was done over a 42-day growth period, post-hatch, in which the trial design was: Control: 0 mg Br/L and 0 mg I/L; 1 mg Br/L and 0 mg I/L; 3 mg Br/L and 0 mg I/L; 0 mg Br/L and 0.7 mg I/L; 1 mg Br/L and 0.7 mg I/L; 3 mg Br/L and 0.7 mg I/L, by 3 replicates with 30 birds/replicate, using mixed Ross broiler chickens. Br and I were administered as NaBr and KI. Mortalities, water and feed intakes were recorded daily and live weight once a week. Average daily gains and feed conversion rations were calculated. Different treatments of Br, irrespective of I, decreased water and feed intake significantly. The interaction of Br and I had no significant effect on intake of water or feed. I had an effective ameliorating effect on Br. Bromine administered at 1 and 3 mg Br/L or at ingestion rates of 1.59 and 4.44 mg Br/day affected production parameters.

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Impact of high bromide intake in the rat dam on iodine transfer to the sucklings

Cited by 25 publications

References 9 publications

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Iodine as an alleviator of bromine toxicity in thyroid, liver and kidney of broiler chickens

Bromine

Effect of bromine and iodine in drinking water on production parameters of broilers

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